Abstract:Bone is a dynamic organ in which osteoblasts, under inhibitory control of sclerostin, creates new bone osteoblasts by releasing RANK-L to activate osteoclasts to remove bone. This dynamic network is under local control of miRNAs and long noncoding RNAs to balance the effect of bone stressors on bone formation (1). With aging there is an increase in fragility fractures. Fractures are a more common reason for older persons requiring interaction with medical professionals than any other disease and are one of the… Show more
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