Old and New Causes of Occupational Asthma

Quirce, Santiago; Bernstein, Jonathan A.

doi:10.1016/j.iac.2011.07.001

Cited by 45 publications

(17 citation statements)

References 95 publications

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“…In adult patients with symptoms of rhinoconjunctivitis and asthma, an occupational disease should be ruled out . Only one of review articles on occupational respiratory allergy includes the peach tree as a source of allergens causing occupational respiratory diseases. In our case, symptoms with occupational exposure to peach trees suggested that they could be the cause, and the results of our study support this hypothesis.…”

Section: Discussionmentioning

confidence: 99%

Occupational respiratory allergy in peach crop workers

Pérez-Calderón

Gonzalo-Garijo

Rodríguez-Velasco

et al. 2017

Allergy

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Section: Discussionmentioning

confidence: 99%

Occupational respiratory allergy in peach crop workers

Pérez-Calderón

Gonzalo-Garijo

Rodríguez-Velasco

et al. 2017

Allergy

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“…Obesity is associated with decreased sensitivity to glucocorticoids, a mainstay of asthma treatment (10,75,76). Occupational allergens such as chemicals, dusts, fumes, or other compounds can increase the risk of asthma onset or its exacerbation (77)(78)(79)(80)(81)(82)(83)). An earlier peer review concluded that controlling obesity and occupational exposures are among the best opportunities for asthma prevention (84).…”

Section: Example 13: Obesity Occupational Allergens and Asthmamentioning

confidence: 99%

Conceptual heuristic models of the interrelationships between obesity and the occupational environment

Pandalai¹,

Schulte²,

Miller³

2013

Scand J Work Environ Health

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Pandalai SP, Schulte PA, Miller DB. Conceptual heuristic models of the interrelationships between obesity and the occupational environment. Scand J Work Environ Health. 2013;39(3):221-232. doi:10.5271/sjweh.3363 Objective Research and interventions targeting the relationship between work, its attendant occupational hazards, and obesity are evolving but merit further consideration in the public health arena. In this discussion paper, conceptual heuristic models are described examining the role of obesity as both a risk factor and health outcome in the occupational setting.Methods PubMed was searched using specific criteria from 2000 and onwards for evidence to support conceptual models in which obesity serves as a risk factor for occupational disease or an outcome of occupational exposures. Nine models are presented: four where obesity is a risk factor and five where it is an adverse effect.Results A broad range of work-related health effects are associated with obesity including musculoskeletal disorders, asthma, liver disease, and cardiovascular disease, among others. Obesity can be associated with occupational hazards such as shift work, sedentary work, job stress, and exposure to some chemicals. Conclusion Identification of combinations of risk factors pertinent to obesity in the occupational environmentwill provide important guidance for research and prevention.Key terms cardiovascular disease; diet; endocrine disruptor; intervention study; metabolism; musculoskeletal disease; occupational health; physical activity; risk assessment.1 National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention, Cincinnati, OH, USA.Correspondence to: Sudha P Pandalai, MD, PhD, National Institute for Occupational Safety and Health Centers for Disease Control and Prevention, 4676 Columbia Parkway, Cincinnati, OH 45226, Obesity is increasing worldwide with the 2009-2010 prevalence among US adults surpassing one-third (1, 2). Obesity is associated with genetic, behavioral, occupational, and environmental factors (3-5) and has significant economic impact (6). It is also associated with various health problems including musculoskeletal disorders (MSD), asthma, liver disease, and cardiovascular disease (CVD) (7-10). Moreover, neurohormonal and endocrine pathway disruption has been associated with obesity (11,12). Work factors, including sedentary work and taskrelated biomechanics, have been reported as risks for obesity (13)(14)(15). Variables such as irregular work hours/ sleep schedules, job stress, workplace absenteeism, and reduced productivity also contribute (16)(17)(18)(19).Although the related literature is growing, obesity in the occupational environment requires more study, for example, regarding low-wage workers and genes or other factors (20,21). Body mass index (BMI), a measure of obesity, varies by population, race, gender, and socioeconomic class (22)(23)(24). Genetics may account for ≥40% of the variation in BMI (25), but such estimates can depend on the variability of environ...

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“…This is not surprising, owing to the plethora of environmental factors that can trigger asthma. More than 500 individual triggers have been identified, including allergens [2], viruses [3], bacteria [3], pollutants [4], exercise [5], as well as occupational irritants [6,7] and sensitizers [8].…”

Section: General Statements On Inflammation In Asthmamentioning

confidence: 99%

Airway Hyperresponsiveness in Asthma: A Better Understanding Yet to Yield Clinical Benefit

Bossé¹,

Lee‐Gosselin²,

Boulet³

et al. 2013

J Allergy Ther

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Airway inflammation and hyperresponsiveness (AHR) are important features of asthma. Both inflammation and AHR are complex traits that can each originate from a plethora of factors, where every factor can be independent, interconnected and dispensable. This review examines the complexity of the indices that we use to assess airway responsiveness. These indices entail intricate information regarding the individual and the combined dynamic behavior of all the airways that constitute the tracheobronchial tree during the activation of airway smooth muscle (ASM). Because many factors other than ASM contractility can influence airway narrowing, the defects responsible for the manifestation of AHR are difficult to infer. New tests and technologies are being developed to decipher the meaning of the indices of airway responsiveness and have already leaped forward our understanding of AHR. This review also gives prominence to the concept of ASM plasticity.ASM mass and contractile capacity is not fixed over time. Several facets of inflammation can increase ASM force indirectly over a prolong period of time by causing tissue damage and repair, which ultimately leads of airway wall remodeling that embodies an enlargement of ASM mass. This could contribute to the fixed component of AHR. The gain of force due to inflammation can also be transient and conditional to the presence of inflammatory mediators that are capable of increasing the contractile capacity of ASM. This could contribute to the variable, and more readily modifiable, component of AHR. We are now aware that a multitude of muscle and non-muscle factors can contribute to AHR within an asthmatic individual, and that these factors are often times distinct between individuals. Consequently, the relative contribution of a single factor within a group of patients is usually very small. This is the reason why our ever-growing understanding of AHR in asthma does not quite yet avail patients.

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Old and New Causes of Occupational Asthma

Cited by 45 publications

References 95 publications

Occupational respiratory allergy in peach crop workers

Occupational respiratory allergy in peach crop workers

Conceptual heuristic models of the interrelationships between obesity and the occupational environment

Airway Hyperresponsiveness in Asthma: A Better Understanding Yet to Yield Clinical Benefit

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