Oleic Acid-associated Bronchiolitis Obliterans-organizing Pneumonia in Beagle Dogs

Li, X.; Botts, Suzanne; Dl, Morton; Knickerbocker, M. J.; Adler, Richard H.

doi:10.1354/vp.43-2-183

Cited by 14 publications

(11 citation statements)

References 12 publications

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“…Heated soybean oil may itself be a risk factor, in light of recent studies showing the deleterious eVects of oleic acid in the lungs of dogs (Li et al 2006). Oleic and linoleic acid, fatty acids present to a signiWcant degree in soybean oil, have been shown to be respiratory irritants (Khan et al 1991) and have been suggested as models for BOOP and BO in humans.…”

Section: Discussionmentioning

confidence: 99%

Popcorn lung and bronchiolitis obliterans: a critical appraisal

Galbraith¹,

Weill

2008

Int Arch Occup Environ Health

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Section: Discussionmentioning

confidence: 99%

Popcorn lung and bronchiolitis obliterans: a critical appraisal

Galbraith¹,

Weill

2008

Int Arch Occup Environ Health

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“…heme oxygenase, nitric oxide synthase) that regulate microvascular dilation and participate in the oxygen burst of reperfusion injury have been shown to induce BOOP changes. (43, 56) These reports imply that the simplest system for studying the development of BOOP may not require alteration of the immune response, but controlled ischemia. The ideal model would reproduce BO reliably, avoid alteration of immune tolerance, affect only one lung, and leave the airways patent.…”

Section: Discussionmentioning

confidence: 99%

Rattus Model Utilizing Selective Pulmonary Ischemia Induces Bronchiolitis Obliterans Organizing Pneumonia

Densmore¹,

Jeziorczak²,

Clough³

et al. 2013

Shock

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Background Bronchiolitis obliterans organizing pneumonia (BOOP), a morbid condition when associated with lung transplant and chronic lung disease, is believed to be a complication of ischemia. Our goal was to develop a simple and reliable model of lung ischemia in the Sprague-Dawley rat that would produce BOOP. Methods Unilateral ischemia without airway occlusion was produced by an occlusive slipknot placed around the left main pulmonary artery. Studies were performed 7 days later. Relative pulmonary and systemic flow to each lung was measured by injection of 99mTc-macroaggregated albumin. Histological sections were examined for structure and necrosis and scored for BOOP. Apoptosis was detected by immunohistochemistry with an antibody against cleaved caspase-3. Results Pulmonary artery blood flow to left lungs was <0.1% of the cardiac output, and bronchial artery circulation was ~2% of aortic artery flow. Histological sections from ischemic left lungs consistently showed Masson bodies, inflammation and young fibroblasts filling the distal airways and alveoli, consistent with BOOP. Quantitative evaluation of BOOP using epithelial changes, inflammation and fibrosis were higher in ischemic left lungs than right or sham-operated left lungs. Apoptosis was increased in areas exhibiting histological BOOP, but there was no histological evidence of necrosis. TLR4 expression was increased in ischemic left lungs over right. Conclusions An occlusive slipknot around the main left PA in rats produces BOOP, providing direct evidence that ischemia without immunomodulation or coinfection is sufficient to initiate this injury. It also affords an excellent model to study signaling and genetic mechanisms underlying BOOP.

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“…Experimentally infected dogs with adenovirus [42][43][44], Mycoplasma [45], or cattle clinical infected bovine respiratory syncytial virus pneumonia occasionally develop BOOP [46]. Accidental intra-airway exposure of dog with a noninfectious agent oleic acid also induced BOOP [47]. Majeski at al.…”

Section: Discussionmentioning

confidence: 99%

Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection

Cheng

Lee

Lin

et al. 2010

BioMed Research International

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Bronchiolitis obliterans organizing pneumonia (BOOP) is a chronic respiratory disease. Although the pathogenesis of BOOP is still incompletely understood, BOOP is responsive to steroids and has a good prognosis. In our five pigs with chronic postweaning multisystemic wasting syndrome (PMWS), typical BOOP lesions were revealed. All five porcine lungs showed typical intraluminal plugs, and porcine circovirus type 2 (PCV2) was identified. They also exhibited similar pathologic findings such as proliferation of type II pneumocytes and myofibroblasts (MFBs), extracellular collagen matrix (ECM) deposition, and fragmentation of elastic fibers. MFBs migration correlative molecules, for instance, gelatinase A, B and osteopontin, appeared strongly in the progressing marginal area of polypoid intraluminal plugs of fibrotic lesion. These molecules colocalized with the active MFBs. Both gelatinase activity and intercellular level of active MFBs were significantly increased (P < .05). Porcine chronic bronchopneumonia leads to BOOP and it is associated with PCV2 persistent infection. Swine BOOP demonstrates similar cellular constituents with human BOOP. Perhaps their molecular mechanisms of pathogenesis operate in a similar way. Thus we infer that the swine BOOP can be considered as a potential animal model for human BOOP associated with natural viral infection. Moreover, it is more convenient to obtain samples.

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Oleic Acid-associated Bronchiolitis Obliterans-organizing Pneumonia in Beagle Dogs

Cited by 14 publications

References 12 publications

Popcorn lung and bronchiolitis obliterans: a critical appraisal

Popcorn lung and bronchiolitis obliterans: a critical appraisal

Rattus Model Utilizing Selective Pulmonary Ischemia Induces Bronchiolitis Obliterans Organizing Pneumonia

Bronchiolitis Obliterans Organizing Pneumonia in Swine Associated with Porcine Circovirus Type 2 Infection

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