Olea europaea leaf extract alters microRNA expression in human glioblastoma cells

Tunca, Berrin; Tezcan, Gülçin; Çeçener, Gülşah; Egelí, Ünal; Ak, Seçil; Malyer, Hulusi; Tümen, Gülendam; Bılır, Ayhan

doi:10.1007/s00432-012-1261-8

Cited by 59 publications

(39 citation statements)

References 63 publications

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“…In recent years, oleuropein, used as the main component of a phenolic mixture coming from olive leaves or extra virgin olive oil, has shown antiproliferative effects against some cancer cell lines, such as T98G, Caco-2, and MCF-7 in vitro (10,11,16). Oleuropein also can regress tumors in mice (40).…”

Section: Discussionmentioning

confidence: 99%

“…Indeed, olive phenols such as oleuropein possess several positive functions for human health, including having antioxidant (3), antiinflammatory (4), antimicrobial (5, 6), antiviral (7,8), and neuroprotective activity (9). Additionally, Olea europaea extract inhibits proliferation in a variety of cancer cell lines, such as human colon adenocarcinoma cells Caco-2 (10), human glioblastoma cells T98G (11), melanoma cells B16 (12), human lymphoblastic cell line Jurkat (13), human adenocarcinoma cells HT115 (14), human fetal lung cells MRC-5 (14), and human leukemia cells HL-60 (15). Notably, recent studies have shown that oleuropein inhibits growth and induces apoptosis in human breast cancer cells MCF-7 (16), prostate cancer cell lines LNCaP, DU145 (17) and human lung carcinoma A549 cells (18).…”

Section: Introductionmentioning

confidence: 99%

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Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated With Activation of the c-Jun NH2-Terminal Kinase

Yao

Yang

et al. 2014

J Pharmacol Sci

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Abstract. Oleuropein could inhibit growth and/or induce apoptosis in several cancer cell lines. In this study, we investigate how oleuropein strongly induces apoptotic cell death in HeLa human cervical carcinoma cells. Oleuropein induced HeLa cells apoptosis as demonstrated by induction of a sub-G 1 peak in flow cytometry and apoptosis-related morphological changes observed by fluorescence microscopy after being stained by Hoechst 33324. The results also showed that 150 -200 mM oleuropein-treated HeLa cells were arrested at the G 2 /M phase. Western blot analysis revealed that the phosphorylated ATF-2, c-Jun NH 2 -terminal kinase (JNK) protein, p53, p21, Bax, and cytochrome c protein in the cytoplasm significantly increased in a dose-dependent manner after treatment of oleuropein for 24 h. Additionally, increasing levels of Bax in response to JNK/SPAK signaling, which formed mitochondrial membrane channels, accounted for releasing of cytochrome c and activation of caspase-9 and -3. SP600125 (20 mM), a JNK 1/2 inhibitor, markedly suppressed the formation of apoptotic bodies and JNK activation induced by oleuropein at 200 mM. Thus, oleuropein-induced apoptosis was activated by the JNK/SPAK signal pathway. The result shows that oleuropein holds promise as a potential chemotherapeutic agent for the treatment of HeLa cells.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated With Activation of the c-Jun NH2-Terminal Kinase

Yao

Yang

et al. 2014

J Pharmacol Sci

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“…miRNA target genes are involved in cell cycle and apoptotic pathways. miR-181b, in particular, was markedly overexpressed following treatment with TMZ and OLE (55). Thus, miR-181b may be a potential biomarker for glioma and chemotherapy treatment outcome.…”

Section: Mir-181b In Papillary Thyroid Carcinoma (Ptc)mentioning

confidence: 97%

miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (Review)

Liu

Shi

et al. 2013

Biomedical Reports

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Abstract. MicroRNAs (miRNAs or miRs) are small, non-coding, single-stranded RNA molecules that regulate gene expression at the post-transcriptional level to repress protein expression of target genes. Among these, miR-181b has been found to be a critical regulatory miRNA linking inflammation and cancer. The functional significance of miR-181b in various tumors and translational research suggests that it exhibits great potential as a predictive and prognostic biomarker. Extensive efforts are underway to identify mRNA targets and the affected regulatory networks, which may be the key to providing a better understanding of miR-181b-mediated signaling pathways.

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“…This is a consequence of its high content of oleic acid, which is less susceptible to oxidation than n -6 polyunsaturated fatty acids present in other edible oils (palm, peanut, soybean and sun ﬂower) and for the presence of a high content of antioxidant components (such as hydroxytyrosol and oleuropein), which are potent reactive oxygen species (ROS) scavengers. The beneficial effects of olive oil may in part be attributable to the ability of polyphenolic compounds to induce epigenetic modulation [60] and/or altered miRNA expression [61]. …”

Section: Effects Of Oleuropein On Human Healthmentioning

confidence: 99%

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health

Barbaro¹,

Toietta

Maggio³

et al. 2014

IJMS

238

165

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The use of the products derived from the olive tree on human health dates back centuries. In several civilizations, the olive tree had and still has a very strong cultural and religious symbolism. Notably, the official seal and emblem of the World Health Organization features the rod of Asclepius over a world map surrounded by olive tree branches, chosen as a symbol of peace and health. Recently, accumulating experimental, clinical and epidemiological data have provided support to the traditional beliefs of the beneficial effect provided by olive derivates. In particular, the polyphenols present in olive leaves, olives, virgin (unrefined) olive oil and olive mill waste are potent antioxidant and radical scavengers with anti-tumor and anti-inflammatory properties. Here, we review the positive impact on human health of oleuropein, the most prevalent polyphenol present in olives. In addition, we provide data collected in our laboratory on the role of oleuropein in counteracting lipid accumulation in a mouse model of non-alcoholic fatty liver disease.

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Olea europaea leaf extract alters microRNA expression in human glioblastoma cells

Abstract: Our results suggest that OLE modulates the expression of some miRNAs related to anticancer activity in GBM and the response to TMZ. Further studies and validations are needed, but we suggest that OLE might be used for in vivo studies and future medical drug studies.

Cited by 59 publications

References 63 publications

Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated With Activation of the c-Jun NH2-Terminal Kinase

Oleuropein Induced Apoptosis in HeLa Cells via a Mitochondrial Apoptotic Cascade Associated With Activation of the c-Jun NH2-Terminal Kinase

miR-181b as a key regulator of the oncogenic process and its clinical implications in cancer (Review)

Effects of the Olive-Derived Polyphenol Oleuropein on Human Health

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