Oily nanosuspension for long-acting intramuscular delivery of curcumin didecanoate prodrug: Preparation, characterization and in vivo evaluation

Wei, Xiao-Lan; Han, Ying-Rui; Quan, Li-Hui; Liu, Chunyu; Liao, Yong-Hong

doi:10.1016/j.ejps.2013.03.010

Cited by 41 publications

(17 citation statements)

References 21 publications

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“…In order to solve this problem, reducing the particle sizes to nanoscale by wet milling is often used. Wet milling is considered to be one of the best approaches to prepare nanocrystals for large-scale production [7]. The mixed coarse suspension of drug and stabilizers are fed into the grinding jar with grinding media.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo

Hu¹,

Kong²,

Hu³

et al. 2016

Nano Online

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This paper focused on formulating high-performance curcumin spray-dried powders for inhalation (curcumin-DPIs) to achieve a high lung concentration. Curcumin-DPIs were produced using wet milling combined with the spray drying method. The effects of different milling times on particle size and aerodynamic performance were investigated. The curcumin-DPIs were characterized by scanning electron microscopy (SEM), differential scanning calorimetry (DSC), powder X-ray diffraction (PXRD), Fourier transform infrared spectroscopy (FTIR), and in vitro dissolution. Furthermore, the in vivo pharmacokinetic behavior and tissue distribution after pulmonary administration were also evaluated. Results showed that the drug dissolution was significantly enhanced by processing into curcumin-DPIs. The aerodynamic results indicated that the DPIs displayed a good aerosol performance. The plasma curcumin concentration was obviously enhanced by inhalation, and most of the curcumin-DPIs were deposited in the lung. This study demonstrated that inhalation was an effective way to carry drug to the lung, and curcumin-DPIs were hopeful for lung cancer treatment in the future.

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Section: Introductionmentioning

confidence: 99%

Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo

Hu¹,

Kong²,

Hu³

et al. 2016

Nano Online

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“…Peanut oil is primarily used as a solvent in sustained release intramuscular injections (Wei et al 2013). It is also used as vehicle in topical preparations and as edible oil in Asian countries.…”

Section: Peanut Oilmentioning

confidence: 99%

Excipients in Pediatric Formulations: Biopharmaceutical and Toxicological Considerations

Vangara¹,

Yellepeddi

2015

Excipient Applications in Formulation Design and Drug Delivery

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Excipients are commonly used in pharmaceutical formulations for a variety of applications such as solubility and stability enhancement, taste-masking, tablet compaction, etc. Excipients are also used in the preparation of pediatric formulations for purposes similar to that of adult formulations. However, excipients that are used in adult formulations may not be suitable for the development of formulations for pediatric use due to toxicity concerns. Toxicity of excipients in pediatric populations is mainly due to rapid developmental changes, slower metabolism and elimination, and varied organ and body composition. For example, solvents such as ethanol and propylene glycol that are commonly used in pediatric formulations as solubility enhancers, showed life-threatening adverse events. Therefore, it is apparent that the use of excipients in pediatric formulations requires additional risk assessment by practitioners to avoid potential toxicity issues. Regulatory agencies in the United States of America and Europe are working together to create and maintain a database of Safety and Toxicity of Excipients for Pediatrics (STEP). The purpose of this book chapter is to review the role of excipients and their toxicity in pediatric formulations along with strategies to mitigate the potential risks of toxicity associated with their use in pediatric patients.

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“…After intravenous administration of CUR-NS, it was found that AUC for the CUR-NS was 3.8-fold greater than CUR solution, and the mean residence time was 11.2-fold longer for CUR-NS formulation [34], and the relative bioavailability of CUR-NS to CUR suspension was 680.03% [35]. Oily nanosuspensions for long acting intramuscular delivery of CUR have successfully been developed [36]. These formulations provided significant higher plasma CUR concentration [36] (Table 1).…”

Section: Nanocrystals Nanosuspension and Nano-conjugatesmentioning

confidence: 99%

“…Oily nanosuspensions for long acting intramuscular delivery of CUR have successfully been developed [36]. These formulations provided significant higher plasma CUR concentration [36] (Table 1).…”

Section: Nanocrystals Nanosuspension and Nano-conjugatesmentioning

confidence: 99%

Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

Ahmad

Alkahtani

Akhter

et al. 2015

Journal of Drug Targeting

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Comprehensive pharmacological screening of curcumin (CUR) has given the evidence that it is an excellent naturally occurring therapeutic moiety for cancer. It is very well tolerated with insignificant toxicity even after high doses of oral administration. Irrespective of its better quality as an anticancer agent, therapeutic application of CUR is hampered by its extremely low-aqueous solubility and poor bioavailability, rapid clearance and low-cellular uptake. A simple means of breaking up the restrictive factor of CUR is to perk-up its aqueous solubility, improve its bioavailability, protect it from degradation, and metabolism and potentiate its targeting capacity towards the cancer cell. The development in the field of nanomedicine has made excellent progresses toward enhancing the bioavailability of lipophilic drugs like CUR. Nanoparticles (NPs) are capable to deliver the CUR at specific area and thereby prevent it from physiological degradation and systemic clearance. In recent year, an assortment of nanomedicine-based novel drug delivery system has been designed to potentiate the bioavailability of CUR towards anticancer therapy. In this review, we discuss the recent development in the field of nanoCUR (NanoCur), including polymeric micelles, liposome, polymeric NPs, nanoemulsion, nanosuspension, solid lipid NPs (SLNPs), polymer conjugates, nanogel, etc. in anticancer application.

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Oily nanosuspension for long-acting intramuscular delivery of curcumin didecanoate prodrug: Preparation, characterization and in vivo evaluation

Cited by 41 publications

References 21 publications

Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo

Evaluation of High-Performance Curcumin Nanocrystals for Pulmonary Drug Delivery Both In Vitro and In Vivo

Excipients in Pediatric Formulations: Biopharmaceutical and Toxicological Considerations

Progress in nanotechnology-based drug carrier in designing of curcumin nanomedicines for cancer therapy: current state-of-the-art

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