Olanzapine treatment after clozapine induced agranulocytosis

Lokshin, Pavel; Dorfman, Pierre; Shoshani, David; Wimmer, Peter; Dossenbach, M.; Belmaker, Robert H.

doi:10.1002/(sici)1099-1077(1998120)13:8<583::aid-hup33>3.0.co;2-e

Cited by 5 publications

(2 citation statements)

References 2 publications

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“…As a matter of fact, it was shown that the antipsychotics CLZ and sulpiride but not haloperidol (another antipsychotics) or OLZ activated brain DNA demethylation at their clinically relevant doses in mice (Dong et al, 2008). On the other hand, Lokshin et al (1999) stated that CLZ and OLZ exhibited similar pharmacological profiles. Although the mechanism of CLZ toxicity is also still not clear, it is reported that the toxicity (agranulocytocis and hepatotoxicity) of CLZ resulted from the accumulation of reactive metabolites of this drug (Lu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

The genotoxic and oxidative damage potential of olanzapine in vitro

Türkez

Toğar

2010

Toxicol Ind Health

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Olanzapine (OLZ) is an atypical antipsychotic drug and is commonly used for the treatment of schizophrenia and bipolar disorder (BD). However, recent reports indicated that this drug could exhibit cytotoxic effects on nervous and immune systems. To our knowledge, there is scarce data considering the genotoxic or oxidative damage potentials of OLZ on human lymphocyte culture system. Therefore, in this study, the genotoxic potential of OLZ (0 to 160 µM) have been evaluated in human whole blood cultures (WBCs) related to oxidative status. Sister-chromatid exchange (SCE) test was applied to estimate the DNA damage, and biochemical parameters (total antioxidant capacity [TAC] and total oxidative stress [TOS]) were examined to determine oxidative stress. Our results indicated that the tested antipsychotic drug did not induce SCEs in lymphocytes of treated cultures. However, the application of the highest OLZ concentration caused oxidative stress. It is concluded that the OLZ can be used safely, but it is necessary to consider the tissue damages that are likely to appear depending on the oxidative stress.

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Section: Discussionmentioning

confidence: 99%

The genotoxic and oxidative damage potential of olanzapine in vitro

Türkez

Toğar

2010

Toxicol Ind Health

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“…As a matter of fact, it was shown that the antipsychotics CLZ and sulpiride but not haloperidol (another antipsychotics, HLP) or OLZ-activated brain DNA demethylation at their clinically relevant doses in mice (Dong et al, 2008). On the other hand, Lokshin et al (1999) indicated that CLZ and OLZ exhibited similar pharmacological profiles. Although the mechanism of CLZ toxicity is also still not clear, it is reported that the toxicity (agranulocytosis and hepatotoxicity) of CLZ resulted from the accumulation of reactive metabolites of this drug (Lu et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

The genotoxic potentials of some atypical antipsychotic drugs on human lymphocytes

et al. 2011

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Olanzapine (OLZ), risperidone (RPD) and quetiapine (QTP) are atypical antipsychotic drugs and are commonly used for the treatments of schizophrenia and bipolar disorders. However, recent reports indicated that these drugs could exhibit toxic effects on nervous and cardiovascular systems. To our best knowledge, there are scarce data considering the genotoxic damage potentials of OLZ, RPD and QTP on human lymphocyte culture system. Therefore, in this study, the genotoxic potentials of OLZ, RPD and QTP (0-400 mg/L) have been evaluated in human whole blood cultures (WBCs; n = 4). The single cell gel electrophoresis (SCGE) and micronucleus (MN) assays were applied to estimate the DNA damage. The results of the present study indicated that the tested antipsychotic drug did not induce genotoxicity. In fact, the mean values of the total scores of cells showing DNA damage (for SCGE assay) and MN/1000 cell were not found significantly different from the control values (p > 0.05). However, the application of the highest drug concentrations (250 mg/L and above) caused the sterility in lymphocyte cultures. It is concluded that the tested three different atypical antipsychotic drugs can be used safely, but it is necessary to consider the cytotoxic effects that are likely to appear depending on the doses exposed.

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