Oldest known case of metastasizing prostate carcinoma diagnosed in the skeleton of a 2,700‐year‐old Scythian king from Arzhan (Siberia, Russia)

Schultz, Michael; Parzinger, Hermann; Posdnjakov, Dmitrij V.; Chikisheva, Tatjana A.; Schmidt-Schultz, Tyede H.

doi:10.1002/ijc.23073

Cited by 64 publications

(44 citation statements)

References 21 publications

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“…For example, ancient proteins have revealed past diseases such as osteogenic sarcoma and prostate carcinoma [17,79]. Scott et al [80] reported that osteocalcin analysis is promising for detecting stress.…”

Section: Discussionmentioning

confidence: 99%

Proteomic profiling of archaeological human bone

et al. 2017

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Ancient protein analysis provides clues to human life and diseases from ancient times. Here, we performed shotgun proteomics of human archeological bones for the first time, using rib bones from the Hitotsubashi site (AD 1657–1683) in Tokyo, called Edo in ancient times. The output data obtained were analysed using Gene Ontology and label-free quantification. We detected leucocyte-derived proteins, possibly originating from the bone marrow of the rib. Particularly prevalent and relatively high expression of eosinophil peroxidase suggests the influence of infectious diseases. This scenario is plausible, considering the overcrowding and unhygienic living conditions of the Edo city described in the historical literature. We also observed age-dependent differences in proteome profiles, particularly for proteins involved in developmental processes. Among them, alpha-2-HS-glycoprotein demonstrated a strong negative correlation with age. These results suggest that analysis of ancient proteins could provide a useful indicator of stress, disease, starvation, obesity and other kinds of physiological and pathological information.

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Section: Discussionmentioning

confidence: 99%

Proteomic profiling of archaeological human bone

et al. 2017

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“…Therefore a biomolecular approach to diagnosis in addition to osteological examination can be beneficial [14]. Recently, proteomic profiling of human tumors has provided a better understanding of the molecular pathogenesis of neoplastic diseases and has identified novel biomarkers for early diagnosis.…”

Section: Introductionmentioning

confidence: 99%

Mass Spectrometric Identification of Ancient Proteins as Potential Molecular Biomarkers for a 2000-Year-Old Osteogenic Sarcoma

et al. 2014

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Osteosarcoma is the most common primary malignant tumor of bone usually occurring in young adolescent and children. This disease has a poor prognosis, because of the metastases in the period of tumor progression, which are usually developed previous to the clinical diagnosis. In this paper, a 2000-year-old ancient bone remain with osteogenic sarcoma was analyzed searching for tumor biomarkers which are closely related to this disease. After a specific extraction SDS-PAGE gel electrophoresis followed by tryptic digestion was performed. After the digestion the samples were measured using MALDI TOF/TOF MS. Healthy bone samples from same archaeological site were used as control samples. Our results show that in the pathological skeletal remain several well known tumor biomarkers are detected such as annexin A10, BCL-2-like protein, calgizzarin, rho GTPase-activating protein 7, HSP beta-6 protein, transferrin and vimentin compared to the control samples. The identified protein biomarkers can be useful in the discovery of malignant bone lesions such as osteosarcoma in the very early stage of the disease from paleoanthropological remains.

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“…Strouhal et al, 1996); Russia (e.g. Schultz et al, 2007); Slovakia (e.g. Š efčáková et al, 2001), Italy (e.g.…”

Section: Malignancy In Paleopathological Recordmentioning

confidence: 98%

Metastatic carcinoma in a 14th–19th century skeleton from Constância (Portugal)

Assis

Codinha

2009

Intl J of Osteoarchaeology

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During 2002, the extensive archaeological excavations of the ancient Constâ ncia necropolis (Centre of Portugal), dated from 14th-19th centuries, resulted in the exhumation of 151 individuals. Among the several paleopathological cases, a middle-aged female skeleton with osteolytic lesions in her skull, axial skeleton, upper limbs and femurs was observed. These pathological findings are characterised by an asymmetric pattern with osteolytic focus of distinct size and irregular shape. Some skeletal elements display both osteolytic and osteoblastic lesions. The latter exhibit deposition of fine layers of woven bone. Lesions were observed macroscopically and radiology was used as a complementary method of scrutiny, especially in cases of unclear observation. The case was diagnosed as that of a probable metastatic carcinoma due to the multifocal distribution of the lesions in areas of intense haematopoietic activity, their morphology and some osteoblastic responses, as well as the presence of pathological fractures in the ribs. The skeleton's sex and age at death are in agreement with the proposed diagnostic, constituting the first case of malignant carcinoma detected in non-identified Portuguese human skeletal remains.

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Oldest known case of metastasizing prostate carcinoma diagnosed in the skeleton of a 2,700‐year‐old Scythian king from Arzhan (Siberia, Russia)

Cited by 64 publications

References 21 publications

Proteomic profiling of archaeological human bone

Proteomic profiling of archaeological human bone

Mass Spectrometric Identification of Ancient Proteins as Potential Molecular Biomarkers for a 2000-Year-Old Osteogenic Sarcoma

Metastatic carcinoma in a 14th–19th century skeleton from Constância (Portugal)

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