Olfaction and Vision Meet in the Retina

Dowling, John E.

doi:10.1016/j.neuron.2013.06.024

Cited by 18 publications

(17 citation statements)

References 14 publications

(17 reference statements)

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“…Studies applying multivariate analysis techniques have also found evidence that the HC contains activation patterns that are sensitive to scene‐related information [Bonnici et al, 2012; Liang et al, 2013; but see Diana et al, 2008]. Overall, these extant data, when viewed alongside the large‐scale analysis of individual‐level data reported here, suggest that the HC should be considered a key region in the putative scene processing network [see also Kornblith et al, 2013; Kreiman et al, 2000]. While these results implicate HC in the online processing of visual scenes—contrary to the perspective that HC activation is primarily driven by internally generated thought [Buckner et al, 2008]—it is not possible in this block design study to determine whether HC response is being driven by perceptual processing or scene maintenance across trials [Zeidman et al, 2015].…”

Section: Discussionmentioning

confidence: 51%

Evidencing a place for the hippocampus within the core scene processing network

Hodgetts

Shine

Lawrence

et al. 2016

Human Brain Mapping

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Functional neuroimaging studies have identified several “core” brain regions that are preferentially activated by scene stimuli, namely posterior parahippocampal gyrus (PHG), retrosplenial cortex (RSC), and transverse occipital sulcus (TOS). The hippocampus (HC), too, is thought to play a key role in scene processing, although no study has yet investigated scene‐sensitivity in the HC relative to these other “core” regions. Here, we characterised the frequency and consistency of individual scene‐preferential responses within these regions by analysing a large dataset (n = 51) in which participants performed a one‐back working memory task for scenes, objects, and scrambled objects. An unbiased approach was adopted by applying independently‐defined anatomical ROIs to individual‐level functional data across different voxel‐wise thresholds and spatial filters. It was found that the majority of subjects had preferential scene clusters in PHG (max = 100% of participants), RSC (max = 76%), and TOS (max = 94%). A comparable number of individuals also possessed significant scene‐related clusters within their individually defined HC ROIs (max = 88%), evidencing a HC contribution to scene processing. While probabilistic overlap maps of individual clusters showed that overlap “peaks” were close to those identified in group‐level analyses (particularly for TOS and HC), inter‐individual consistency varied across regions and statistical thresholds. The inter‐regional and inter‐individual variability revealed by these analyses has implications for how scene‐sensitive cortex is localised and interrogated in functional neuroimaging studies, particularly in medial temporal lobe regions, such as the HC. Hum Brain Mapp 37:3779–3794, 2016. © 2016 Wiley Periodicals, Inc.

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Section: Discussionmentioning

confidence: 51%

Evidencing a place for the hippocampus within the core scene processing network

Hodgetts

Shine

Lawrence

et al. 2016

Human Brain Mapping

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“…Taking a mechanistic approach might provide researchers with a way to quantitatively compare the effects of all predation cues across different sensory systems (visual versus chemical versus mechanical) and, more importantly, could demonstrate how prey integrate the different sensory inputs. A recent study demonstrated that, in zebrafish, axons originating from the olfactory bulb innervate the retina and increase luminance sensitivity, suggesting that the interaction between these two sensory systems might influence reproductive behaviour by increasing sensitivity to visual courtship coloration in potential mates (Dowling, 2013;Esposti et al, 2013). It is not hard to imagine that such interactions between sensory systems would be adaptive upon the detection by prey of visual and chemical cues from predators.…”

Section: Discussionmentioning

confidence: 99%

“…However, there is a surprisingly high variation in the effect of ocean acidification among closely related species , indicating that recognising the GABA A involvement is only the first step towards understanding the complex effect of such stressors on prey risk assessment. There is an abundance of information on the structure and function of the olfactory system (Derby and Sorensen, 2008;Dowling, 2013;Firestein, 2001;Hamdani and Døving, 2003;Li, 2014) and the neuroendocrine system of aquatic organisms (Dennis et al, 2014;Døving and Lastein, 2009;Dufty et al, 2002). In addition, much is known about the way predator odours are processed in terrestrial animals (Hegab and Wei, 2014;Li, 2014).…”

Section: Discussionmentioning

confidence: 99%

Mechanisms underlying the control of responses to predator odours in aquatic prey

Mitchell

Bairos‐Novak

Ferrari

2017

Journal of Experimental Biology

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In aquatic systems, chemical cues are a major source of information through which animals are able to assess the current state of their environment to gain information about local predation risk. Prey use chemicals released by predators (including cues from a predator's diet) and other prey (such as alarm cues and disturbance cues) to mediate a range of behavioural, morphological and life-history antipredator defences. Despite the wealth of knowledge on the ecology of antipredator defences, we know surprisingly little about the physiological mechanisms that control the expression of these defensive traits. Here, we summarise the current literature on the mechanisms known to specifically mediate responses to predator odours, including dietary cues. Interestingly, these studies suggest that independent pathways may control predator-specific responses, highlighting the need for greater focus on predator-derived cues when looking at the mechanistic control of responses. Thus, we urge researchers to tease apart the effects of predator-specific cues (i.e. chemicals representing a predator's identity) from those of dietmediated cues (i.e. chemicals released from a predator's diet), which are known to mediate different ecological endpoints. Finally, we suggest some key areas of research that would greatly benefit from a more mechanistic approach.

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“…For example, glypicans have been shown to play a role in axon guidance [310, 324], and in the formation of excitatory synapses [325, 326]. …”

Section: The Role Of Glypicans In Breast Cancer Progressionmentioning

confidence: 99%

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

Theocharis

Skandalis

Neill

et al. 2015

Biochimica et Biophysica Acta (BBA) - Reviews on Cancer

112

127

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Proteoglycans control numerous normal and pathological processes, among which are morphogenesis, tissue repair, inflammation, vascularization and cancer metastasis. During tumor development and growth, proteoglycan expression is markedly modified in the tumor microenvironment. Altered expression of proteoglycans on tumor and stromal cell membranes affects cancer cell signaling, growth and survival, cell adhesion, migration and angiogenesis. Despite the high complexity and heterogeneity of breast cancer, the rapid evolution in our knowledge that proteoglycans are among the key players in the breast tumor microenvironment suggests their potential as pharmacological targets in this type of cancer. It has been recently suggested that pharmacological treatment may target proteoglycan metabolism, their utilization as targets for immunotherapy or their direct use as therapeutic agents. The diversity inherent in the proteoglycans that will be presented herein provides the potential for multiple layers of regulation of breast tumor behavior. This review summarizes recent developments concerning the biology of selected proteoglycans in breast cancer, and presents potential targeted therapeutic approaches based on their novel key roles in breast cancer.

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Olfaction and Vision Meet in the Retina

Cited by 18 publications

References 14 publications

Evidencing a place for the hippocampus within the core scene processing network

Evidencing a place for the hippocampus within the core scene processing network

Mechanisms underlying the control of responses to predator odours in aquatic prey

Insights into the key roles of proteoglycans in breast cancer biology and translational medicine

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