OK-432 pleurodesis for the treatment of pneumothorax in patients with interstitial pneumonia

Ogawa, Kazumasa; Takahashi, Yasuhiro; Murase, Kyoko; Hanada, Shigeo; Uruga, Hironori; Takaya, Hisashi; Miyamoto, Atsushi; Morokawa, Nasa; Kurosaki, Atsuko; Kishi, Kazuma

doi:10.1016/j.resinv.2018.05.003

Cited by 16 publications

(21 citation statements)

References 22 publications

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“…16 There are also reports on acute respiratory distress syndrome after talc or OK-432 administration. 14,15 Moreover, another study showed that pleurodesis could induce acute A, Difference in the decline in the vital capacity (VC) between patients who used talc and those who did not use talc. Among patients who underwent pleurodesis, the decline in VC at 6 months postoperatively in patients who used talc and those who did not use talc were À12.9% AE 4.2% and À22.2% AE 2.8%, respectively (P ¼ .076).…”

Section: Discussionmentioning

confidence: 99%

Impact of postoperative pleurodesis on pulmonary function after lung segmentectomy

et al. 2021

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Objective: Pleurodesis is among several treatment strategies for postoperative alveolo-pleural fistula (APF) after lung resection. Accordingly, the present study aimed to determine the influence of pleurodesis on postoperative pulmonary function.Methods: Patients who underwent anatomical segmentectomy between January 2009 and March 2020 and pulmonary function tests 6 and 12 months after initial surgery were included in this study. Differences in pulmonary function decline between patients who did and did not undergo pleurodesis were compared.Results: Among the 319 patients included, 39 (12.2%) underwent pleurodesis. Among patients who did not receive pleurodesis, there were no difference in decline of vital capacity at 6 months (À13.7% AE 1.1% vs À11.2% AE 0.7%; P ¼ .063) and 12 months (À10.7% AE 1.3% vs À9.5% AE 0.7%; P ¼ .391) after surgery between patients who had APF on postoperative day 2 and those who did not. Patients who received pleurodesis had a significantly larger decline in vital capacity at 6 months (À19.4% AE 2.4% vs À13.7% AE 1.1%; P ¼ .015) and 12 months (À16.2% AE 1.6% vs À10.7% AE 1.3%; P ¼ .010) after surgery compared with those who had APF on postoperative day 2 and did not receive pleurodesis. There were no significant differences in decline of forced expiratory volume in 1 second.

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Section: Discussionmentioning

confidence: 99%

Impact of postoperative pleurodesis on pulmonary function after lung segmentectomy

et al. 2021

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“…OK-432 is used effectively in the literature to reduce prolonged air leakage. 19,20) However, the health insurance system in our country does not provide OK-432; for this reason, we use blood pleurodesis for PAL. Dogru et al 7) reported that smaller cysts regressed with albendazole therapy, and stated that small-diameter cysts can be managed with medical treatment.…”

Section: Discussionmentioning

confidence: 99%

Evaluating Giant Hydatid Cysts: Factors Affecting Mortality and Morbidity

Doğru

Sezen

Aker

et al. 2021

ATCS

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Hydatid disease most frequently affects the liver (50-60%, followed by the lung (18-35%). It is an endemic parasitosis common in developing countries. 1) Hydatid cysts are typically considered giant when they reach 10 cm in diameter or larger. Giant cysts are particularly difficult to treat. 2-4) There are a limited number of studies on giant cysts in the literature. 1,4-6) The aim of this study was to evaluate the prognostic factors affecting morbidity and mortality and the incidence of recurrence among patients who underwent surgery for giant pulmonary hydatid cysts in our center. Materials and Methods Patients who underwent operations in our center due to pulmonary hydatid cyst between 2008 and 2018 were evaluated retrospectively. Patients with missing data or irregular follow-up were excluded from the study. A total Objective: The aim of this study was to evaluate the prognostic factors affecting morbidity and mortality among patients who underwent surgery for giant pulmonary hydatid cysts in our center. Methods: Data from 283 patients who underwent surgery in our center for pulmonary hydatid cyst between 2008 and 2018 were retrospectively analyzed. Cysts 10 cm in diameter or larger were considered giant hydatid cysts. Results: There were 145 women (51.2%) and 138 men (48.8%). Giant cyst (≥10 cm) was present in 57 patients (20.1%), while the other 226 patients (79.9%) had cysts smaller than 10 cm. Operations were performed using videothoracoscopic approach in 68 patients (24%) and with thoracotomy in 215 patients (76%). Hydatid cysts were on the left side in 129 patients (45.6%), on the right side in 143 patients (50.5%), and bilateral in 11 patients (3.9%). Postoperative morbidity occurred in 29 patients (10.2%). Use of videothoracoscopic surgical approach did not affect morbidity. The mortality rate within the first 90 days was 0.35% (n = 1). Conclusion: Giant cysts are more common in the young age group than in older adults. Regardless of cyst size, surgery should be performed as soon as possible after diagnosis to avoid potential complications.

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“…One of the most important issues in the treatment of PSP is preventing recurrence. Although surgery is the most effective treatment for PSP, the recurrence rate of pneumothorax remains 5-15% after thoracoscopic surgery [3][4][5][6]11,12 . In order to minimize recurrence rate of postoperative pneumothorax, chemical pleurodesis has been performed simultaneously with resection or sequentially.…”

Section: Discussionmentioning

confidence: 99%

“…Bullectomy should be considered in patients with recurrent pneumothorax. However, postoperative recurrence still occurs after bullectomy with rates ranging from 6 to 14% [3][4][5][6] . Thus, several additional procedures including the use of brin sealants, radiofrequency therapy, and simultaneous pleurectomy or pleurodesis with bullectomy have been described to minimize the recurrence of PSP 5,[7][8][9][10] .…”

Section: Introductionmentioning

confidence: 99%

Simultaneous Viscum Pleurodesis and Bullectomy in Patients With Primary Spontaneous Pneumothorax

Jung

Kim

2021

Preprint

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Objectives: Although surgery is the gold standard for treatment of primary spontaneous pneumothorax (PSP), recurrence after surgery remains a concern. This study sought to evaluate the efficacy of simultaneous pleurodesis using Viscum album (VA) extract and bullectomy for the treatment of PSP.Methods: From March 2016 to November 2020, 196 patients with PSP underwent bullectomy and intraoperative pleurodesis with VA extract at a single institution. All operations were performed through video-assisted thoracic surgery by one surgeon. Upon completion of bullectomy, a polyglycolic acid sheet was used to cover the stapler lines, and 40 mg of VA extract was instilled over the entire chest wall before chest tube placement.Results: The mean operating time was 18.5±5.0 minutes (range, 10–65) and the mean indwelling time of chest drainage was 1.8±0.5 days (range, 2–6). There were no postoperative complications over grade 3. During the median follow-up period of 36.3±18.4 months (range, 2–57), no recurrence of pneumothorax was observed.Conclusions: The results of this study demonstrated that simultaneous Viscum pleurodesis and bullectomy provides a feasible and effective treatment option for preventing postoperative pneumothorax in patients with PSP.

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OK-432 pleurodesis for the treatment of pneumothorax in patients with interstitial pneumonia

Cited by 16 publications

References 22 publications

Impact of postoperative pleurodesis on pulmonary function after lung segmentectomy

Impact of postoperative pleurodesis on pulmonary function after lung segmentectomy

Evaluating Giant Hydatid Cysts: Factors Affecting Mortality and Morbidity

Simultaneous Viscum Pleurodesis and Bullectomy in Patients With Primary Spontaneous Pneumothorax

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