Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway

Parzonko, Andrzej; Czerwińska, Monika E.; Kiss, Anna K.; Naruszewicz, Marek

doi:10.1016/j.phymed.2013.05.002

Cited by 86 publications

(56 citation statements)

References 26 publications

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“…According to the above information, it appears oleuropein increased the rate of coronary outflow through the protection of vascular endothelial cells against ischemic-reperfusion injury and attenuation of the no-reflow phenomenon. Parzonko and co-workers in 2013 reported that oleuropein protected the endothelial progenitor cells against angiotensin II cytotoxicity in vitro [46] that is in agreement with the data of our study. Two studies using human settings shown that olive leaf extract enriched with oleuropein had antihypertensive effect that was comparable with captopril as a standard synthetic antihypertensive drug [22], [47].…”

Section: Discussionsupporting

confidence: 93%

Effect of oleuropein on myocardial dysfunction and oxidative stress induced by ischemic-reperfusion injury in isolated rat heart

Esmailidehaj

Bajoovand

Rezvani

et al. 2016

Journal of Ayurveda and Integrative Medicine

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BackgroundStudies have reported antioxidant effect of oleuropein in isolated rat heart.ObjectiveThis study was conducted to investigate whether perfusion of isolated rat heart with oleuropein, before induction of ischemia or at the onset of reperfusion, had any effect on the hemodynamic parameters, infarct size and biochemical factors following ischemic – reperfusion injury.Materials and methodsForty-eight male Wistar rats were divided into 6 groups: the control groups (Con-P and Con-T groups), O10-P and O50-P groups perfused with 10 and 50 μg/g heart oleuropein 5 min before the induction of ischemia and O10-T and O50-T groups perfused with 10 and 50 μg/g heart oleuropein at the beginning of the reperfusion, respectively. All hearts were subjected to 30 min global ischemia and 90 min reperfusion. Hemodynamic parameters were monitored throughout the experiment. The creatine kinase (CK) and malondialdehyde (MDA) level of coronary outflow were assayed and the infarct size measured at the end of reperfusion.ResultsWe found hemodynamic parameters namely heart rate, left ventricular end diastolic pressure (LVEDP), left ventricular developed pressure (LVDP), ±dp/dt and coronary outflow significantly improved in all groups that received oleuropein compared to the control groups. Also, the infarct size was smaller and the coronary outflow levels of CK and MDA were lower in the oleuropein groups compared to the control groups.ConclusionsThe findings suggest that perfusion of isolated rat heart with oleuropein would lead to improved myocardial dysfunction following ischemic-reperfusion injury. Our findings confirm the antioxidant potential of oleuropein.

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Section: Discussionsupporting

confidence: 93%

Effect of oleuropein on myocardial dysfunction and oxidative stress induced by ischemic-reperfusion injury in isolated rat heart

Esmailidehaj

Bajoovand

Rezvani

et al. 2016

Journal of Ayurveda and Integrative Medicine

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“…Oleuropein can also target steps in cancer progression (Abe et al, 2011). Nowadays, oleuropein has garnered interest due to its ability to inhibit proliferation, metastasis and promote apoptosis in several tumor cell lines (Hassan et al, 2012;Zare et al, 2012;Elamin et al, 2013;Kostomoiri et al, 2013;Oi-Kano et al, 2013;Parzonko et al, 2013). In our previous study, oleuropein showed cytotoxic effect on the luminal MCF-7 cells via the induction of the mitochondrial apoptotic pathway (Elamin et al, 2013).…”

Section: Discussionmentioning

confidence: 97%

Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

Hassan¹,

Elamin²,

Omer³

et al. 2013

Asian Pacific Journal of Cancer Prevention

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“…p62 inactivates Keap1 , increasing Nrf2 in the nucleus and consequently increasing the expression of oxidation defense enzyme genes [98]. Oleuropein in a human in vitro model has also been shown to activate Nrf2 and HO-1 expression [99]. However, in vivo human trials with HT have failed to find an up-regulation of phase 2 enzymes which are the by-product of EpRE and Nrf2 stimulation [95].…”

Section: Ole and Evidence Of The Ability Of Olive Leaf Polyphenolsmentioning

confidence: 99%

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

et al. 2016

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The traditional Mediterranean diet (MD) is associated with long life and lower prevalence of cardiovascular disease and cancers. The main components of this diet include high intake of fruit, vegetables, red wine, extra virgin olive oil (EVOO) and fish, low intake of dairy and red meat. Olive oil has gained support as a key effector of health benefits and there is evidence that this relates to the polyphenol content. Olive leaf extract (OLE) contains a higher quantity and variety of polyphenols than those found in EVOO. There are also important structural differences between polyphenols from olive leaf and those from olive fruit that may improve the capacity of OLE to enhance health outcomes. Olive polyphenols have been claimed to play an important protective role in cancer and other inflammation-related diseases. Both inflammatory and cancer cell models have shown that olive leaf polyphenols are anti-inflammatory and protect against DNA damage initiated by free radicals. The various bioactive properties of olive leaf polyphenols are a plausible explanation for the inhibition of progression and development of cancers. The pathways and signaling cascades manipulated include the NF-κB inflammatory response and the oxidative stress response, but the effects of these bioactive components may also result from their action as a phytoestrogen. Due to the similar structure of the olive polyphenols to oestrogens, these have been hypothesized to interact with oestrogen receptors, thereby reducing the prevalence and progression of hormone related cancers. Evidence for the protective effect of olive polyphenols for cancer in humans remains anecdotal and clinical trials are required to substantiate these claims idea. This review aims to amalgamate the current literature regarding bioavailability and mechanisms involved in the potential anti-cancer action of olive leaf polyphenols.

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Oleuropein and oleacein may restore biological functions of endothelial progenitor cells impaired by angiotensin II via activation of Nrf2/heme oxygenase-1 pathway

Cited by 86 publications

References 26 publications

Effect of oleuropein on myocardial dysfunction and oxidative stress induced by ischemic-reperfusion injury in isolated rat heart

Effect of oleuropein on myocardial dysfunction and oxidative stress induced by ischemic-reperfusion injury in isolated rat heart

Oleuropein Induces Apoptosis Via the p53 Pathway in Breast Cancer Cells

Evidence to Support the Anti-Cancer Effect of Olive Leaf Extract and Future Directions

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