Oleate Inhibits Exocrine Pancreatic Secretion

Present Status of the Anticholecystokinin Hormone

“…The name 'pancreatone' was proposed for this can didate hormone (7). In man, Voirol et al (16) reported that when oleic acid was injected into the ileum but not into the duodenum, jejunum, colon or rectum, the CCK-induced secretion of pancreatic enzymes was inhibited. In conscious rats provided with a new type o f duodenal cannula permetting normal flow o f pancreatic juice between experiments, the bile duct being ligated, an intraduodenal injection o f oleic acid (2 ml in 60 min) causes an immediate increase o f water, bicarbonate and protein secretion and a strongly delayed inhibition o f protein concen tration and output (respectively -63 and -57% o f basal values at 150 min).…”