Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity

Lago-Sampedro, Ana; Ho-Plágaro, Ailec; García‐Serrano, Sara; Santiago‐Fernández, Concepción; Rodríguez‐Díaz, Cristina; Lopez‐Gómez, Carlos; Martín‐Reyes, Flores; Ruiz-Aldea, Gonzalo; Alcaín‐Martínez, Guillermo; Gonzalo, Montserrat; Montiel-Casado, Custodia; Fernández, José R.; Garcı́a-Fuentes, Eduardo; Rodríguez‐Pacheco, Francisca

doi:10.1016/j.clnu.2021.01.015

Cited by 6 publications

(5 citation statements)

References 55 publications

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“…We also confirmed that the genes PER2, CRY1, BMAL1, etc., were rhythmically expressed in the hypothalamus in the light/dark cycle of 24 h. It is worth noting that CRY1 and PER3 were expected to have a similar transcriptional pattern in SCN, but an opposite expression trend was found in the present study. The similar results have been found in chicken-related reports [6,29], but the expected results were detected in human and mice studies [30,31]. So, the difference of central circadian system of chickens and mammals could be the major cause for this issue.…”

Section: Discussionsupporting

confidence: 87%

Novel Insights into the Circadian Rhythms Based on Long Noncoding and Circular RNA Profiling

Tan,

Zhang,

Dong

et al. 2024

IJMS

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Circadian rhythm disorders pose major risks to human health and animal production activity, and the hypothalamus is the center of circadian rhythm regulation. However, the epigenetic regulation of circadian rhythm based on farm animal models has been poorly investigated. We collected chicken hypothalamus samples at seven time points in one light/dark cycle and performed long noncoding RNA (lncRNA), circular RNA (circRNA), and mRNA sequencing to detect biomarkers associated with circadian rhythm. We enhanced the comprehensive expression profiling of ncRNAs and mRNAs in the hypothalamus and found two gene sets (circadian rhythm and retinal metabolism) associated with the light/dark cycle. Noncoding RNA networks with circadian expression patterns were identified by differential expression and circadian analysis was provided that included 38 lncRNAs, 15 circRNAs, and 200 candidate genes. Three lncRNAs (ENSGALT00000098661, ENSGALT00000100816, and MSTRG.16980.1) and one circRNA (novel_circ_010168) in the ncRNA–mRNA regulatory network were identified as key molecules influencing circadian rhythm by regulating AOX1 in retinal metabolism. These ncRNAs were predicted to be related to pernicious anemia, gonadal, eye disease and other disorders in humans. Together, the findings of this study provide insights into the epigenetic mechanisms of circadian rhythm and reveal AOX1 as a promising target of circadian rhythm regulation.

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Section: Discussionsupporting

confidence: 87%

Novel Insights into the Circadian Rhythms Based on Long Noncoding and Circular RNA Profiling

Tan,

Zhang,

Dong

et al. 2024

IJMS

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“…Other studies revealed that feeding, sleep patterns and clock oscillations in the hypothalamus and peripheral tissues were more strongly affected by meals with a high PA/OA ratio than by those with a low PA/OA ratio (12)(13)(14)(15)(16) . In experiments with human hepatocytes, PA, a SFA, inactivated PPARα (17) and disrupted clock gene expression (18) , while OA, a MUFA, reduced lipotoxicity caused by SFA (19) . In a clinical trial, a switch from a high-carbohydrate, low-fat diet to a low-carbohydrate, high-fat isoenergetic diet affected the diurnal oscillations of core clock genes (PER1, PER2, PER3 and Thyrotroph embryonic factor) and inflammatory genes in human leukocytes (20) .…”

