Olfaction in Juvenile Nasopharyngeal Angiofibroma: The first study

Mishra, Anupam; Pandey, Pankaj; Mishra, Subhash C.

doi:10.1016/j.amjoto.2019.102298

Cited by 1 publication

(3 citation statements)

References 23 publications

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“…There were no uniform one‐size‐fits‐all therapies for olfactory dysfunction identified in the literature, as there was a diverse range of etiologies for smell loss. Seven studies proposed or utilized a specific treatment, including topical or oral administration of prednisolone after head injury, 19 weight gain for patients with anorexia nervosa, 86 and surgical treatment of the obstructive causes 56,77,79‐81 . With regard to corticosteroid use, 3/5 subjects improved with oral administration, and 1/12 improved with topical administration 19 .…”

Section: Discussionmentioning

confidence: 99%

“…75,76 Obstructive causes of acquired olfactory dysfunction included adenotonsillar hypertrophy, [77][78][79] general nasal obstruction, 80 and juvenile nasopharyngeal angiofibroma (JNA). 81 Several developmental or neuropsychiatric conditions were associated with olfactory dysfunction in children, including an association with early onset psychosis, 82,83 attention-deficit/hyperactivity disorder, 84,85 and anorexia nervosa. 86 The final category of olfactory deficits in children included in this review, were those related to infectious or inflammatory processes.…”

Section: Acquired Etiologiesmentioning

confidence: 99%

“…Seven studies proposed or utilized a specific treatment, including topical or oral administration of prednisolone after head injury, 19 weight gain for patients with anorexia nervosa, 86 and surgical treatment of the obstructive causes. 56,77,[79][80][81] With regard to corticosteroid use, 3/5 subjects improved with oral administration, and 1/12 improved with topical administration. 19 Weight gain as a treatment for anorexia nervosa demonstrated an improvement in odor threshold, and odor discrimination, however, odor identification scores did not improve from baseline.…”

Section: Therapiesmentioning

confidence: 99%

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Olfactory Dysfunction in Children: A Scoping Review

Payandeh

Motamed

Kirubalingam

et al. 2023

Otolaryngol.--head neck surg.

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ObjectiveOlfactory disorders are well‐studied in the adult population, however, there is a paucity of literature characterizing olfactory dysfunction in pediatric patients. The purpose of this scoping review was to identify known causes of olfactory loss in pediatric populations, clarify the extent of use and validity of smell tests, and summarize current therapies for olfactory loss.Data SourcesPubMed, Ovid MEDLINE, and Web of Science.Review MethodsDatabases were systematically searched in September 2020. Two independent reviewers conducted the title and abstract screen, followed by review of full‐texts for inclusion based on preset inclusion and exclusion criteria. Extracted data included study type, age/age‐range of participants, gender, radiological evidence of olfactory dysfunction, types and results of smell tests used, etiology of olfactory loss, and therapies employed for olfactory loss.ResultsA total of 103 articles (n = 1654) were eligible for final data extraction. The University of Pennsylvania Smell Identification Test was used most frequently for smell testing (21% of studies). In total, 45 causes of olfactory dysfunction have been elucidated by this study: 22 congenital and 23 acquired. Few therapies were described, and all were specific to the etiology of olfactory loss.ConclusionOlfactory dysfunction has a wide range of etiologies in the pediatric population, and clinicians should have a diagnostic algorithm for how to identify a cause should they encounter it in practice. If no etiology can be identified, education around safety should be provided to both the patient and their caregivers.

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