Olanzapine-induced agranulocytosis

Naumann, Ralph; Felber, Werner; Heilemann, H; Reuster, Thomas

doi:10.1016/s0140-6736(99)03111-6

Cited by 60 publications

(21 citation statements)

References 3 publications

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“…This approach may enable the binding properties of drugs such as olanzapine or quetiapine, related in chemical structure and pharmacological profile to clozapine and recently associated with agranulocytosis, 54,55 and those that are not, to be compared to highlight possible differences in receptor expression. This study found no neurotransmitter receptor that was neutrophil specific.…”

Section: Discussionmentioning

confidence: 99%

Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow

et al. 2003

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The antipsychotic drug clozapine, acts via interaction with selective neurotransmitter receptor systems. Its use however, is associated with lifethreatening agranulocytosis. The mechanism by which this occurs and its possible relationship with the drug's atypicality remain unclear. As a first step in identifying mechanistic pathways involved, profiling of neurotransmitter receptors on human neutrophils, mononuclear and bone marrow stromal cells as putative targets for clozapine-mediated toxicity was undertaken. Expression of mRNA encoding dopaminergic d2, d3, d4; serotonergic 5ht2a, 5ht2c, 5ht3, 5ht6, 5ht7; adrenergic a1a, a2; histaminergic h1 and muscarinic m1, m2, m3, m4, m5 receptors was analyzed by reverse transcription-polymerase chain reaction methods. While 5ht2c, 5ht6, m1 and m2 mRNA were undetected, the presence of the other receptors indicates sites at which clozapine could bind and induce toxicity of neutrophils and stromal components which regulate granulopoiesis. The functional significance of differential receptor expression while unknown, may argue for neural regulation of hematopoiesis.

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Section: Discussionmentioning

confidence: 99%

Potential clozapine target sites on peripheral hematopoietic cells and stromal cells of the bone marrow

et al. 2003

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“…In one of these cases, olanzapine-induced neutropenia occurred 5 days after resolution of previous clozapine-induced neutropenia. 38,39 Furthermore, Meissner and colleagues 40 recently reported two parkinsonian patients who developed reversible leucopenia while being treated with olanzapine, both had a history of clozapineinduced leucopenia.…”

Section: Review Of Safetymentioning

confidence: 99%

Drugs to treat dementia and psychosis

2002

Mov Disord.

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“…However, there are two recent case reports where olanzapine exposure in schizophrenic patients was associated with non-fatal agranulocytosis. In one of these cases, olanzapine-induced neutropenia occurred 5 days after resolution of previous clozapine-induced neutropenia [6,87]. Furthermore, Meissner and colleagues recently reported two parkinsonian patients who developed reversible leucopenia while being treated with olanzapine, both had a history of clozapine-induced leucopenia [81].…”

Section: Olanzapinementioning

confidence: 99%