Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes

Kurek, Anna; Grudniak, Anna M.; Szwed, Magdalena; Klicka, Anna; Samluk, Łukasz; Wolska, Krystyna I.; Janiszowska, Wirginia; Popowska, Magdalena

doi:10.1007/s10482-009-9388-6

Cited by 66 publications

(59 citation statements)

References 31 publications

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“…The final study suggests the eventual stimulation of murein hydrolases [78] by OA can result in increased degradation of this macromolecule. A detailed study of the effects of OA and UA on peptidoglycan (murein) content, turnover and the autolysis of L. monocytogenes was published recently [79]. In this species, the causative agent of listeriosis is a facultative pathogen able to survive and multiply in macrophages [80].…”

Section: Cellular Targets and Functions Affected By Oa Ua And Their mentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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Bacterial resistance to antibiotics is increasing at an alarming rate and many commonly used antibiotics are no longer effective.Thus, there is considerable interest in investigating novel antibacterial compounds, such as the plant-derived pentacyclic triterpenoids, including oleanolic acid (OA), ursolic acid (UA) and their derivatives. These compounds can be isolated from many medicinal and crop plants and their antibacterial, antiviral, antiulcer and anti-inflammatory effects are well documented. OA and UA are active against many bacterial species, particularly Gram-positive species, including mycobacteria. They inhibit bacterial growth and survival, and the spectrum of minimal inhibitory concentration (MIC) values is very broad. In addition, OA, UA and their derivatives display potent antimutagenic activity. Studies to identify the cellular targets and molecular mechanisms of OA and UA action were initiated a few years ago and it has already been demonstrated that both acids influence bacterial gene expression, the formation and maintenance of biofilms, cell autolysis and peptidoglycan turnover. Before these compounds can be used clinically as antimicrobial agents, further extensive studies are required to determine their cytotoxicity and the optimum mode of their application.

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Section: Cellular Targets and Functions Affected By Oa Ua And Their mentioning

confidence: 99%

Antibacterial activity of oleanolic and ursolic acids and their derivatives

et al. 2010

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“…Moreover, L. monocytogenes had lower OD values as oleanolic acid concentration increased (Tables 1-3). Inhibited growth of L. monocytogenes may be related to impaired peptidoglycan metabolism caused by oleanolic acid because the triterpenoids of oleanolic acid may influence the enzymes related to peptidoglycan metabolism such as the proteins involved in cell wall synthesis, hydrolysis and modification which might decrease peptidoglycan cross-linkage and thus enhance its susceptibility to mutanolysin, an N-acetylmuramidase (Kurek et al, 2010).…”

Section: Resultsmentioning

confidence: 99%

Antimicrobial Activity of Oleanolic Acid on Listeria monocytogenes under Sublethal Stresses of NaCl and pH

Yoon¹,

Choi²

2010

Korean Journal for Food Science of Animal Resources

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“…Previously, it has been reported that OA inhibited peptidoglycan metabolism in L. monocytogenes, resulting in the im-paired proliferation of the bacterial cells [10]. Therefore, it is necessary to examine if same mechanism applies to the case of S. mutans by OA addition.…”

Section: Resultsmentioning

confidence: 99%

Identification of Inhibitory Effect on Streptococcus mutans by Oleanolic Acid

Yoon¹,

Choi

2010

Journal of Life Science

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Among endogenous oral microflora, Streptococcus mutans plays a critical role in dental plaque formation, which mainly contributes to the development of caries and periodontal disease. Phytochemicals are plant-derived chemical compounds that have been studied as beneficial nutrients to human health. The purpose of this study was to determine the effects of phytochemicals against S. mutans. Among them, oleanolic acid (OA) and 5-(hydroxymethyl)-2-furfural (HF) from Thomson seedless raisins were tested for anti-microbial effects against various clinically important bacteria. OA inhibited the growth of Gram-positive bacteria, but not Gram-negative bacteria. However, HF did not display any antibacterial effect against any of the strains tested. OA also exhibited inhibitory effects in surface adherence and biofilm formation of S. mutans. The results suggest that OA can be utilized as a potential anti-plaque and anti-caries agent by controlling the physiological characteristics of S. mutans on teeth.

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Oleanolic acid and ursolic acid affect peptidoglycan metabolism in Listeria monocytogenes

Cited by 66 publications

References 31 publications

Antibacterial activity of oleanolic and ursolic acids and their derivatives

Antibacterial activity of oleanolic and ursolic acids and their derivatives

Antimicrobial Activity of Oleanolic Acid on Listeria monocytogenes under Sublethal Stresses of NaCl and pH

Identification of Inhibitory Effect on Streptococcus mutans by Oleanolic Acid

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