Oil, water, and surfactant: properties and conjectured structure of simple microemulsions

Evans, D. F.; Mitchell, David J.; Ninham, Barry W.

doi:10.1021/j100404a009

Cited by 213 publications

(121 citation statements)

References 7 publications

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“…Since toluene is a nonsolvent for (7). The picture we are proposing here for the packing of diblock copolymer amphiphiles at solid-fluid interfaces bears some resemblance to the models proposed by Ninham and coworkers (8,9) for the packing of low molecular weight amphiphiles at fluid-fluid interfaces in various surfactant microstructures.…”

Section: Di-block Copolymerssupporting

confidence: 67%

Polymeric amphiphiles at solid-fluid interfaces: Forces between layers of adsorbed block copolymers

Tirrell

Patel

Hadziioannou

1987

Proc. Natl. Acad. Sci. U.S.A.

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Block copolymers are macromolecular amphiphiles and as such have a wide variety of interesting interfacial behavior. We present here a case of block copolymer adsorption from solution studied by the direct measurement of forces between two adsorbed layers. The case is polystyrene (PS)-poly(2-vinylpyridine) (PVP) adsorbed on mica from toluene. Under these circumstances a layer of frmly anchored PS cilia (or loops in the case of PVP-PS-PVP tri-blocks) is assembled on the surface. Furthermore, the PS cilia adopt an extended chain configuration due to lateral crowding imposed on them by the high graft density. The long-range repulsive forces measured in toluene are direct evidence for the wellknown efficacy of this sort of macromolecule in the stabilization of colloidal dispersions. The picture of the adsorbed configuration for di-block copolymers is reasonably clear; that for tri-blocks is less so. Some thoughts are offered on new experiments and technological uses of these materials.

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Section: Di-block Copolymerssupporting

confidence: 67%

Polymeric amphiphiles at solid-fluid interfaces: Forces between layers of adsorbed block copolymers

Tirrell

Patel

Hadziioannou

1987

Proc. Natl. Acad. Sci. U.S.A.

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“…Lecithin has a packing parameter around 0.8 [15] and this value is further increased if the oil phase penetrates into the alkyl chains of the lecithin molecule [16]. In order to produce fine oil-in-water emulsions or microemulsions, it is necessary to reduce this parameter by using co-surfactants, generally short-chain alcohols [17], thus allowing the interfacial film sufficient flexibility to take up the curvature required to form fine emulsions or microemulsions.…”

Section: Resultsmentioning

confidence: 99%

Stability of drug-carrier emulsions containing phosphatidylcholine mixtures

Trotta

Pattarino²,

Ignoni

2002

European Journal of Pharmaceutics and Biopharmaceutics

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Lipid emulsion particles containing 10% of medium chain triglycerides were prepared using 2% w/w of a mixture 1:1 w/w of purified soya phosphatidylcholine and 2-hexanoyl phosphatidylcholine as emulsifier mixture, for use as drug carriers. The mean droplet sizes of emulsions, prepared using an Ultra Turrax or a high-pressure homogenizer, were about 288 and 158 nm, respectively, compared with 380 and 268 nm for emulsions containing lecithin, or 325 and 240 nm for those containing 6-phosphatidylcholine. The stability of the emulsions, determined by monitoring the decrease of a lipophilic marker at a specified level within the emulsion, and observing coalescence over time, was also greatly increased using the emulsifier mixture. The emulsion stability did not notably change in the presence of a model destabilizing drug, indomethacin. The use of a second hydrophilic surfactant to adjust the packing properties of the lecithin at the oil-water interface provided an increase in the stability of lipid emulsions, and this may be of importance in the formulation of drug delivery systems. q

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“…It is well known that electrolytes can diminish the effective polar area of surfactants by screening electrostatic repulsion (5b, 14). This increases the curvature parameter of the surfactant, called the "critical packing parameter" (15). This parameter is defined as ν/al, where ν is the effective volume of a surfactant molecule, l the length of its hydrocarbon chain, and a the effective area of its polar head.…”

Section: Discussionmentioning

confidence: 99%

Effects of Alkylamines on the Percolation Phenomena in Water/AOT/Isooctane Microemulsions

García‐Río

Hervés

Mejuto

et al. 2000

Journal of Colloid and Interface Science

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Oil, water, and surfactant: properties and conjectured structure of simple microemulsions

Cited by 213 publications

References 7 publications

Polymeric amphiphiles at solid-fluid interfaces: Forces between layers of adsorbed block copolymers

Polymeric amphiphiles at solid-fluid interfaces: Forces between layers of adsorbed block copolymers

Stability of drug-carrier emulsions containing phosphatidylcholine mixtures

Effects of Alkylamines on the Percolation Phenomena in Water/AOT/Isooctane Microemulsions

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