Oleanolic Acid and Ursolic Acid in Commercial Dried Fruits

Zhang, Feng; Daimaru, Eisuke; Ohnishi, Masao; Kinoshita, Mikio; Tokuji, Yoshihiko

doi:10.3136/fstr.19.113

Cited by 23 publications

(11 citation statements)

References 14 publications

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“…Therefore, oleanolic acid content is much higher in fruit “skin” or “peel” (non-botanical terms which include cuticle and multiple cell types) in comparison with the pulp (Table 1). In general, fruits which are consumed with the skin, including dried fruits, can be better dietary sources of oleanolic acid [26]. The most important sources of oleanolic acid in human diet are olives ( Olea europaea L.), from which the compound derives its name, and their products, such as olive oil [27].…”

Section: Sources and Bioavailabilitymentioning

confidence: 99%

“…Comparative analysis of 38 commercial herbal extracts showed the presence of oleanolic acid in extracts of Aesculus hyppocastanum L., Crataegus monogyna L., Harpagophytum procumbens DC, Lagerstroemia speciosa L., Ortosiphon stamineus L., Punica granatum L., Styrax benzoin Dryand., Vaccinium myrtillus L. and Vitis vinifera L. [37]. Oleanolic acid is also detected in propolis [37] and numerous plant-based products, including spices [38,39], vegetable oil [27], and snack products, containing dried whole fruits [26]. …”

Section: Sources and Bioavailabilitymentioning

confidence: 99%

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Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Žiberna

Šamec

Mocan

et al. 2017

IJMS

115

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Nowadays, much attention has been paid to diet and dietary supplements as a cost-effective therapeutic strategy for prevention and treatment of a myriad of chronic and degenerative diseases. Rapidly accumulating scientific evidence achieved through high-throughput technologies has greatly expanded the understanding about the multifaceted nature of cancer. Increasingly, it is being realized that deregulation of spatio-temporally controlled intracellular signaling cascades plays a contributory role in the onset and progression of cancer. Therefore, targeting regulators of oncogenic signaling cascades is essential to prevent and treat cancer. A plethora of preclinical and epidemiological evidences showed promising role of phytochemicals against several types of cancer. Oleanolic acid, a common pentacyclic triterpenoid, is mainly found in olive oil, as well as several plant species. It is a potent inhibitor of cellular inflammatory process and a well-known inducer of phase 2 xenobiotic biotransformation enzymes. Main molecular mechanisms underlying anticancer effects of oleanolic acid are mediated by caspases, 5 adenosine monophosphate-activated protein kinase, extracellular signal-regulated kinase 1/2, matrix metalloproteinases, pro-apoptotic Bax and bid, phosphatidylinositide 3-kinase/Akt1/mechanistic target of rapamycin, reactive oxygen species/apoptosis signal-regulating kinase 1/p38 mitogen-activated protein kinase, nuclear factor-κB, cluster of differentiation 1, CKD4, s6k, signal transducer and activator of transcription 3, as well as aforementioned signaling pathways . In this work, we critically review the scientific literature on the molecular targets of oleanolic acid implicated in the prevention and treatment of several types of cancer. We also discuss chemical aspects, natural sources, bioavailability, and safety of this bioactive phytochemical.

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Section: Sources and Bioavailabilitymentioning

confidence: 99%

Section: Sources and Bioavailabilitymentioning

confidence: 99%

Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Žiberna

Šamec

Mocan

et al. 2017

IJMS

115

View full text Add to dashboard Cite

show abstract

“…On the other hand, it has been demonstrated that UA has been safely used as a daily dietary supplement, without toxic events [40][41][42]. It is worth remembering that UA is naturally synthesized by different fruits and vegetables present in the human diet [43]; therefore, UA toxicity may be related to the dosage, formulation, duration of treatment and route of administration.…”

Section: Discussionmentioning

confidence: 99%

Preclinical Assessment of Ursolic Acid Loaded into Nanostructured Lipid Carriers in Experimental Visceral Leishmaniasis

et al. 2021

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Ursolic acid, a triterpene produced by plants, displayed leishmanicidal activity in vitro and in vivo; however, the low solubility of this triterpene limits its efficacy. To increase the activity of ursolic acid (UA), this triterpene was entrapped in nanostructured lipid carriers (UA-NLC), physical-chemical parameters were estimated, the toxicity was assayed in healthy golden hamsters, and the efficacy of UA-NLC was studied in experimental visceral leishmanisis. UA-NLC exhibited a spherical shape with a smooth surface with a size of 266 nm. UA-NLC displayed low polydispersity (PDI = 0.18) and good colloidal stability (−29.26 mV). Hamsters treated with UA-NLC did not present morphological changes in visceral organs, and the levels of AST, ALT, urea and creatinine were normal. Animals infected with Leishmania (Leishmania) infantum and treated with UA-NLC showed lower parasitism than the infected controls, animals treated with UA or Amphotericin B (AmB). The therapeutic activity of UA-NLC was associated with the increase in a protective immune response, and it was associated with a high degree of spleen and liver preservation, and the normalization of hepatic and renal functions. These data indicate that the use of lipid nanoparticles as UA carriers can be an interesting strategy for the treatment of leishmaniasis.

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“…can also be used as sources of triterpenes. Dried Vitis vinifera berries have been found to contain up to 79.0 mg/100 g of OA, meanwhile, dried cranberries or blueberries contained both OA and UA (17.8 and 65.5 mg/100 g or 13.9 and 11.8 mg/100 g, respectively) [ 40 ].…”

Section: Chemistry Occurrence and Isolation Of Ursolic And Oleanolic Acidsmentioning

confidence: 99%

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

Gudoityte

Arandarčikaitė

Mažeikienė

et al. 2021

IJMS

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Ursolic and oleanolic acids are secondary plant metabolites that are known to be involved in the plant defence system against water loss and pathogens. Nowadays these triterpenoids are also regarded as potential pharmaceutical compounds and there is mounting experimental data that either purified compounds or triterpenoid-enriched plant extracts exert various beneficial effects, including anti-oxidative, anti-inflammatory and anticancer, on model systems of both human or animal origin. Some of those effects have been linked to the ability of ursolic and oleanolic acids to modulate intracellular antioxidant systems and also inflammation and cell death-related pathways. Therefore, our aim was to review current studies on the distribution of ursolic and oleanolic acids in plants, bioavailability and pharmacokinetic properties of these triterpenoids and their derivatives, and to discuss their neuroprotective effects in vitro and in vivo.

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Oleanolic Acid and Ursolic Acid in Commercial Dried Fruits

Cited by 23 publications

References 14 publications

Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Oleanolic Acid Alters Multiple Cell Signaling Pathways: Implication in Cancer Prevention and Therapy

Preclinical Assessment of Ursolic Acid Loaded into Nanostructured Lipid Carriers in Experimental Visceral Leishmaniasis

Ursolic and Oleanolic Acids: Plant Metabolites with Neuroprotective Potential

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