Okuläre Symptomatik und Leukämie im Kindesalter

Krebs, Wolf; Metz, O; Plenert, W

doi:10.1055/s-2008-1055260

Cited by 5 publications

(1 citation statement)

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“…Retinal hemorrhages, pre- and subretinal hemorrhages, cotton wool spots, optic disc edema, and invasion of neoplastic cells, among others, are some of the various ocular complications that have been reported for leukemia over the years [ 1 ]. However, bilateral massive vitreous hemorrhages are extremely rare [ 2 , 3 , 4 , 5 , 6 ]. Tanji et al [ 7 ] have reported adult cases with vitreous hemorrhages that were related to leukemia.…”

Section: Discussionmentioning

confidence: 99%

A Case of Childhood Vitrectomy Performed for Dense Vitreous Hemorrhage Secondary to Leukemia Therapy and Tumor Lysis Syndrome

Kudo

Suzuki

Metoki

et al. 2015

Case Rep Ophthalmol

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Purpose: To report a case of vitrectomy performed in a child with dense massive vitreous hemorrhage due to secondary acute myelogenous leukemia (AML) and tumor lysis syndrome. Case: A 4-year-old boy with clear-cell renal cell carcinoma was successfully treated with chemotherapy in 2011. However, in May 2012, he developed secondary AML. Although he was treated with combined chemotherapy and radiation, tumor lysis syndrome occurred with renal and heart failure complications. After an ultrasound examination by pediatricians found bilateral subretinal protrusions, he was referred to our clinic. Fundus examinations confirmed that the protrusions were bilateral subretinal or choroidal hemorrhages. A few weeks later, dense vitreous hemorrhages occurred bilaterally, and he completely lost vision in both eyes. Electroretinograms were extinguished in both eyes. After improvement of his general condition, we performed a 25-gauge vitrectomy combined with lens extraction in his left eye in December 2012. After removal of the vitreous hemorrhage, we found the subretinal hemorrhage had already been absorbed, leaving a mottled fundus color. However, the optic disc was not pale. Nine months after the surgery, his best-corrected visual acuity finally improved to 0.1. Conclusion: We successfully treated a case of severe vitreous hemorrhage secondary to leukemia therapy and tumor lysis syndrome using 25-gauge vitrectomy. This procedure may be safe and effective to perform, even in children with complications.

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Section: Discussionmentioning

confidence: 99%

A Case of Childhood Vitrectomy Performed for Dense Vitreous Hemorrhage Secondary to Leukemia Therapy and Tumor Lysis Syndrome

Kudo

Suzuki

Metoki

et al. 2015

Case Rep Ophthalmol

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Leukemic iris infiltration as the only site of relapse in a child with acute lymphoblastic leukemia: Temporary remission with high‐dose chemotherapy

Behrendt

Wenniger-Prick

1985

Med. Pediatr. Oncol.

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A 12-year-old Caucasian boy developed leukemic hyphema with iris infiltration as the only relapse site during the third complete remission of his acute lymphoblastic leukemia. With high-dose methotrexate, high-dose cytosine-arabinoside plus teniposide, and a 5-week course of vincristine, prednisolone, and L-asparaginase, a complete remission could be achieved. Maintenance treatment was reinstituted for 1 year. However, after stopping the treatment, the iris infiltrate reappeared, and this time the eye was irradiated after chemotherapeutic reinduction. Seven months later, the boy remains in complete remission. The pathogenesis of leukemic iris infiltration is discussed briefly.

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The Eye and Systemic Disease

Ruprecht¹,

Naumann²

1986

Pathology of the Eye

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Okuläre Symptomatik und Leukämie im Kindesalter

Cited by 5 publications

References 0 publications

A Case of Childhood Vitrectomy Performed for Dense Vitreous Hemorrhage Secondary to Leukemia Therapy and Tumor Lysis Syndrome

A Case of Childhood Vitrectomy Performed for Dense Vitreous Hemorrhage Secondary to Leukemia Therapy and Tumor Lysis Syndrome

Leukemic iris infiltration as the only site of relapse in a child with acute lymphoblastic leukemia: Temporary remission with high‐dose chemotherapy

The Eye and Systemic Disease

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