Oleic Acid-induced Lung Injury: Thin-Section CT Evaluation in Dogs

Scillia, Pietro; Kafi, Sophia Abdel; Mélot, Christian; Keyzer, Caroline; Naeije, Robert; Gevenois, Pierre Alain

doi:10.1148/radiology.219.3.r01jn01724

Cited by 30 publications

(18 citation statements)

References 35 publications

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“…We could not completely exclude a possible influence of the instrumental apparatus used for the pneumoperitoneum induction on hemodynamics. Nevertheless, its impact on the edema formation, if any, is questionable because the excess tissue mass recorded under these conditions was similar or even smaller than previously reported (29,31).…”

Section: Oleic Acid-injured Lungsupporting

confidence: 45%

“…In the study group, we decided to investigate the aIAP effect at about 90 minutes after the oleic acid injection because at this time the oleic acid edema reaches the plateau (35)(36)(37)(38)(39)(40)(41)(42). However, after we observed the fast and dramatic increase of lung edema when raising aIAP, we performed another set of experiments to clearly define, in our own experimental setting, the natural course of oleic acid edema without any change of aIAP.…”

Section: Oleic Acid-injured Lungmentioning

confidence: 99%

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An Increase of Abdominal Pressure Increases Pulmonary Edema in Oleic Acid–induced Lung Injury

Quintel

Pelosi

Caironi

et al. 2004

Am J Respir Crit Care Med

169

108

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Increased abdominal pressure is common in intensive care unit patients. To investigate its impact on respiration and hemodynamics we applied intraabdominal pressure (aIAP) of 0 and 20 cm H 2 O (pneumoperitoneum) in seven pigs. The whole-lung computed tomography scan and a complete set of respiratory and hemodynamics variables were recorded both in healthy lung and after oleic acid (OA) injury. In healthy lung, aIAP 20 cm H 2 O significantly lowered the gas content, leaving the tissue content unchanged. In OAinjured lung at aIAP 0 cm H 2 O, the gas content significantly decreased compared with healthy lung. The excess tissue mass (edema) amounted to 30 Ϯ 24% of the original tissue weight (455 Ϯ 80 g). The edema was primarily distributed in the base regions and was not gravity dependent. Heart volume, central venous, pulmonary artery, wedge, and systemic arterial pressures significantly increased. At aIAP 20 cm H 2 O in OA-injured lung, the central venous and pulmonary artery pressures further increased. The gas content further decreased, and the excess tissue mass rose up to 103 Ϯ 37% (tissue weight 905 Ϯ 134 g), with homogeneous distribution along the cephalocaudal and sternovertebral axis. We conclude that in OAinjured lung, the increase of IAP increases the amount of edema.Keywords: intraabdominal pressure; acute respiratory distress syndrome; pulmonary edema; lung mechanics; computed tomography scanThe importance of intraabdominal pressure (IAP) in acute lung injury and acute respiratory distress syndrome has been recently suggested (1). For a long time any change in respiratory mechanics in patients with acute lung injury/acute respiratory distress syndrome was attributed to lung mechanics, whereas chest wall mechanics was assumed to be normal. However, few studies in which chest wall elastance was actually measured have showed that it was abnormal in a substantial proportion of patients with acute lung injury/acute respiratory distress syndrome (2-4). We (5) and others (6) have described different chest wall mechanics in patients with pulmonary and extrapulmonary acute respiratory distress syndrome, mainly due to different IAP values.However, apart from respiratory mechanics, the increased intrathoracic pressure caused by chest wall impairment may have important consequences on hemodynamics (7). We investigated the effect of changing IAP during controlled mechanical ventilation in healthy and diseased lungs. Surprisingly, the increase of IAP had an unexpected impact on lung edema, likely related to its formation and clearance. We wish to report our findings and METHODS(Additional details about Methods are provided in an online supplement.)The study group consisted of seven anesthetized and paralyzed domestic pigs (41 Ϯ 4 kg) ventilated throughout the experiment in supine position, with a Vt of 12 ml/kg, respiratory rate of 12-14 breaths/minute, positive end-expiratory pressure of 5 cm H 2 O, and Fi O 2 of 1.0. The animals were fully instrumented for hemodynamic monitoring (carotid artery, right atrium, mea...

