Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

Sun, Wenyan; Wang, Xin; Hou, Chen; Yang, Liang; Li, Hong-Bao; Guo, Jing; Huo, Chan-Juan; Wang, Molin; Miao, Yu-Wang; Liu, Jiankang; Kang, Yu-Ming

doi:10.1016/j.neuropharm.2016.11.010

Cited by 80 publications

(67 citation statements)

References 37 publications

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“…In addition, HT improved mitochondrial function and induced phase II antioxidative enzymes, which decreased oxidative stress in the brain of db/db mice [144]. Recently, it has also been shown that OLE improves mitochondrial performance through activation of the Nrf2-mediated signaling pathway protecting the hypothalamus from oxidative stress [145]. In conclusion, HT is being considered with interest for possible use in pharmacological mitigation of neurodegenerative processes as a potent antioxidant and a novel small molecule that can upregulate the Nrf2-ARE pathway.…”

Section: Redox Homeostasis and The Inflammatory Responsementioning

confidence: 89%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

311

213

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The increasing extension in life expectancy of human beings in developed countries is accompanied by a progressively greater rate of degenerative diseases associated with lifestyle and aging, most of which are still waiting for effective, not merely symptomatic, therapies. Accordingly, at present, the recommendations aimed at reducing the prevalence of these conditions in the population are limited to a safer lifestyle including physical/mental exercise, a reduced caloric intake, and a proper diet in a convivial environment. The claimed health benefits of the Mediterranean and Asian diets have been confirmed in many clinical trials and epidemiological surveys. These diets are characterized by several features, including low meat consumption, the intake of oils instead of fats as lipid sources, moderate amounts of red wine, and significant amounts of fresh fruit and vegetables. In particular, the latter have attracted popular and scientific attention for their content, though in reduced amounts, of a number of molecules increasingly investigated for their healthy properties. Among the latter, plant polyphenols have raised remarkable interest in the scientific community; in fact, several clinical trials have confirmed that many health benefits of the Mediterranean/Asian diets can be traced back to the presence of significant amounts of these molecules, even though, in some cases, contradictory results have been reported, which highlights the need for further investigation. In light of the results of these trials, recent research has sought to provide information on the biochemical, molecular, epigenetic, and cell biology modifications by plant polyphenols in cell, organismal, animal, and human models of cancer, metabolic, and neurodegenerative pathologies, notably Alzheimer’s and Parkinson disease. The findings reported in the last decade are starting to help to decipher the complex relations between plant polyphenols and cell homeostatic systems including metabolic and redox equilibrium, proteostasis, and the inflammatory response, establishing an increasingly solid molecular basis for the healthy effects of these molecules. Taken together, the data currently available, though still incomplete, are providing a rationale for the possible use of natural polyphenols, or their molecular scaffolds, as nutraceuticals to contrast aging and to combat many associated pathologies.

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Section: Redox Homeostasis and The Inflammatory Responsementioning

confidence: 89%

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Leri

Scuto

Ontario

et al. 2020

IJMS

311

213

View full text Add to dashboard Cite

show abstract

“…In the same model, HT (10-50 mg/kg/day) was also capable to efficiently elevate liver and muscle GST activity, which was reduced by HFD [57]. In addition, eight-week administration of 60 mg/kg/day of oleuropein considerably lowered pro-inflammatory cytokines and blood pressure and increased the levels of Nrf-2 dependent phase II enzymes, such as HO-1 and NQO-1, in spontaneously hypertensive rats (SHR) in comparison with the saline-treated SHR rats [58]. In mice treated with lipopolysaccharide (LPS) to induce acute lung damage, improvement of HO-1 expression related to Nrf-2 activation was instead observed in mice treated orally with Tyr (240 mg/kg) [59].…”

Section: Modulation Of Nrf-2 and Antioxidants Enzymes By Evoo Polyphementioning

confidence: 99%

Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging

Serreli

Deiana

2020

Cells

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The olive-oil-centered Mediterranean diet has been associated with extended life expectancy and a reduction in the risk of age-related degenerative diseases. Extra virgin olive oil (EVOO) itself has been proposed to promote a “successful aging”, being able to virtually modulate all the features of the aging process, because of its great monounsaturated fatty acids content and its minor bioactive compounds, the polyphenols above all. Polyphenols are mostly antioxidant and anti-inflammatory compounds, able to modulate abnormal cellular signaling induced by pro-inflammatory stimuli and oxidative stress, as that related to NF-E2-related factor 2 (Nrf-2) and nuclear factor kappa-light-chain-enhancer of activated B cells (NF-κB), which have been identified as important modulators of age-related disorders and aging itself. This review summarizes existing literature about the interaction between EVOO polyphenols and NF-κB and Nrf-2 signaling pathways. Reported studies show the ability of EVOO phenolics, mainly hydroxytyrosol and tyrosol, to activate Nrf-2 signaling, inducing a cellular defense response and to prevent NF-κB activation, thus suppressing the induction of a pro-inflammatory phenotype. Literature data, although not exhaustive, indicate as a whole that EVOO polyphenols may significantly help to modulate the aging process, so tightly connected to oxidative stress and chronic inflammation.

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“…103 There is also evidence for the stimulatory effect of OL on the expression of the intracellular antioxidant enzymes in free endothelial progenitor cells, via the activation of Nrf2, 104 and in normal human liver cells. 105 In vivo data confirm the ability of OL to increase the level and activities of enzymatic antioxidants in rats fed a cholesterol rich diet, 106 in acute arsenic exposed rats, 107 in the hypothalamus of hypertensive rats, 108 and in the substantia nigra of aged rats 109 and to enhance the level of non-enzymatic antioxidants such as glutathione, α-tocopherol, ascorbic acid and β-carotene in alloxan-diabetic rabbits. 110…”

Section: Antioxidant Effectmentioning

confidence: 65%

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

2018

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Dietary habits have been strongly linked to the maintenance of intestinal epithelium homeostasis, whose alteration may contribute to the pathogenesis of inflammatory diseases and cancer. Polyphenols are among those dietary components suggested to be beneficial for gut health. Within a balanced Mediterranean type diet, a good portion of ingested polyphenols comes from olives and extra virgin olive oil (EVOO). Most of them reach the intestine, where they may be directly absorbed or metabolized under absorption. Others undergo an extensive gastrointestinal biotransformation, producing various metabolites that retain the potential beneficial effect of the parent compounds, or exert a more efficient biological action themselves. Ingested EVOO polyphenols (EVOOP) and their metabolites will be particularly concentrated in the intestinal lumen, where they might exert a significant local action. In this review we summarize the few studies that investigated the effect of EVOOP at the intestinal level, focusing on the possible mechanism of action in relation to their interaction with the microbiota, and their ability to potentially modulate the oxidative status of the intestinal epithelial layer, inflammation and immune response.

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Oleuropein improves mitochondrial function to attenuate oxidative stress by activating the Nrf2 pathway in the hypothalamic paraventricular nucleus of spontaneously hypertensive rats

Cited by 80 publications

References 37 publications

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Healthy Effects of Plant Polyphenols: Molecular Mechanisms

Extra Virgin Olive Oil Polyphenols: Modulation of Cellular Pathways Related to Oxidant Species and Inflammation in Aging

Modulation of intestinal epithelium homeostasis by extra virgin olive oil phenolic compounds

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