Older age at first birth is a risk factor for pancreatic cancer: a meta-analysis

Luo, Aijing; Feng, Rui-Hua; Wang, Xiaowan; Wang, Fu-zhi

doi:10.1016/s1499-3872(16)60063-2

Cited by 13 publications

(12 citation statements)

References 34 publications

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“…Meta‐analyses of pancreatic cancer show a risk reduction in parous women compared with nulliparous women , with two children being most protective . Higher risk of pancreatic cancer has been associated with older age at first birth . In contrast, a meta‐analysis demonstrated an increased risk of kidney cancer in parous compared with nulliparous women, and an increase in risk with each subsequent birth .…”

Section: Pregnancy Characteristics and Maternal Cancer Riskmentioning

confidence: 97%

The role of pregnancy, perinatal factors and hormones in maternal cancer risk: a review of the evidence

et al. 2018

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An understanding of the origin of cancer is critical for cancer prevention and treatment. Complex biological mechanisms promote carcinogenesis, and there is increasing evidence that pregnancy‐related exposures influence foetal growth cell division and organ functioning and may have a long‐lasting impact on health and disease susceptibility in the mothers and offspring. Nulliparity is an established risk factor for breast, ovarian, endometrial and possibly pancreatic cancer, whilst the risk of kidney cancer is elevated in parous compared with nulliparous women. For breast, endometrial and ovarian cancer, each pregnancy provides an additional risk reduction. The associations of parity with thyroid and colorectal cancers are uncertain. The timing of reproductive events is also recognized to be important. Older age at first birth is associated with an increased risk of breast cancer, and older age at last birth is associated with a reduced risk of endometrial cancer. The risks of breast and endometrial cancers increase with younger age at menarche and older age at menopause. The mechanisms, and hormone profiles, that underlie alterations in maternal cancer risk are not fully understood and may differ by malignancy. Linking health registries and pooling of data in the Nordic countries have provided opportunities to conduct epidemiologic research of pregnancy exposures and subsequent cancer. We review the maternal risk of several malignancies, including those with a well‐known hormonal aetiology and those with less established relationships. The tendency for women to have fewer pregnancies and at later ages, together with the age‐dependent increase in the incidence of most malignancies, is expected to affect the incidence of pregnancy‐associated cancer.

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Section: Pregnancy Characteristics and Maternal Cancer Riskmentioning

confidence: 97%

The role of pregnancy, perinatal factors and hormones in maternal cancer risk: a review of the evidence

et al. 2018

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“…Pancreatic cancer has a 5-year relative survival rate of 9.2% in Japan, and patients with this cancer have a poor prognosis [1]. It is not known whether chronic pancreatitis is a risk factor for pancreatic cancer [2–4]. Although heavy drinking is an important etiology for chronic pancreatitis, only a small portion of drinkers develop chronic pancreatitis.…”

Section: Introductionmentioning

confidence: 99%

Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup

Fujii

Ohno

Yamada

et al. 2019

Environ Health Prev Med

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BackgroundAlthough fat accumulation in human organs is associated with a variety of diseases, there is little evidence about the effect of a fatty pancreas on the development of subclinical chronic pancreatitis over the clinical course.MethodsWe conducted a prospective cohort study from 2008 to 2014 of patients who underwent a medical checkup consultation for fat accumulated in the pancreas. Patients included in the analysis were divided into a non-fatty pancreas group (n = 9710) and fatty pancreas group (n = 223). The primary end point was the odds ratio (OR) for chronic pancreatitis associated with fatty pancreas, which was diagnosed using ultrasonography. We used a multiple logistic regression model to estimate the OR and the corresponding 95% confidence interval (CI).ResultsNinety-two people were diagnosed with chronic pancreatitis, including both presumptive and definitive diagnoses. Twelve people were diagnosed with chronic pancreatitis by ultrasonography among the 223 patients with fatty pancreas, and 80 patients among 9710 were diagnosed with non-fatty pancreas. The crude OR was 6.85 (95% CI 3.68, 12.75), and the multiple adjusted OR was 3.96 (95% CI 2.04, 7.66).ConclusionsFat accumulation in the pancreas could be a risk factor for developing subclinical chronic pancreatitis.

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“…A few studies but not all found significant associations of pancreatic cancer risk with age at first birth. [29][30][31] Similarly, there is little evidence of an association between pancreatic cancer and hormonal contraception use. 29 Given the conflicting results in the literature, further large studies are needed to clarify the associations of reproductive factors and female hormones use with pancreatic cancer risk.…”

Section: Resultsmentioning

confidence: 99%

Risk of pancreatic cancer in Minia district, Egypt

Abdel-Rehim

Mahfouz

Ewis

et al. 2017

Int J Community Med Public Health

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Background: Pancreatic cancer is considered one of the most lethal malignant neoplasms. Therefore, a better understanding of the etiology and identifying the risk factors are essential for the development of preventive strategies. Methods: This case-control study included pancreatic cancer patients attending Minia Cancer Center during the period from June 2014 to December 2015 and controls from the general population. Several suspected risk factors were evaluated during personal interviews with the study participants. Statistical analysis included crude odds ratio (OR) and multivariable logistic regression with an adjusted OR and 95% confidence interval (CI). Results: The study included 224 subjects, 75 pancreatic cancer cases, and 149 controls. Cases had higher age and male gender than controls. Bivariate analyses showed that age, sex, smoking, family history of pancreatic cancer, physical activity, mental stress, age at first birth, hormonal contraception, diabetes, hepatitis C virus (HCV) infection, pancreatitis, and cholecystitis were associated with pancreatic cancer. In the final multivariable analysis, smoking, physical activity, diabetes, HCV infection, and cholecystitis were significantly associated with pancreatic cancer risk. Conclusions: Pancreatic cancer risk is associated with some potentially modifiable factors like tobacco smoking and low physical activity and related health problems as diabetes, HCV infection, and cholecystitis. Control of known risk factors for pancreatic cancer should be considered to help in risk reduction and prevention.

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Older age at first birth is a risk factor for pancreatic cancer: a meta-analysis

Cited by 13 publications

References 34 publications

The role of pregnancy, perinatal factors and hormones in maternal cancer risk: a review of the evidence

The role of pregnancy, perinatal factors and hormones in maternal cancer risk: a review of the evidence

Impact of fatty pancreas and lifestyle on the development of subclinical chronic pancreatitis in healthy people undergoing a medical checkup

Risk of pancreatic cancer in Minia district, Egypt

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