Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells

Li, Yuyi; Xu, Qian-Fei; Yang, Wei; Wu, Tongli; Lu, Xirong

doi:10.1016/j.gene.2019.143956

Cited by 43 publications

(33 citation statements)

References 34 publications

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“…31 A high level of glycolysis produces a large amount of lactic acid, which can cause decreased pH value in the microenvironment of tumor cells, thereby improving the proliferation ability of tumor cells. 32 After miR-153-3p mimic transfection, cell proliferation, invasion and glycolysis of thyroid cancer was suppressed in this study. Therefore, miR-153-3p mimic could reduce the ability of thyroid cells to produce and transport lactic acid, that is, inhibit the tumor's glycolysis ability and interfere with malignant behavior.…”

Section: Discussionmentioning

confidence: 64%

MiR-153-3p Suppresses Cell Proliferation, Invasion and Glycolysis of Thyroid Cancer Through Inhibiting E3F3 Expression

Deng

Guo

Fan

2021

OTT

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The aim was to research the role of miR-153-3p and E2F3 in the development of thyroid tumors. Methods: A total of 91 thyroid cancer patients were involved. The role of miR-153-3p in THCA cell lines and Nthy-ori3-1 cell line was researched. qPCR was used to detect miR-153-3p and E2F3 expression. MiR-153-3p mimic, inhibitor, siE2F3 or corresponding controls were transfected in cells. CCK8 was used to verify the proliferation. Cell cycle and apoptosis was detected by flow cytometry. Transwell assay was applied for migration and invasion, and glycolysis was monitored. The binding of miR-153-3p and E2F3 was predicted by targetscan database, and verified by luciferase reporter and RNA-pull down assay. Western blot was used to detect E2F3 expression. Rescue assay was undertaken to verify the effect of siE2F3 on miR-153-3p inhibitor. Moreover, the effect of miR-153-3p mimic on tumor volume and weight was measured. IHC assay was processed to E2F3 and Ki67 expression, and TUNEL assay was used for apoptosis. Results: MiR-153-3p expressed lower in thyroid tumors and cells. The level of miR-153-3p was negatively related with TNM stage. MiR-153-3p inhibited cell proliferation, invasion migration, and induced cycle arrest and apoptosis. Moreover, it negatively regulated E2F3. siE2F3 rescued effects of miR-153-3p inhibitor in all above biological processes in thyroid cancer cells. MiR-153-3p inhibited tumor growth. Moreover, it inhibited E2F3 and Ki67 expression, and also increased apoptosis in vivo. Conclusion: MiR-153-3p suppresses cell proliferation, invasion and glycolysis of thyroid cancer through inhibiting E3F3 expression, which may be a biomarker for thyroid cancer diagnose.

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Section: Discussionmentioning

confidence: 64%

MiR-153-3p Suppresses Cell Proliferation, Invasion and Glycolysis of Thyroid Cancer Through Inhibiting E3F3 Expression

Deng

Guo

Fan

2021

OTT

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“…22 Glycolytic rate-limiting enzymes and hypoxia-inducible factors are expected to become new targets for cancer treatment. 23 Therefore, we hypothesize that these target lncRNAs may play an indispensable role in cancer metabolic pathways, and our analysis may provide potential useful biomarkers for cancer treatment.…”

Section: Discussionmentioning

confidence: 94%

Autophagy-related long non-coding RNA signature for ovarian cancer

2020

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Objective Ovarian cancer (OC) affects nearly 22,000 women annually in the United States and ranks fifth in cancer deaths, largely because of being diagnosed at an advanced stage. Autophagy is the cellular process of self-degrading damaged or degenerate proteins and organelles. Long non-coding RNAs (lncRNAs) are a group of RNA molecules whose transcripts are greater than 200 nt but are not translated into proteins. However, just a small number of autophagy-related lncRNAs have been explored in depth. Methods We used RNA sequencing data from The Cancer Genome Atlas (TCGA) and autophagy datasets to identify dysfunctional autophagy-related lncRNAs and provide potential useful biomarkers for OC diagnosis and prognosis. Results Seventeen differentially expressed lncRNAs (AC010186.3, AC006001.2, LBX2-AS1, SNHG17, AC011445.1, AC083880.1, MIR193BHG, AC025259.3, HCG14, AC007114.1, AC108673.2, USP30-AS1, AC010336.5, LINC01132, AC006333.2, LINC00665 and AC027348.1) were selected as independent prognostic factors for OC patients. Functional annotation of the data was performed through gene set enrichment analysis (GSEA). The results suggested that the high-risk group was mainly enriched in specific tumor-related and metabolism pathways. Conclusion Based on the online databases, we identified novel autophagy-related lncRNAs for the prognosis of ovarian cancer.

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“…OA is one of the most abundant triterpenoids in plants and possesses antitumor activity in many cancer lines, such as liver cancer [ 19 ], thyroid cancer [ 20 ], lung cancer [ 21 ], cervical cancer [ 22 ], and gastric cancer [ 23 ]. At present, there are many reports on the treatment of liver cancer with OA.…”

Section: Pharmacological Effects Of Oa and Its Derivativesmentioning

confidence: 99%

Development and Evaluation of Oleanolic Acid Dosage Forms and Its Derivatives

Feng

Yang

Sun

et al. 2020

BioMed Research International

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Oleanolic acid is a pentacyclic triterpenoid compound that exists widely in medicinal herbs and other plants. Because of the extensive pharmacological activity, oleanolic acid has attracted more and more attention. However, the structural characteristics of oleanolic acid prevent it from being directly made into new drugs, which limits the application of oleanolic acid. Through the application of modern preparation techniques and methods, different oleanolic acid dosage forms and derivatives have been designed and synthesized. These techniques can improve the water solubility and bioavailability of oleanolic acid and lay a foundation for the new drug development. In this review, the recent progress in understanding the oleanolic acid dosage forms and its derivatives are discussed. Furthermore, these products were evaluated comprehensively from the perspective of characterization and pharmacokinetics, and this work may provide ideas and references for the development of oleanolic acid preparations.

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Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells

Cited by 43 publications

References 34 publications

MiR-153-3p Suppresses Cell Proliferation, Invasion and Glycolysis of Thyroid Cancer Through Inhibiting E3F3 Expression

MiR-153-3p Suppresses Cell Proliferation, Invasion and Glycolysis of Thyroid Cancer Through Inhibiting E3F3 Expression

Autophagy-related long non-coding RNA signature for ovarian cancer

Development and Evaluation of Oleanolic Acid Dosage Forms and Its Derivatives

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