OK‐432 Therapy for Cervical Lymphangioma

Sichel, Jean‐Yves; Udassin, Raphael; Gozal, David; Koplewitz, Benjamin Z.; Dano, Itszhak; Eliashar, Ron

doi:10.1097/00005537-200410000-00024

Cited by 72 publications

(65 citation statements)

References 16 publications

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“…Previous reports have stated that surgical 86 Motz et al, OK432 Versus Doxycycline for Lymphatic Malformations excision is not more complicated after OK432 sclerotherapy. 2,3,[22][23][24]27,28 We found this to be true in the excision of an organized hematoma.…”

mentioning

confidence: 67%

OK432 Versus Doxycycline for Treatment of Macrocystic Lymphatic Malformations

Motz

Nickley

Bedwell

et al. 2014

Ann Otol Rhinol Laryngol

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Objectives: A variety of sclerotherapy agents are used to treat macrocystic lymphatic malformations (LMs). This retrospective study at a single institution was performed to compare the outcomes of pediatric macrocystic LMs of the head and neck that were treated with doxycycline or with OK432. Methods:The outcomes measured included early response to therapy, number of treatments required, operating room time, and adverse events. Results:The rates of clinical success for OK432 and doxycycline were similar (83% and 82%, respectively; p > 0.05), although OK432-treated patients required more treatments than did doxycycline-treated patients (1.9 versus 1.0 injections; p = 0.01; 95% confidence interval, 1.57 to 0.27). The average operating room time for a single OK432 injection was significantly shorter than that for doxycycline (53.2 versus 98.1 minutes; p < 0.001); however, when the total number of treatments administered was considered, the overall times in the operating room were similar. Adverse events in the early postoperative period were more common in OK432-treated patients, who experienced marked postoperative swelling compared to doxycycline-treated patients.Conclusions: OK432 and doxycycline are both effective sclerosants for the treatment of predominantly macrocystic LMs. The administration time for OK432 is shorter than that for doxycycline, but OK432 required more treatments overall to achieve clinical success. Early adverse events were more common in OK432-treated patients, but longer follow-up is necessary to determine whether rates of recurrence and adverse events are similar, particularly in light of the risk of tooth discoloration in doxycycline-treated patients.

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confidence: 67%

OK432 Versus Doxycycline for Treatment of Macrocystic Lymphatic Malformations

Motz

Nickley

Bedwell

et al. 2014

Ann Otol Rhinol Laryngol

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“…[12][13][14][15] However, several authors have suggested that sclerotherapy may be a more appropriate first-line therapy. 16,17 Although sclerotherapy is now well established in the treatment of neonatal and paediatric cystic hygromas, there have been relatively few cases reported of its use in adult patients. Some success has been reported in small numbers of adults with sclerotherapy agents such as OK-432.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of management of lymphangiomas in a tertiary care hospital: a prospective, open label, clinical study

Chahal

Tiwari

2016

Int Surg J

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“…[11] The centripetal theory discusses aberrant congenital lymphatic development. [12] The end result for both theories is the inability of the peripheral lymphatics to drain into the jugular sacs. In adults, lymphangiomas may occur from delayed proliferation of cell rests, either spontaneously or in response to infection or trauma.…”

Section: Discussionmentioning

confidence: 99%