Oleuropein on lipid and fatty acid composition of rat heart

Ruı́z-Gutı́errez, Valentina; Muriana, Francisco J.G.; Maestro, R.; Graciani, E.

doi:10.1016/0271-5317(95)91651-r

Cited by 23 publications

(10 citation statements)

References 23 publications

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“…The most bioactive OMW phenols are o-diphenols such as hydroxytyrosol, oleuropein and tyrosol [51] since they exert an in vitro protective effect against low-density lipoprotein (LDL) oxidation [15,52] as well as being effective at low concentrations to protect human erythrocytes and DNA against oxidative damages [52]. For instance, several authors have reported studies dealing with rat heart [53,54] and have shown the cardio-protective effect of oleuropein.…”

Section: Bioactivities Of Omw Phenolic Compoundsmentioning

confidence: 99%

Recovery and Removal of Phenolic Compounds from Olive Mill Wastewater

Rahmanian

Jafari

Galanakis³

2013

J Americ Oil Chem Soc

272

110

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Food wastes are today considered as a cheap source of valuable components since the existent technologies allow the recovery of target compounds and their recycling inside the food chain as functional additives in different products. Olive mill wastewater (OMW) is generated from olive oil extraction systems. It has high addedvalue compounds namely phenolics, recalcitrants, pectin, and some important enzymes. It causes a certain amount of toxicity/phytotoxicity because of its phenolic compounds. OMW also has significant impacts when discharged directly into surface waters. Therefore, the treatment of olive mill wastewater is very much needed. Several types of techniques have been investigated for OMW treatment along with recovery and removal of its phenolic compounds. Among these techniques, physical ones are utilized for extraction purposes, while chemical and biological methods are applied in order to diminish organic load. In this review, current status and recent developments in the recovery and removal of phenolic compounds from OMW have been critically examined.

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Section: Bioactivities Of Omw Phenolic Compoundsmentioning

confidence: 99%

Recovery and Removal of Phenolic Compounds from Olive Mill Wastewater

Rahmanian

Jafari

Galanakis³

2013

J Americ Oil Chem Soc

272

110

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“…87 Oleuropein increased the level of cholesteryl esters and decreased the level of triacylglycerols and linoleic acid in the heart of test animals. Once incorporated into the heart muscle, it may act as a substitute for the natural antioxidants in the heart 88. It was also able to lower blood pressure and increase blood flow in the coronary arteries in an animal model, relieve arrhythmias and prevent intestinal muscle spasms 89.…”

Section: Biological Effectsmentioning

confidence: 99%

Oleuropein and related compounds

Soler‐Rivas¹,

Espı́n²,

Wichers³

2000

J. Sci. Food Agric.

364

234

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In this paper, oleuropein and some other related phenolic compounds are reviewed. Their occurrence, distribution, biosynthesis and transformation during maturation and during industrial processing (preparation of table olives and oil production) are described. Their role in human health is proposed based on current human, animal and in vitro studies as molecules with antioxidant and antimicrobial properties. © 2000 Society of Chemical Industry

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“…The three extracts were them combined and the solvent evaporated to dryness in a flash evapora tor (40 °C). Caffeic acid and tyrosol were purchased from Fluka (Buchs, Switzerland); Oleuropein was extracted from the leaves of Olea europea (Ruiz-Gutierrez et al, 1995). Hydroxytyrosol was prepared by acidic hydrolysis of oleuropein, (Graciani and Vazquez, 1980).…”

Section: Test Compounds and Chemicalsmentioning

confidence: 99%

Effect of Minor Components of Virgin Olive Oil on Topical Antiinflammatory Assays

Puerta

Martı́nez-Domı́nguez

Ruı́z-Gutı́errez

2000

Zeitschrift Für Naturforschung C

Self Cite

101

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Interest in the health-promoting effects of virgin olive oil, an important part of the "Medi terranean diet", prompted us to determine the antiinflammatory effects of erythrodiol, ßsitosterol and squalene, identified as major components of the so-called "unsaponifiable frac tion" of virgin olive oil, as well as of the phenolic compounds from the "polar fraction": oleuropein, tyrosol, hydroxytyrosol and caffeic acid. Their activities were compared to those of both, total unsaponifiable and polar fractions. This study was designed to analyse the antiinflammatory effect of these specific compounds from virgin olive oil on edema in mice induced by either arachidonic acid (A A ) or 12-O-tetradecanoylphorbol acetate (TPA). The inhibition of the myeloperoxidase (MPO), marker enzyme of the accumulation of neutrophils in the inflamed tissue, was also investigated by the TPA model. The topical application of the olive oil compounds (0.5 mg/ear) produced a variable degree of antiinflammatory effect with both assays. In the auricular edema induced by TPA, ß-sitosterol and erythrodiol from the unsaponifiable fraction of the oil showed a potent antiedematous effect with a 61.4% and 82.1% of inhibition respectively, values not very different to that of the reference indomethacin (85.6%) at 0.5 mg/ear. The four phenolics exerted a similar range of inhibition (33-45%). All compounds strongly inhibited the enzyme myeloperoxidase, indicating a reduction of the neutrophil influx in the inflamed tissues.The strongest inhibitor of A A edema was the total unsaponifiable fraction which inhibition was 34%, similar to that obtained by the reference drug dexamethasone at 0.05 mg/ear. Among the phenolics, oleuropein also produced an inhibition of about 30% with the same dose, but all the other components were found less active in this assay. The anti-inflammatory effects exerted by both unsaponifiable and polar compounds might contribute to the poten tial biological properties reported for virgin olive oil against different pathological processess.

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Oleuropein on lipid and fatty acid composition of rat heart

Cited by 23 publications

References 23 publications

Recovery and Removal of Phenolic Compounds from Olive Mill Wastewater

Recovery and Removal of Phenolic Compounds from Olive Mill Wastewater

Oleuropein and related compounds

Effect of Minor Components of Virgin Olive Oil on Topical Antiinflammatory Assays

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