Oleic Acid Protects Against Oxidative Stress Exacerbated by Cytarabine and Doxorubicin in Rat Brain

Guzmán, David Calderón; Brizuela, Norma Osnaya; Herrera, Maribel Ortíz; Olguı́n, Hugo Juárez; García, Ernestina Hernández; Peraza, Armando Valenzuela; Mejía, Gerardo Barragán

doi:10.2174/1871520615666160504093652

Cited by 24 publications

(12 citation statements)

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“…Similarly, 9-octadecenoic acid resists doxorubicin and cytarabine-induced oxidative stress. Oleic acid (RT), as reported in our present findings (RT 20.46) compound had more favorable effects similar effects on non-HDL-cholesterol concentrations and fasting LDL-cholesterol in comparison to hexadecenoic acid [ 40 ].…”

Section: Resultssupporting

confidence: 54%

Preparation of Novel Nanoformulation to Enhance Efficacy in the Treatment of Cardiovascular Disease

et al. 2022

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Despite many efforts over the last few decades, cardiac-based drug delivery systems are experiencing major problems, such as the effective delivery of the precise amount of a drug. In the current study, an effort has been made to prepare a nano-herbformulation (NHF) to overcome the major problem of conventional intervention. Copper oxide-based NHF was prepared using plant extract of Alternanthera sessilis and characterized using physicochemical techniques such as Transmission electron microscopy (TEM), X-ray powder diffraction (XRD), Dynamic light scattering (DLS), UV-Vis spectroscopy, and Fourier-transform infrared spectroscopy (FTIR). TEM analysis revealed that spherical NHF obtained of size 20–50 nm. In addition, XRD and FTIR confirmed the presence of phytochemicals with biological properties over the surface of copper oxide-based NHF. It was demonstrated that dose-dependent antiapoptotic activity was shown against DOX-induced cardiomyocytes, where ROS levels were significantly reduced to 0.29% from 37.99%. The results of the flow cytometry analysis using PI and Annexin staining further confirmed the antiapoptotic activity of NHF against DOX-induced cardiomyocytes by ROS scavenging. Thus, NHF might be used for cardiovascular disease treatment.

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Section: Resultssupporting

confidence: 54%

Preparation of Novel Nanoformulation to Enhance Efficacy in the Treatment of Cardiovascular Disease

et al. 2022

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“…In addition to palmitoleic acid, C18:1 (oleic acid), C20:1, and C24:1 are other MUFA species that increase in CM plasma. C18:1 is a neurotrophic factor (Velasco et al, 2003) that promotes brain development and neuronal growth (Polo-Hernandez et al, 2014), protects against oxidative stress (Guzman et al, 2016), and reversibly opens the blood-brain barrier (BBB) in rodents (Sztriha and Betz, 1991;Han et al, 2013). In addition, C20:1 and C24:1 are the primary components of sphingolipids involved in myelination.…”

Section: Monounsaturated Fatty Acid Changes In CMmentioning

confidence: 99%

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Castor

Dawlaty

Arakaki

et al. 2021

Front. Mol. Neurosci.