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Section: Oleic Acid-injured Lungsupporting

confidence: 45%

Section: Oleic Acid-injured Lungmentioning

confidence: 99%

An Increase of Abdominal Pressure Increases Pulmonary Edema in Oleic Acid–induced Lung Injury

Quintel

Pelosi

Caironi

et al. 2004

Am J Respir Crit Care Med

169

108

View full text Add to dashboard Cite

show abstract

“…Intravenous OA produces a relatively diffuse edema as shown by thin-section computed tomography scan, more particularly in the few hours after injury (21). However, a moderate redistribution of blood flow occurs toward the spared ventral regions (22).…”

Section: Evlw By DI Methods In Normal Lung or After Oa Injurymentioning

confidence: 99%

Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury*

Roch

Michelet

Lambert

et al. 2004

Critical Care Medicine

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“…HRCT has been used for evaluating lung structures in sheep, pigs, rabbits, dogs, rats, and mice (78), and Micro HRCT scans of rats and mice can produce images with a spatial resolution of 50 to 100 μ (378). Previous studies have used HRCT to visualize regional distribution of edema after oleic acid injury in dogs (219,433), pigs (328,427), and mice (302). Scillia et al (433) obtained good agreement between thin section HRCT attenuation measurements of lung density with thermal dilution measurements of EVLW in dogs with either hydrostatic-or oleic acid-induced pulmonary edema.…”

Section: Lung Imaging To Assess Vascular Injurymentioning

confidence: 99%

“…Previous studies have used HRCT to visualize regional distribution of edema after oleic acid injury in dogs (219,433), pigs (328,427), and mice (302). Scillia et al (433) obtained good agreement between thin section HRCT attenuation measurements of lung density with thermal dilution measurements of EVLW in dogs with either hydrostatic-or oleic acid-induced pulmonary edema. Vertical gradients in the edema were found to differ between the hydrostatic and oleic acid injury groups.…”

Section: Lung Imaging To Assess Vascular Injurymentioning

confidence: 99%

Acute Lung Injury and Pulmonary Vascular Permeability: Use of Transgenic Models

Parker

2011

Comprehensive Physiology

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Acute lung injury is a general term that describes injurious conditions that can range from mild interstitial edema to massive inflammatory tissue destruction. This review will cover theoretical considerations and quantitative and semi-quantitative methods for assessing edema formation and increased vascular permeability during lung injury. Pulmonary edema can be quantitated directly using gravimetric methods, or indirectly by descriptive microscopy, quantitative morphometric microscopy, altered lung mechanics, high-resolution computed tomography, magnetic resonance imaging, positron emission tomography, or x-ray films. Lung vascular permeability to fluid can be evaluated by measuring the filtration coefficient (Kf) and permeability to solutes evaluated from their blood to lung clearances. Albumin clearances can then be used to calculate specific permeability-surface area products (PS) and reflection coefficients (σ). These methods as applied to a wide variety of transgenic mice subjected to acute lung injury by hyperoxic exposure, sepsis, ischemia-reperfusion, acid aspiration, oleic acid infusion, repeated lung lavage, and bleomycin are reviewed. These commonly used animal models simulate features of the acute respiratory distress syndrome, and the preparation of genetically modified mice and their use for defining specific pathways in these disease models are outlined. Although the initiating events differ widely, many of the subsequent inflammatory processes causing lung injury and increased vascular permeability are surprisingly similar for many etiologies.

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Oleic Acid-induced Lung Injury: Thin-Section CT Evaluation in Dogs

Cited by 30 publications

References 35 publications

An Increase of Abdominal Pressure Increases Pulmonary Edema in Oleic Acid–induced Lung Injury

An Increase of Abdominal Pressure Increases Pulmonary Edema in Oleic Acid–induced Lung Injury

Accuracy of the double indicator method for measurement of extravascular lung water depends on the type of acute lung injury*

Acute Lung Injury and Pulmonary Vascular Permeability: Use of Transgenic Models

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