OIP5-AS1 contributes to tumorigenesis in hepatocellular carcinoma by miR-300/YY1-activated WNT pathway

Wang, Yu; Dou, Liping; Qin, Yun; Yang, Huohai; Peng, Yan

doi:10.1186/s12935-020-01467-6

Cited by 10 publications

(7 citation statements)

References 54 publications

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“…MiR-300/FA2H affects gastric cancer cell proliferation and apoptosis. The OIP5-AS1/miR-300/YY1 feedback loop facilitates cell growth in HCC by activating the WNT pathway [ 45 , 46 ]. MiR-15a-3p may contribute to adenoma-to-carcinoma progression.…”

Section: Discussionmentioning

confidence: 99%

The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer

Song

Zhong

et al. 2021

BMC Med Genomics

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Background The present study aimed to identify a specific circular RNA (circRNA) for early diagnosis of gastric cancer (GC). Methods Totally 82 patients with GC, 30 with chronic nonatrophic gastritis and 30 with chronic atrophic gastritis were included in this study. Four of the 82 GC patients were selected for screening. Total RNA from malignant and adjacent tissue samples was extracted, and circRNAs in four patients were screened. According to the screening results, the eight most upregulated and downregulated circRNAs with a statistically significant association with GC were identified by real-time fluorescent quantitative polymerase chain reaction (PCR). Then, the most regulated circRNA was selected for further sensitivity and specificity assessments. CircRNA expression was examined by quantitative reverse transcriptase PCR in 78 GC (21 and 57 early and advanced GC, respectively) and adjacent tissue samples, as well as in gastric fluid samples from 30 patients with chronic nonatrophic gastritis, 30 with chronic atrophic gastritis, and 78 GC. Results A total of 445 circRNAs, including 69 upregulated and 376 downregulated circRNAs, showed significantly altered expression in GC tissue samples. Hsa_circ_000780 was significantly downregulated in 80.77% of GC tissue samples, with levels in GC tissue samples correlating with tumor size, tumor stage, T stage, venous invasion, carcinoembryonic antigen amounts, and carbohydrate antigen 19–9 levels. Strikingly, this circRNA was found in the gastric fluid of patients with early and advanced GC. Conclusions The present study uncovered a new circRNA expression profile in human GC, with hsa_circ_000780 significantly downregulated in GC tissue and gastric fluid specimens. These findings indicate that hsa_circ_000780 should be considered a novel biomarker for early GC screening.

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Section: Discussionmentioning

confidence: 99%

The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer

Song

Zhong

et al. 2021

BMC Med Genomics

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“…MiR-300/FA2H affects gastric cancer cell proliferation and apoptosis. The OIP5-AS1/miR-300/YY1 feedback loop facilitates cell growth in HCC by activating the WNT pathway [46,47]. MiR-15a-3p may contribute to adenoma-to-carcinoma progression.…”

Section: Discussionmentioning

confidence: 99%

The Circular RNA hsa_circ_000780 as a Potential Molecular Diagnostic Target for Gastric Cancer

Song

Zhong

et al. 2021

Preprint

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Background: The present study aimed to identify a specific circular RNA (circRNA) for early diagnosis of gastric cancer (GC).Methods: Totally 82 patients with GC, 30 with chronic nonatrophic gastritis and 30 with chronic atrophic gastritis were included in this study. Four of the 82 GC patients were selected for screening. Total RNA from malignant and adjacent tissue samples was extracted, and circRNAs in four patients were screened. According to the screening results, the eight most upregulated and downregulated circRNAs with a statistically significant association with GC were identified by real-time fluorescent quantitative polymerase chain reaction (PCR). Then, the most regulated circRNA was selected for further sensitivity and specificity assessments. CircRNA expression was examined by quantitative reverse transcriptase PCR in 78 GC and adjacent tissue samples, as well as in gastric fluid samples from 30 patients with chronic nonatrophic gastritis, 30 with chronic atrophic gastritis, 21 with early GC, and 57 with advanced GC.Results: A total of 445 circRNAs, including 69 upregulated and 376 downregulated circRNAs, showed significantly altered expression in GC tissue samples. Hsa_circ_000780 was significantly downregulated in 80.77% of GC tissue samples, with levels in GC tissue samples correlating with tumor size, tumor stage, T stage, venous invasion, carcinoembryonic antigen amounts, and carbohydrate antigen 19-9 levels. Strikingly, this circRNA was found in the gastric fluid of patients with early and advanced GC.Conclusions: The present study uncovered a new circRNA expression profile in human GC, with hsa_circ_000780 significantly downregulated in GC tissue and gastric fluid specimens. These findings indicate that hsa_circ_000780 should be considered a novel biomarker for early GC screening.

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“…Disruption of cell cycle progression is an established hallmark of cancer, which may result in uncontrolled cellular proliferation [ 111 ]. Phosphorylation of β-catenin is able to trigger cyclin production, which links the Wnt signaling to cell cycle regulation [ 110 , 112 ]. Given the pivotal role of Wnt/β-catenin in osteosarcoma cell cycle modulation, some studies have sought to identify the corresponding associated lncRNAs.…”

Section: Regulatory Network Of Lncrnas and Wnt Signaling Pathway In Osteosarcomamentioning

confidence: 99%

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

Lin

Liu

et al. 2021

Cancer Cell Int

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Osteosarcoma is a common and highly malignant bone tumor among children, adolescents and young adults. However, the underlying molecular mechanisms remain largely unexplored. LncRNAs are transcripts with no or limited protein-coding capacity in human genomes, and have been demonstrated to play crucial functions in initiation, progression, therapeutic resistance, recurrence and metastasis of tumor. Considerable studies revealed a dysregulated lncRNA expression pattern in osteosarcoma, which may act as oncogenes or suppressors to regulate osteosarcoma progression. Wnt signaling pathway is an important cascade in tumorigenesis by modulation of pleiotropic biological functions including cell proliferation, apoptosis, differentiation, stemness, genetic stability and chemoresistance. Hyperactivation or deficiency of key effectors in Wnt cascade is a common event in many osteosarcoma patients. Recently, increasing evidences have suggested that lncRNAs could interplay with component of Wnt pathway, and thereby contribute to osteosarcoma onset, progression and dissemination. In this review, we briefly summarize Wnt signaling-related lncRNAs in osteosarcoma progression, aiming to gain insights into their underlying crosstalk as well as clinical application in osteosarcoma therapeutic modalities.

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OIP5-AS1 contributes to tumorigenesis in hepatocellular carcinoma by miR-300/YY1-activated WNT pathway

Cited by 10 publications

References 54 publications

The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer

The circular RNA hsa_circ_000780 as a potential molecular diagnostic target for gastric cancer

The Circular RNA hsa_circ_000780 as a Potential Molecular Diagnostic Target for Gastric Cancer

Functional interplay between long non-coding RNAs and the Wnt signaling cascade in osteosarcoma

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