Olefin and Acetylene Complexes of Transition Metals.

Click Chemistry, A Powerful Tool for Pharmaceutical Sciences

“…Knowing that other transition metals can insert into alkynes (19,20), Golas et al reacted propargyl ether with azide-terminated polystyrene to make polymers using three different catalyst: NiCl 2 , PtCl 2 , and PdCl 2 (13). Although none of them displayed catalytic activity as high or as fast as CuBr, they all produced polymerization products.…”

Aqueous Access Channels in Subunit a of Rotary ATP Synthase

“…In this experimental system, we have shown by atomic absorption analysis that 80% of silver added to membrane vesicles becomes complexed with the membrane. Conceivably, the silver may be transported to the interior of the membrane vesicles, where it gains access to subunit a. Alternatively, the silver may bind to other membrane proteins or sites of unsaturation on fatty acid tails (71,72). To test whether other proteins in the membrane were transporting silver or were necessary for silver absorption by the membrane, F 1 F o was purified and reconstituted into liposomes and tested for Ag and Cys 215 mutant enzymes still exhibited inhibition by Ag ϩ , suggesting that the silver may gain access to these cysteines without the aid of other membrane proteins and that the inhibitory Ag ϩ does not need to be transported to the interior of these vesicles by an inner membrane Ag ϩ transport system.…”

Model of the Antimicrobial Silver Uracil

“…This, according to Bennett [8], gave a value of 20-30 kcal for the sil ver olefin bond energy. This is an attractive explanation to explain the formation of the secondary product after stirring.…”