Olecranon bursitis secondary to Mycobacterium kansasii infection in a patient receiving infliximab for Behçet's disease

Malkin, Joanne; Shrimpton, Anna; Wiselka, Martin; Barer, Michael R.; Duddridge, M; Perera, Nelun

doi:10.1099/jmm.0.006809-0

Cited by 23 publications

(10 citation statements)

References 18 publications

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“…Similar to tuberculosis, NTM could have a broad range of radiological patterns including nodular or pseudo-nodular lesions, parenchymal consolidation, cavitary lesions, pleural thickenings, and pleural effusions, or a mixed pattern [33][34][35].…”

Section: Acute Infectious Processesmentioning

confidence: 99%

PET/CT in nononcological lung diseases: current applications and future perspectives

et al. 2016

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Positron emission tomography (PET) combined with computed tomography (CT) is an established diagnostic modality that has become an essential imaging tool in oncological practice. However, thanks to its noninvasive nature and its capability to provide physiological information, the main applications of this technique have significantly expanded. 18F-labelled fluorodeoxyglucose (FDG) is the most commonly used radiopharmaceutical for PET scanning and demonstrates metabolic activity in various tissues. Since activated inflammatory cells, like malignant cells, predominantly metabolise glucose as a source of energy and increase expression of glucose transporters when activated, FDG-PET/CT can be successfully used to detect and monitor a variety of lung diseases, such as infections and several inflammatory conditions.The added value of FDG-PET/CT as a molecular imaging technique relies on its capability to identify disease in very early stages, long before the appearance of structural changes detectable by conventional imaging. Furthermore, by detecting the active phase of infectious or inflammatory processes, disease progression and treatment efficacy can be monitored. This review will focus on the clinical use of FDG-PET/CT in nonmalignant pulmonary diseases. @ERSpublications PET/CT is an imaging modality that could play a role in evaluation of inflammatory and infectious lung diseases

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Section: Acute Infectious Processesmentioning

confidence: 99%

PET/CT in nononcological lung diseases: current applications and future perspectives

et al. 2016

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“…There were two other published case reports of nonpulmonary M. kansasii infections (skin lesions and olecranon bursitis) in patients treated with anti-TNF-alpha agents (Table 2) [19, 20]. A case of 18 F-FDG PET-positive solitary pulmonary nodule from M. kansasii infection in an immunocompetent host was reported in the literature [18].…”

Section: Discussionmentioning

confidence: 99%

PulmonaryMycobacterium kansasiiInfection Mimicking Malignancy on the¹⁸F-FDG PET Scan in a Patient Receiving Etanercept: A Case Report and Literature Review

Min

Amlani

2014

Case Reports in Pulmonology

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A 66-year-old male presented with chest pain, malaise, generalized weakness, and weight loss. He had been receiving etanercept injection for rheumatoid arthritis. Chest X-ray revealed a right upper lobe mass. Chest computed tomography (CT) showed a right apical mass, highly suggestive of a Pancoast tumor. The thoracic fluorine-18 fluoro-deoxy-glucose (18F-FDG) positron emission tomography (PET) scan demonstrated significantly high metabolic pulmonary lesions with the standardized uptake value (SUV) of 12.5, consistent with lung cancer. The patient underwent bronchoscopy and bronchoalveolar lavage (BAL). BAL cytology was negative for malignant cells. BAL acid fast bacilli (AFB) smears were positive, and Mycobacterium kansasii was eventually isolated. He received a 12-month course of rifampin, isoniazid, and ethambutol. Interval resolution of pulmonary lesions was noted on follow-up serial CT chest studies. There has been increasing incidence of nontuberculous mycobacterial infections reported in patients treated with the antitumor necrosis factor-alpha (anti-TNF-alpha) agents. Infectious foci have an increased glucose metabolism which potentially causes a high FDG uptake on the 18F-FDG PET scan, leading to undue anxiety and cost to the patients. This is the first reported case of pulmonary M. kansasii infection with a positive thoracic 18F-FDG PET study mimicking malignancy in a patient on etanercept.

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“…This condition has been related to treatment for this disease, usually consisting of a combination of systemic corticosteroids and an immunosuppressive drug like azathioprine or cyclosporine as first line approach [151][152][153][154][155][156][157][158][159][160][161][162][163].…”

Section: Resultsmentioning

confidence: 99%

Behcet’s disease: from heat shock proteins to infections

2014

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Background: Behcet's disease (BD) is a chronic, inflammatory multisystemic condition of unknown etiology. Although the cause of BD is not clear, it is believed to be the result of an autoimmune process triggered by an infectious or environmental agent (possibly local to a geographic region) in a genetically predisposed individual. Objective: To detail current knowledge of the role of microorganisms in the pathogenesis of BD and review the infectious etiology of this disease. Methods: The review based on publication in SCOPUS, Science direct, and PubMed. Results: A microbial infection has been implicated in the development of the disease to explain the strong inflammatory reactions observed, the activation of monocytes and macrophages, and the induction of proinflammatory cytokines and chemokines detected. Common factors linking some of the possible pathogenetic agents are extrinsically induced tissue stress or heat shock proteins, which react with host tissues and elicit significant T-helper type 1 cell responses. Conclusion: Based on collected data, we conclude that the microorganisms discussed seem to participate and, at least in part, act as triggers during the course of BD. By clarifying the microbial associations of BD and finding its etiology, particularly the causative antigens leading to BD, it would be easier to suggest more effective treatment and preventive strategies for this disease.

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Olecranon bursitis secondary to Mycobacterium kansasii infection in a patient receiving infliximab for Behçet's disease

Cited by 23 publications

References 18 publications

PET/CT in nononcological lung diseases: current applications and future perspectives

PET/CT in nononcological lung diseases: current applications and future perspectives

PulmonaryMycobacterium kansasiiInfection Mimicking Malignancy on the¹⁸F-FDG PET Scan in a Patient Receiving Etanercept: A Case Report and Literature Review

Behcet’s disease: from heat shock proteins to infections

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Olecranon bursitis secondary to Mycobacterium kansasii infection in a patient receiving infliximab for Behçet's disease

Cited by 23 publications

References 18 publications

PET/CT in nononcological lung diseases: current applications and future perspectives

PET/CT in nononcological lung diseases: current applications and future perspectives

PulmonaryMycobacterium kansasiiInfection Mimicking Malignancy on the18F-FDG PET Scan in a Patient Receiving Etanercept: A Case Report and Literature Review

Behcet’s disease: from heat shock proteins to infections

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PulmonaryMycobacterium kansasiiInfection Mimicking Malignancy on the¹⁸F-FDG PET Scan in a Patient Receiving Etanercept: A Case Report and Literature Review