Oleic Acid Coated Gelatin Nanoparticles Impregnated Gel for Sustained Delivery of Zaltoprofen: Formulation and Textural Characterization

Pawar, S.H.; Pande, Vishal

doi:10.15171/apb.2015.073

Cited by 15 publications

(5 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The area under the curve up to this point is taken as an indication of the consistency, which refers to “firmness”, “thickness”, or “viscosity” of a liquid or a semisolid. This test also provides an indication of viscosity, which is the result of the sample weight lifted mainly in the disc upper surface on its return, i.e., a measure of resistance to disk flow [54,55].…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles

et al. 2019

View full text Add to dashboard Cite

Bromelain, a set of proteolytic enzymes potential pharmaceutical applications, was encapsulated in chitosan nanoparticles to enhance enzyme stability, and the effect of different chitosan sources was evaluated. Chitosan types (i.e., low molecular weight chitosan, chitosan oligosaccharide lactate, and chitosan from shrimp shells) produced nanoparticles with different physicochemical properties, however in all cases, particle size and zeta potential decreased, and polydispersity index increased after bromelain addition. Bromelain encapsulation was higher than 84% and 79% for protein content and enzymatic activity, respectively, with low molecular weight chitosan presenting the highest encapsulation efficiency. Nanoparticle suspension was also tested for accelerated stability and rheological behavior. For the chitosan–bromelain nanoparticles, an instability index below 0.3 was recorded and, in general, the loading of bromelain in chitosan nanoparticles decreased the cohesiveness of the final suspension.

show abstract

Section: Resultsmentioning

confidence: 99%

“…It is related to product internal viscosity and is usually determined by measuring the force required to remove an item from product. In this test, maximum negative force is taken as an indication of the sample’s cohesiveness [54,55].…”

Section: Resultsmentioning

confidence: 99%

Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles

et al. 2019

View full text Add to dashboard Cite

show abstract

“… Group 4 (Blank hydrogel): One gram of hydrogel was applied topically to the right hind paw of inflamed irradiated rats. The area of application was occluded with bandages and left for 3 h, after which the remaining hydrogel was wiped off the hind paws (Pawar & Pande, 2015 ). Group 5 (Pure TNX hydrogel): 1% TNX hydrogel was applied to the inflamed irradiated rats by the same mode of application mentioned above.…”

Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats

et al. 2020

View full text Add to dashboard Cite

Transdermal delivery of non-steroidal anti-inflammatory drugs (NSAIDs) is an effective route of drug administration, as it directs the drug to the inflamed site with reduced incidence of systemic adverse effects such as gastric hemorrhage and ulcers. Tenoxicam (TNX) is a member of NSAIDs that are marketed only as oral tablets due to very poor absorption through the skin. The current study intended to formulate and characterize a hydrogel loaded with nanostructured lipid carriers (NLCs) to enhance the transdermal delivery of TNX. Six formulations of TNX were formulated by slight modifications of high shear homogenization and ultrasonication method. The selected formula was characterized for their particle size, polydispersity index (PDI), zeta potential, entrapment efficiency (EE), in-vitro drug release and ex-vivo skin permeation studies. Moreover, the effectiveness of the developed formula was studied in-vivo using carrageenan-induced paw edema and hyperalgesia model in irradiated rats. Formula F4 was chosen from six formulations, as the average diameter was 679.4 ± 51.3 nm, PDI value of about 0.02, zeta potential of À4.24 mV, EE of 92.36%, globules nanoparticles without aggregations and absence of interactions in the developed formula. Additionally, the in-vivo study showed the efficacy of formula F4 (TNX-NLCs hydrogel) equivalent to oral TNX in reducing the exaggerated inflammatory response induced by carrageenan after irradiation. In conclusion, the present findings suggest that TNX-NLCs hydrogel could be a potential transdermal drug delivery system alternative to the oral formulation for the treatment of various inflammatory conditions.

show abstract

“…Due to the diversity in nanomaterials, nano-based medicines have been proven to be promising next-generation therapeutics for advanced drug delivery [ 11 ]. The use of polymeric nanoparticles developed with synthetic, biodegradable polymers like poly (lactic acid) (PLA), poly (caprolactone) (PCL) and poly(lactic-co-glycolic acid) (PLGA) and natural polymers such as albumin, collagen, gelatin, fibroin, chitosan, and alginate are commonly reported in the literature [ 12 ]. Various lipid-based nano-formulations like nanostructured lipid carriers, liposomes and nanoemulsions are also being experimented with both in vitro and in-vivo.…”

Section: Introductionmentioning

confidence: 99%

Nanocarrier-Based Drug Delivery to Brain: Interventions of Surface Modification

Sharma

Dang

2023

View full text Add to dashboard Cite

Brain disorders are one of the prevalent and rapidly growing problems in the medical field as they adversely affect the quality of life of a human. With increase in life expectancy, it has been reported that diseaseslike Alzheimer’s, Parkinson’s, stroke and brain tumor along with neuropsychological disorders are also being reported at an alarmingly high rate. Despite various therapeutic being developed for the treatment of brain disorders, drug delivery to brain has been a challenging task because of the presence of a very complex Blood Brain Barrier, which precludes most of the drugs from entering the brain in effective concentrations. To overcome this barrier layer, nano- carrier based drug delivery systems have been reported widely by the researchers. These systems owing to their small size offer numerous advantages, however, their short residence time in body owing to opsonization poses a hinderance to their success in vivo. This review article focusses on the various aspects to modify the surfaces of these nano-carriers with polymers, surfactant, protein, antibodies, cell penetrating peptides, integrin binding peptides and glycoproteins such as transferrin & lactoferrin leading to enhanced residence time, desirable characteristics such as ability to cross blood brain barrier (BBB), increased bioavailability in regions of brain and targeted drug delivery.

show abstract

Oleic Acid Coated Gelatin Nanoparticles Impregnated Gel for Sustained Delivery of Zaltoprofen: Formulation and Textural Characterization

Cited by 15 publications

References 28 publications

Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles

Effect of Polysaccharide Sources on the Physicochemical Properties of Bromelain–Chitosan Nanoparticles

Effect of nanostructured lipid carriers on transdermal delivery of tenoxicam in irradiated rats

Nanocarrier-Based Drug Delivery to Brain: Interventions of Surface Modification

Contact Info

Product

Resources

About