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BackgroundLipids are a primary storage form of energy and the source of inflammatory and pain signaling molecules, yet knowledge of their importance in chronic migraine (CM) pathology is incomplete. We aim to determine if plasma and cerebrospinal fluid (CSF) lipid metabolism are associated with CM pathology.MethodsWe obtained plasma and CSF from healthy controls (CT, n = 10) or CM subjects (n = 15) diagnosed using the International Headache Society criteria. We measured unesterified fatty acid (UFA) and esterified fatty acids (EFAs) using gas chromatography-mass spectrometry. Glycerophospholipids (GP) and sphingolipid (SP) levels were determined using LC-MS/MS, and phospholipase A2 (PLA2) activity was determined using fluorescent substrates.ResultsUnesterified fatty acid levels were significantly higher in CM plasma but not in CSF. Unesterified levels of five saturated fatty acids (SAFAs), eight monounsaturated fatty acids (MUFAs), five ω-3 polyunsaturated fatty acids (PUFAs), and five ω-6 PUFAs are higher in CM plasma. Esterified levels of three SAFAs, eight MUFAs, five ω-3 PUFAs, and three ω-6 PUFAs, are higher in CM plasma. The ratios C20:4n-6/homo-γ-C20:3n-6 representative of delta-5-desaturases (D5D) and the elongase ratio are lower in esterified and unesterified CM plasma, respectively. In the CSF, the esterified D5D index is lower in CM. While PLA2 activity was similar, the plasma UFA to EFA ratio is higher in CM. Of all plasma GP/SPs detected, only ceramide levels are lower (p = 0.0003) in CM (0.26 ± 0.07%) compared to CT (0.48 ± 0.06%). The GP/SP proportion of platelet-activating factor (PAF) is significantly lower in CM CSF.ConclusionsPlasma and CSF lipid changes are consistent with abnormal lipid metabolism in CM. Since plasma UFAs correspond to diet or adipose tissue levels, higher plasma fatty acids and UFA/EFA ratios suggest enhanced adipose lipolysis in CM. Differences in plasma and CSF desaturases and elongases suggest altered lipid metabolism in CM. A lower plasma ceramide level suggests reduced de novo synthesis or reduced sphingomyelin hydrolysis. Changes in CSF PAF suggest differences in brain lipid signaling pathways in CM. Together, this pilot study shows lipid metabolic abnormality in CM corresponding to altered energy homeostasis. We propose that controlling plasma lipolysis, desaturases, elongases, and lipid signaling pathways may relieve CM symptoms.

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“…In addition, histological examination revealed that linoleic acid prevented neuronal damage, cell death, and reduction in neuron size in PD rat brains (Mbiydzenyuy et al, 2018). Oleic acid also protected against oxidative stress and restored DA and GSH levels in the brain of cytarabine‐treated rats (Calderón Guzmán et al, 2016). Oleic acid has been found to possess neuroprotective activity against transient and permanent focal cerebral ischemia, as well as global cerebral ischemia, which is attributed to its antiinflammatory activity through PPAR‐γ activation (Song et al, 2019).…”

Section: Resultsmentioning

confidence: 99%

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

Iranshahy

Javadi

Sahebkar

2022

Phytotherapy Research

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In Persian Medicine (PM), PD (brain‐based tremor) is a known CNS disorder with several therapeutic and preventive options. In their medical textbooks and pharmacopeias, Persian great scientists such as Rhazes (854–925 AD), Avicenna (980–1037 AD), and Jorjani (1042–1136 AD), have discussed pharmacological and nutritional strategies for the prevention, slowing progression, and treatment of PD. In the present study, we surveyed plant‐ and animal‐based foods recommended by PM for the prevention and treatment of CNS‐related tremors. In vivo and in‐vitro pharmacological evidence supporting the beneficial effects of PM‐recommended foods in prevention and alleviating PD, major active phytochemicals along with the relevant mechanisms of action were studied. Several PM plants possess potent antioxidant, antiinflammatory, and PD preventing properties. Garlic and allicin, cabbage and isothiocyanates, chickpea seed and its O‐methylated isoflavones biochanin A and formononetin, cinnamon, and cinnamaldehyde, saffron and its crocin, crocetin, and safranal, black cumin and its thymoquinone, black pepper and piperine, pistachio and genistein and daidzein, and resveratrol are among the most effective dietary itemsagainst PD. They act through attenuating neurotoxin‐induced memory loss and behavioral impairment, oxidative stress, and dopaminergic cell death. PM‐recommended foods can help alleviate PD progression and also discovering and developing new neuroprotective anti‐PD pharmaceuticals.

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Oleic Acid Protects Against Oxidative Stress Exacerbated by Cytarabine and Doxorubicin in Rat Brain

Abstract: These results suggest that the reduction of dopamine and oxidant effect during cytarabine treatment could result in brain injury but could be prevented by oleic acid supplementation.

Cited by 24 publications

References 0 publications

Preparation of Novel Nanoformulation to Enhance Efficacy in the Treatment of Cardiovascular Disease

Preparation of Novel Nanoformulation to Enhance Efficacy in the Treatment of Cardiovascular Disease

Plasma Lipolysis and Changes in Plasma and Cerebrospinal Fluid Signaling Lipids Reveal Abnormal Lipid Metabolism in Chronic Migraine

Protective effects of functional foods against Parkinson's disease: A narrative review on pharmacology, phytochemistry, and molecular mechanisms

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