Olanzapine-induced weight gain: Chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution

Zwaal, Esther M. van der; Luijendijk, Mieneke C. M.; Adan, Roger A.H.; Fleur, Susanne E. la

doi:10.1016/j.ejphar.2007.11.078

Cited by 41 publications

(23 citation statements)

References 34 publications

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“…It was found to readily degrade, with a visible colour change in aqueous solutions from yellow to blue [65]. During pharmacokinetic studies using rats, it was found that the acidic olanzapine solutions that were being continuously delivered to the rats were degrading, resulting in a colour change from bright orange to dark green, with formation of an unknown precipitate [66].…”

Section: Anti-psychotic Drugsmentioning

confidence: 99%

The influence of putrefaction and sample storage on post-mortem toxicology results

Butzbach

2009

Forensic Sci Med Pathol

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There are numerous biochemical and biological processes that occur after death that may have a significant influence on post-mortem drug concentrations. These processes may render the quantification of particular drugs unreliable, or even result in drugs being undetectable in some instances, despite the use of several methods. Problems may occur with changes in the drug concentration via bacterial degradation, residual tissue enzymatic activity, or via post-mortem redistribution from tissues of a higher to a lower concentration. Many analytical techniques can suffer from interferences due to co-extracted putrefactive compounds that mask or alter the way a drug is detected, depending on the analytical technique utilised. The following paper reviews problems associated with post-mortem drug concentration changes, and the significance of microbial influences during the post-mortem interval and sample storage.

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Section: Anti-psychotic Drugsmentioning

confidence: 99%

The influence of putrefaction and sample storage on post-mortem toxicology results

Butzbach

2009

Forensic Sci Med Pathol

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“…An alternative method of administration involves an embedded infusion pump, and several studies have reported use of an osmotic pump (Chintoh et al, 2008;Choi et al, 2007;van der Zwaal et al, 2008). However, no study using this implanted osmotic pump has noted antipsychotic-induced metabolic side effects such as weight gain or adiposity in male rats.…”

Section: Introductionmentioning

confidence: 97%

“…One reason for this difficulty is that olanzapine is chemically unstable in acidic solution, which was frequently used to dissolve olanzapine in previous studies. Indeed, plasma concentration of olanzapine was found to decrease to 10% after 4-week infusion with osmotic pump (van der Zwaal et al, 2008).…”

Section: Introductionmentioning

confidence: 99%

Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats

et al. 2011

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“…Pure drug samples of olanzapine (2-methyl-4-(4-methyl-1-piperazinyl)-10H thieno [2,3][1,5]benzodiazepine) and flouxetine were kindly provided by Miracle Pharmaceuticals (Islamabad, Pakistan). HPLC-grade acetonitrile, methanol and ethanol were obtained from Merck (Germany) and used without further purification or filtration.…”

Section: Experimental Materialsmentioning

confidence: 99%

“…Olanzapine has shown to have affinity with dopamine D1 and D2, muscarinic and serotonin 5HT2 receptors [3]. Plasma concentration of olanzapine has a correlation with its clinical effects and also shown to have individual variability in its pharmacokinetics [4,5].…”

Section: Introductionmentioning

confidence: 99%

Development and Validation of Reverse Phase High Performance Chromatography Method for Determination of Olanzapine in Microsample Rat Plasma: Application to Preclinical Pharmacokinetic Study

Pervaiz¹,

Ahmad²,

Minhas³

et al. 2015

Trop. J. Pharm Res

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Purpose: To develop a sensitive and validated reverse phase-high performance liquid chromatographic (RP-HPLC) method for quantification of olanzapine in micro-sample of rat plasma using UV detection. Methods:A single oral dose of olanzapine (7 mg/kg) was given to overnight fasted rats (n = 6). Rat plasma samples containing the drug were extracted by liquid-liquid extraction using a combination of dichloromethane : n-hexane (80:20). A reverse phase chromatographic column C18 hypersil-BDS was used for chromatographic separation with a mobile phase consisting of 50 mM phosphate buffer pH 5.5, acetonitrile and methanol (50:30:20, v/v/v)

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Olanzapine-induced weight gain: Chronic infusion using osmotic minipumps does not result in stable plasma levels due to degradation of olanzapine in solution

Cited by 41 publications

References 34 publications

The influence of putrefaction and sample storage on post-mortem toxicology results

The influence of putrefaction and sample storage on post-mortem toxicology results

Chronic treatment with olanzapine via a novel infusion pump induces adiposity in male rats

Development and Validation of Reverse Phase High Performance Chromatography Method for Determination of Olanzapine in Microsample Rat Plasma: Application to Preclinical Pharmacokinetic Study

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