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confidence: 99%

Dietary palmitic acid to oleic acid ratio modulates energy metabolism and biological rhythms in young healthy Japanese males

et al. 2023

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The present study investigated the potential role of the composition of dietary fatty acids in the regulation of biological rhythms, such as the sleep architecture, core body temperature, and leukocyte clock gene expression, in subjects fed meals rich in palmitic acid or oleic acid. Eleven males participated in two sessions of indirect calorimetry in a whole-room metabolic chamber. In each session, subjects consumed three meals rich in palmitic acid (44.3% of total fat as palmitic acid and 42.3% as oleic acid) or oleic acid (11.7% of total fat as palmitic acid and 59.3% as oleic acid) in the metabolic chamber. The ratio of palmitic acid to oleic acid in plasma was significantly lower and fat oxidation was significantly higher during 24 h of indirect calorimetry in the session with meals rich in oleic acid than in that with meals rich in palmitic acid. The duration of slow wave sleep (SWS) was shorter, the latency of SWS was longer, and the nadir of core body temperature after bedtime was later in the session with meals rich in palmitic acid than in that with meals rich in oleic acid. The peak in CRY1 gene expression was earlier and its amplitude was higher in the session with meals rich in palmitic acid than in that with meals rich in oleic acid. In healthy young males, meals rich in palmitic acid decreased fat oxidation and disrupted biological rhythms, particularly the sleep architecture and core body temperature during sleep, more than meals rich in oleic acid.

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“…Thus, the type of fat in conjunction with the total fat intake may have such implications on how dietary fats interact with circadian rhythms governing lipid metabolism at a given intake timing. Since monounsaturated fatty acids (MUFAs) such as oleic acid have also been shown in human explant samples to exhibit circadian restorative abilities, [ 67 ] in addition to the numerous evidence of the benefits of olive oil consumption, it will be of interest to explore whether a high‐fat meal rich in MUFAs taken in the morning or in the evening would produce greater improvements in glycemic, lipidemic, and cardiometabolic health management in humans.…”

Section: Dietary Components Intake Timing and Their Interaction With ...mentioning

confidence: 99%

“…[ 71 ] Similarly for MUFAs, oleic acid was capable of restoring the rhythmicity of clock genes in stomach and jejunal explants obtained from individuals with morbid obesity. [ 67 ] This was effectuated by activating, phase‐shifting, and markedly increasing the amplitude of these genes, thereby improving the robustness of circadian rhythms, which could also potentially improve appetite regulation and glucose homeostasis.…”

Section: Dietary Components Intake Timing and Their Interaction With ...mentioning

confidence: 99%

Is There a Utility of Chrono‐Specific Diets in Improving Cardiometabolic Health?

Yong

Henry

Haldar

2022

Molecular Nutrition Food Res

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Modern lifestyle is generally associated with the consumption of three main meals per day, one of which is typically in the evening or at night. It is also well established that consumption of meals in the later part of the day, notably in the evenings, is associated with circadian desynchrony, which in turn increases the risk of non-communicable diseases, particularly cardiometabolic diseases. While it is not feasible to avoid food consumption during the evenings altogether, there is an opportunity to provide chrono-specific, diet-based solutions to mitigate some of these risks. To date, there has been substantial progress in the understanding of chrononutrition, with evidence derived mainly from in vitro and in vivo animal studies. Some of these approaches include the manipulation of the quality and quantity of certain nutrients to be consumed at specific times of the day, as well as incorporating certain dietary components (macronutrients, micronutrients, or non-nutrient bioactives, including polyphenols) with the ability to modulate circadian rhythmicity. However, robust human studies are generally lacking. In this review, the study has consolidated and critically appraised the current evidence base, with an aim to translate these findings to improve cardiometabolic health and provides recommendations to move this field forward.

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Oleic acid restores the rhythmicity of the disrupted circadian rhythm found in gastrointestinal explants from patients with morbid obesity

Cited by 6 publications

References 55 publications

Novel Insights into the Circadian Rhythms Based on Long Noncoding and Circular RNA Profiling

Novel Insights into the Circadian Rhythms Based on Long Noncoding and Circular RNA Profiling

Dietary palmitic acid to oleic acid ratio modulates energy metabolism and biological rhythms in young healthy Japanese males

Is There a Utility of Chrono‐Specific Diets in Improving Cardiometabolic Health?

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