Okra polysaccharides can reverse the metabolic disorder induced by high-fat diet and cognitive function injury in Aβ1–42 mice

Yan, Tingxu; Nian, Tingting; Wu, Bo; Xiao, Feng; He, Bin; Bi, Kaishun; Jia, Ying

doi:10.1016/j.exger.2019.110802

Cited by 15 publications

(9 citation statements)

References 36 publications

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“…We found that okra treatment in pre-diabetic and T2D patients has beneficial effects on glycaemic control, as demonstrated by a significant reduction in the level of FBG. These findings are consistent with the results reported by previous researchers ( Khatun et al, 2011 ; Majd et al, 2018 ; Nguekouo et al, 2018 ; Husen et al, 2020 ; Uadia et al, 2020 ; Wu et al, 2020 ; Yan et al, 2020 ; Tyagita et al, 2021 ; Haque et al, 2022 ). One of the proposed mechanisms that okra targets in reducing FBG is the stimulation of hepatic glycogen synthesis and pancreatic islet regeneration, thus leading to increased insulin secretion and subsequent delay in the intestinal absorption of glucose.…”

Section: Discussionsupporting

confidence: 93%

Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

et al. 2023

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Background: Despite the use of available pharmaceutical drugs, high rates of metabolic diseases and cardiovascular disorders are alarming. This calls for alternative therapies that can attenuate these complications. Therefore, we investigated the beneficial effects of okra on glycaemic control in pre-diabetes and type 2 diabetes mellitus (T2D).Methods: MEDLINE and Scopus were searched for relevant studies. Collected data were analysed using RevMan and reported as mean difference and 95% confidence intervals (CI). Eight studies, including 331 patients with pre-diabetes or T2D, were eligible.Results: Our findings showed that okra treatment reduced the levels of fasting blood glucose: mean difference (MD) = −14.63 mg/dL; 95% CI (-25.25, −4.00, p = 0.007); I2 = 33%, p = 0.17 compared to placebo. Glycated haemoglobin, however, did not differ significantly between the groups: MD = 0.01%; 95%CI (-0.51, 0.54, p = 0.96); I2 = 23%, p = 0.28.Conclusion: this systematic review and meta-analysis found that okra treatment improves glycaemic control in patients with pre-diabetes or T2D. The findings suggest that okra may be used as a supplemental dietary nutrient, especially in pre-diabetic and T2D patients due to its potential to regulate hyperglycaemia.

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Section: Discussionsupporting

confidence: 93%

Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

et al. 2023

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“…Several health beneficial effects are observed via okra polysaccharides treatment such as antidiabetes, antidepression, antifatigue, and cognitive function improvement (Li, Deng, et al, 2020; Liao et al, 2019; Yan, Nian, Liao, et al, 2020; Yan, Nian, Wu, et al, 2020), but the role of RNP and OP for colitis prevention and treatment is still unclear. Some studies used 50, 100, and 200 mg/kg b.w., or even 300 mg/kg b.w.…”

Section: Discussionmentioning

confidence: 99%

Rhinacanthus nasutus and okara polysaccharides attenuate colitis via inhibiting inflammation and modulating the gut microbiota

Chen

Shen

Lin

et al. 2022

Phytotherapy Research

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Plant polysaccharides have prebiotic properties for gut microbiota and immune modulation. This study aimed to investigate the prevention abilities of edible Rhinacanthus nasutus polysaccharide (RNP) and okara polysaccharide (OP) in Sprague-Dawley rats with acetic acid-induced colitis. The characterizations of RNP and OP were analyzed, including Fourier transform infrared, thermogravimetric analysis, differential scanning calorimetry, and monosaccharide composition. The prebiotic properties of RNP and OP were determined in vitro. In addition, the pathological features of colon length and inflammatory cytokine levels in acetic acid-induced colitis were improved by intragastric preadministration of RNP and OP for 3 weeks. There was no nephrotoxicity or hepatotoxicity in rats via histopathological assessment after RNP and OP intake. Moreover, the abundance of short-chain fatty acids-producing bacteria (Lachnospiraceae, Lactobacilli, and Prevotellaceae) were increased after RNP supplementation. In conclusion, intragastric gavage of RNP and OP significantly modulated the gut microbiota and immune response, consequently alleviating the symptoms of colitis. This novel finding provides an alternative strategy and potential application of these two polysaccharides for colitis prevention and treatment.

