Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation

Han, Yuwei; Tong, Zhenhua; Wang, Chenchen; Li, Xiaoming; Liang, Guobiao

doi:10.1016/j.ejphar.2020.173811

Cited by 27 publications

(24 citation statements)

References 32 publications

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“…Thereby ST could be a potential drug for the treatment of obesity and obesity-related metabolic disorders such as stoke and coronary heart disease, which is a hot research topic at the moment. Furthermore, oleanolic acid has been shown to have neuroprotective effects in rats with subarachnoid hemorrhage via SIRT1-mediated deacetylation of HMGB1 ( Han et al, 2021 ). At the same time, oleanolic acid pretreatment also reduce ischemia-reperfusion injury in mice, reflecting its cerebroprotective effect ( Shi et al, 2021 ).…”

Section: Phytochemical Constituentsmentioning

confidence: 99%

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Yuan

et al. 2021

Front. Pharmacol.

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In recent years, the incidence and mortality of cardio-cerebrovascular diseases have been increasing year by year, which has become global burden and challenge. Based on the holistic thinking of “brain disease affects the heart” and “heart disease affects the brain,” as well as the characteristics of multi-target and multi-path effects of Chinese medicine, Chinese medicine is more advantageous in the treatment of cardio-cerebrovascular diseases. As a botanical medicine, storax is known for its resuscitation, filth avoidance and pain-relieving effects in the treatment of cardio-cerebrovascular diseases. By reviewing and collating the relevant domestic and international literature in the past 10 years, we have sorted out an overview of the medicinal parts, traditional uses and chemical composition of storax. For the first time, based on the idea of “cerebral and cardiac simultaneous treatment,” the pharmacological activities and mechanisms of heart and brain protection of storax for treating cardio-cerebrovascular diseases were summarized and analyzed, showing that storax has the pharmacological effects of anti-cerebral ischemia, regulation of blood-brain barrier, bidirectional regulation of the central nervous system, anti-myocardial ischemia, anti-arrhythmia, anti-thrombosis and anti-platelet aggregation. It mainly exerts its protective effects on the brain and heart through mechanisms such as inhibition of inflammatory immune factors, anti-oxidative stress, anti-apoptosis, pro-neovascularization and regulation of NO release. On the basis of the current findings and limitations, the future research strategies and perspectives of storax are proposed, with a view to providing a reference for further application and development of this medicine, as well as contributing new thoughts and visions for the clinical application of “treating brain-heart synchronously”.

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Section: Phytochemical Constituentsmentioning

confidence: 99%

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Yuan

et al. 2021

Front. Pharmacol.

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“…With Notch1 knockdown, Ole induced LC3B proteins changing was recovery in HaCaT cell psoriasis model. As a natural pentacyclic triterpenoid, Ole has been reported to exert antitumor and anti-inflammatory effects (Wang et al 2019;Abdelmageed et al 2017), and has been shown to be effective in the treatment of multiple types of tumor (Chu et al 2017;Dong et al 2020;Han et al 2021). The results of the present study revealed that Ole intervention could effectively inhibit the abnormal proliferation of HaCaT cells induced by IL-22 stimulation and promote their apoptosis, which may subsequently inhibit the development of psoriasis.…”

Section: Expression Levels Of Lc3b Protein In Hacat Cell Psoriasis Modelmentioning

confidence: 54%

Role of oleanolic acid in relieving psoriasis and its underlying mechanism of action

et al. 2022

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“…Betulinic acid showed significant PTP1B inhibitory activity, with IC 50 values of 3.5 μM [24]. [54] Anti-hypertension (in vivo) [55] Anti-tumor (in vitro) [56,57] Neuroprotection(in vitro) [58] Anti-cholesterol(in vitro) […”

Section: Lupane Triterpenoidsmentioning

confidence: 99%

“…It was found from callus tissue from the stems of A. arguta , together with 2 α ,3 β -dihydroxyolean-12-en-28-oic acid 78 [ 26 ]. Oleanolic acid 77 is abundant in nature and exhibits a wide range of biological activities including anti-inflammatory [ 54 ], anti-hypertension [ 55 ], anti-tumor [ 56 , 57 ], neuroprotection [ 58 ], and anti-cholesterol activities [ 59 ]. Oleanolic acid was performed to test the effect on apoptosis and autophagy of SMMC-7721 Hepatoma cells.…”

Section: Chemical Constituentsmentioning

confidence: 99%

“… Part Bioactivity Refs. 77 Oleanolic acid A. arguta [ 26 ] Stems Anti-inflammatory (in vitro) [ 54 ] Anti-hypertension (in vivo) [ 55 ] Anti-tumor (in vitro) [ 56 , 57 ] Neuroprotection(in vitro) [ 58 ] Anti-cholesterol(in vitro) [ 59 ] 78 2 α ,3 β -Dihydroxyolean-12-en-28-oic acid A. arguta [ 26 ] Stems 79 2 α ,3 α -Dihydroxyolean-12-en-28-oic acid A. chinensis Planch [ 63 ] Fruits 80 2 α ,3 β ,23-Trihydroxyolean-12-en-28-oic acid A. deliciosa [ 31 ] Peels Antifungal (in vitro) [ 31 ] 81 2 α ,3 α ,24-Trihydroxyolean-12-en-28-oic acid A. deliciosa [ 31 ] Peels Antifungal (in vitro) [ 31 ] 82 3 β -O-Acetyloleanolic acid A. arguta [ 64 ] A. chinensis [ 45 ] Stems Roots Anti-angiogenesis (in vitro) [ 45 ] 83 …”

Section: Chemical Constituentsmentioning

confidence: 99%

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Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia

Liu

et al. 2021

Nat. Prod. Bioprospect.

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Kiwi, a fruit from plants of the genus Actinidia, is one of the famous fruits with thousand years of edible history. In the past twenty years, a great deal of research has been done on the chemical constituents of the Actinidia species. A large number of secondary metabolites including triterpenoids, flavonoids, phenols, etc. have been identified from differents parts of Actinidia plants, which exhibited significant in vitro and in vivo pharmacological activities including anticancer, anti-inflammatory, neuroprotective, anti-oxidative, anti-bacterial, and anti-diabetic activities. In order to fully understand the chemical components and biological activities of Actinidia plants, and to improve their further research, development and utilization, this review summarizes the compounds extracted from different parts of Actinidia plants since 1959 to 2020, classifies the types of constituents, reports on the pharmacological activities of relative compounds and medicinal potentials.

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Oleanolic acid exerts neuroprotective effects in subarachnoid hemorrhage rats through SIRT1-mediated HMGB1 deacetylation

Cited by 27 publications

References 32 publications

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Storax, A Promising Botanical Medicine for Treating Cardio-Cerebrovascular Diseases: A Review

Role of oleanolic acid in relieving psoriasis and its underlying mechanism of action

Advances in Research on Chemical Constituents and Their Biological Activities of the Genus Actinidia

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