Oküler Tüberküloz II: Tanı ve Tedavi

Abstract

ÖzetSon dönemlerde tüberkülin deri testi (TDT), interferon gama sal›n›m analizleri (IGRA), toraks›n bilgisayarl› tomografisi ve polimeraz zincir reaksiyonu ile ilgili yap›lm›fl çal›flmalar oküler tüberküloz (TBC) tan›s›n›n konulmas›nda yeni yaklafl›mlar›n do¤mas›na neden olmufltur. Ancak, TDT ve IGRA latent TBC enfeksiyonunun ortaya konmas›nda yard›mc›d›r ve aktif enfeksiyonu ay›rt ettirmez. ‹ntraoküler TBC tan›s›n› destekleyici di¤er bir test ise akci¤erin grafi veya bilgisayarl› tomografi yolu ile görüntülemesidir. Tan› SummaryRecent studies on the clinical importance of tuberculin skin tests (TST), interferon-gamma release assays (IGRAs), chest computed tomography (CT) and polymerase chain reaction have provided a new approach to diagnosing ocular tuberculosis (TBC). However, both TST and IGRAs cannot distinguish between latent TBC infection and active disease. Another corroborative test in the diagnosis of intraocular TBC is the evaluation of the lungs by either chest radiography or CT. Direct evidence for the diagnosis can be obtained by examination of smears and staining for acid-fast organisms, cultures of intraocular tissue/fluid for Mycobacterium tuberculosis, and nucleic acid amplification analysis. In recent years, guidelines have been suggested for the diagnosis of intraocular TBC. The current treatment of intraocular TBC consists of use of four drugs (isoniazid, rifampicin, ethambutol and pyrazinamide) taken for a long period of time (total 9-15 months). (Turk J Ophthalmol 2011; 41: 182-90)

Analysis of the State Archives Republican Archives Documents on Tuberculosis and Fight Against Tuberculosis in the Early Republican Period in Turkiye

“…The concept of tuberculosis control or the fight against tuberculosis is defined as the "war with the tuberculosis" in Turkiye [1].…”

“…Tuberculosis is caused by "mycobacterium tuberculosis" complex bacilli. It is transmitted by airway from a sick person to a healthy person [1]. The microbe "mycobacterium bovis" in cattle can be transmitted from animals to humans through breathing and unpasteurised milk [2].…”

“…However, it is actually a dangerous disease that can involve all organs and systems. Symptoms may include physical examination, microbiology and radiological findings [1].…”

“…With effective treatment, the number of bacilli and cough frequency decrease rapidly within days. The infectiousness of patients practically ends in two to three weeks with effective treatment [1].…”

“…In the same year, germ strains were brought to Turkiye and new units for vaccine production were constructed at the "Central Institute of Hygine" in Ankara [7]. In 1932, the first "Guide for the Fight Against Tuberculosis" was published [1].…”