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“…Previous works have reported an okra-induced significant improvement in the retrieval of long-term reference memory in dexamethasone-induced [ 36 ] and Aβ 1–42 /HFD-induced spatial memory impairment in MWM [ 22 ]. Okra polysaccharide (consisting of mannose, rhamnose, glucose, galactose, and Arabia sugar) inhibited shrinkage of nuclei, neuron rarefaction in the CA1 region of the hippocampus, and increased the downregulated PI3K, Akt, and pERK1/2 in the hippocampus of obese Alzheimer’s disease (AD) mice [ 42 ]. In dexamethasone-treated (60 mg/kg/d for 21 days) mice, pre-treatment with okra extract (60 mg/kg; consisting of catechin, epicatechin, procyanidin B1, and B2, quercetin and rutin), quercetin (60 mg/kg; alone), and rutine (60 mg/kg; alone) restored NR2A/B protein levels, BrdU-immunoreactivity (neurogenesis), and neuronal damage in NMDAR+ cells in the hippocampus [ 36 ].…”

Section: Discussionmentioning

confidence: 99%

“…In dexamethasone-treated (60 mg/kg/d for 21 days) mice, pre-treatment with okra extract (60 mg/kg; consisting of catechin, epicatechin, procyanidin B1, and B2, quercetin and rutin), quercetin (60 mg/kg; alone), and rutine (60 mg/kg; alone) restored NR2A/B protein levels, BrdU-immunoreactivity (neurogenesis), and neuronal damage in NMDAR+ cells in the hippocampus [ 36 ]. Okra polysaccharide, which consists of rhamnose, arabinose, galactose, glucuronic acid, and galactosyl acid, also reduced pro-inflammatory markers, including mRNA expressions of TLR4, NF-κB p65 and IKKα, and protein expressions of TNFα, IL-6, and IL-1β in the chronic stress-induced mice hippocampus, and upregulated ERK1/2, JNK, and p38 (MAPK signaling) in Bv-2 microglia cells [ 42 ]. Furthermore, aqueous extract of okra seed, which mainly consists of catechin and quertin derivatives, reduced MDA, and increased antioxidant activities, and elevated neurotransmitter levels such as dopamine, norepinephrine, acetylcholine, serotonin, and epinephrine in the hippocampus of depressed mice [ 43 ].…”

Section: Discussionmentioning

confidence: 99%

“…Okra polysaccharide [ 40 ] and seeds [ 41 ] alleviate depression- and anxiety-like behaviors in mice through its antioxidant and anti-inflammatory activities. Okra polysaccharide also improved HFD-induced cognitive deficits in Aβ 1–42 obese mice in novel object recognition and MWM tasks [ 42 ] In line with these evidences, the present study was undertaken to investigate the potential ameliorative effects of okra peel in chronic HFD-induced cognitive detriments in C57BL/6J mice using an MWM task.…”

Section: Introductionmentioning

confidence: 96%

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Abelmoschus Esculentus (L.) Moench’s Peel Powder Improves High-Fat-Diet-Induced Cognitive Impairment in C57BL/6J Mice

Prom-in

Kaewsrichan

Wangpradit

et al. 2020

IJERPH

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Okra peel exhibits numerous therapeutic effects. This study explores the potential ameliorative effects of okra peel powder on high-fat-diet (HFD)-induced hypercholesterolemia and cognitive deficits. Thirty-six C57BL/6J male mice were randomly divided into six groups (n = 6 per group): (i) control, mice fed with a normal diet; (ii) HFD, mice fed with HFD; (iii) HFD-SIM, mice fed with HFD and given simvastatin (20 mg/kg/day); (iv) HFD-OP1; (v) HFD-OP2; (vi) HFD-OP3, mice fed with HFD and okra peel (200, 400, or 800 mg/kg/day, respectively). Following 10 weeks of treatments, the mice were subjected to the Morris water maze (MWM). Parameters such as weekly average body weight, food intake, and blood lipid profiles were also recorded. The HFD group showed a profound increase in total cholesterol and low-density lipoprotein concentration compared to the control group. All okra-treated and HFD-SIM groups performed better than the HFD group during acquisition trials, whereas only the HFD-OP1 produced a significantly higher number of entries into the platform zone during the probe trial. In sum, all three okra doses improved the learning ability of the mice. However, only the lowest dose of okra significantly improved the spatial reference memory retention.

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Okra polysaccharides can reverse the metabolic disorder induced by high-fat diet and cognitive function injury in Aβ1–42 mice

Cited by 15 publications

References 36 publications

Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

Okra ameliorates hyperglycaemia in pre-diabetic and type 2 diabetic patients: A systematic review and meta-analysis of the clinical evidence

Rhinacanthus nasutus and okara polysaccharides attenuate colitis via inhibiting inflammation and modulating the gut microbiota

Abelmoschus Esculentus (L.) Moench’s Peel Powder Improves High-Fat-Diet-Induced Cognitive Impairment in C57BL/6J Mice

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