Older patients (age 65+) report better quality of life, psychological adjustment, and adherence than younger patients 5 years after heart transplant: A multisite study

Shamaskin, Andrea; Rybarczyk, Bruce; Wang, Edward; White‐Williams, Connie; Cotts, William; Grady, Kathleen L.

doi:10.1016/j.healun.2011.11.025

Cited by 46 publications

(32 citation statements)

References 38 publications

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“…[12][13][14][15] However, adverse events and symptoms after MCS are risk factors for poor HRQOL and their increased incidence in older patients may diminish the HRQOL benefits in this population. 16,17 In contrast, we have previously reported that older patients have better short-term 18 and long-term 19 HRQOL outcomes after transplantation as compared with younger patients.…”

mentioning

confidence: 84%

Change in Health-related Quality of Life from Before to After Destination Therapy Mechanical Circulatory Support is Similar for Older and Younger Patients: Analyses from INTERMACS

Grady

Naftel

Myers

et al. 2014

The Journal of Heart and Lung Transplantation

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mentioning

confidence: 84%

Change in Health-related Quality of Life from Before to After Destination Therapy Mechanical Circulatory Support is Similar for Older and Younger Patients: Analyses from INTERMACS

Grady

Naftel

Myers

et al. 2014

The Journal of Heart and Lung Transplantation

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“…12-15 However, adverse events and symptoms after MCS are risk factors for poor HRQOL and their increased incidence in older patients may diminish the HRQOL benefits in this population. 16, 17 In contrast, we have previously reported that older patients have better short-term 18 and long-term 19 HRQOL outcomes after transplantation as compared with younger patients.…”

mentioning

confidence: 88%

Change in health-related quality of life from before to after destination therapy mechanical circulatory support is similar for older and younger patients: Analyses from INTERMACS

Grady¹,

Naftel²,

Myers³

et al. 2015

The Journal of Heart and Lung Transplantation

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Background Destination therapy left ventricular assist devices (DT LVADs) are being increasingly implanted in older adults. Older patients are at increased risk for mortality and morbidity post LVAD, which may impact their health-related quality of life (HRQOL). We sought to examine change in HRQOL by age from before to 1 year after DT LVAD implant and identify factors associated with change. Methods Data were collected from 1,470 continuous flow DT LVAD patients at 108 institutions participating in INTERMACS from January 21, 2010 to March 31, 2012. Patients were divided into three cohorts: <60 years (n=457), 60-69 years (n=520), and ≥70 years (n=493). HRQOL was measured using the generic EQ-5D-3L. Data were collected pre-implant and 3, 6, and 12 months post-implant. Statistical analyses included descriptive statistics, Kaplan-Meier survival analyses, and multivariable regression analyses. Results HRQL improved in all patients. Generally, older patients reported better HRQOL than younger patients pre implant (≥70 yrs, mean=40; 60-69 yrs, mean=33; and < 60 yrs, mean=31, p<0.0001) and 1 year post implant (≥70 yrs, mean=77; 60-69 yrs, mean=72; and < 60 yrs, mean=70, p=0.01) using the EQ-5D visual analog scale (VAS), with 0 = worst imaginable health state and 100 = best imaginable health state. The magnitude of improvement in EQ-5D scores from pre- to 1 year post LVAD was similar in all age groups (≥70 yrs, mean change=33; 60-69 yrs, mean change=35; and < 60 yrs, mean change=35, p=0.77). Factors associated with improvement in HRQOL from before to 1 year after implant were a lower VAS score pre implant and fewer re-hospitalizations after implant (R2=61.3%, p< 0.0001). Conclusions Older patients reported better HRQOL than younger patients before and after LVAD implantation. The magnitude of improvement was similar for all age groups, with more than 70% of all patients evidencing clinically important increases (>10 points on the VAS). Re-hospitalization appears to reduce the magnitude of improvement.

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“…Como queda constatado en varios estudios, el efecto de variables como el género, la edad, la raza y el nivel educativo puede ser incluso contradictorio (Dew et al, 1996a;Shamaskin et al, 2012;Kung et al, 2012). …”

Section: Otros Factores Sociodemográficosunclassified

Evaluación de factores psiquiátricos y psicosociales en una cohorte de receptores de trasplante cardiaco: estudio de seguimiento a 12meses

Sánchez‐González¹

2016

Psiquiatría Biológica

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Older patients (age 65+) report better quality of life, psychological adjustment, and adherence than younger patients 5 years after heart transplant: A multisite study

Cited by 46 publications

References 38 publications

Change in Health-related Quality of Life from Before to After Destination Therapy Mechanical Circulatory Support is Similar for Older and Younger Patients: Analyses from INTERMACS

Change in Health-related Quality of Life from Before to After Destination Therapy Mechanical Circulatory Support is Similar for Older and Younger Patients: Analyses from INTERMACS

Change in health-related quality of life from before to after destination therapy mechanical circulatory support is similar for older and younger patients: Analyses from INTERMACS

Evaluación de factores psiquiátricos y psicosociales en una cohorte de receptores de trasplante cardiaco: estudio de seguimiento a 12meses

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