Oil-Loaded Monolinolein-Based Particles with Confined Inverse Discontinuous Cubic Structure (<i>Fd</i>3<i>m</i>)

Yaghmur, Anan; Campo, Liliana de; Salentinig, Stefan; Sagalowicz, Laurent; Leser, Martin E.; Glatter, Otto

doi:10.1021/la052109w

Cited by 168 publications

(193 citation statements)

References 39 publications

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“…The eight large spheres have 4 3m symmetry and are arranged tetrahedrally on a diamond lattice and the sixteen small spheres have 3 m symmetry. [26] The formation of this cubic Fd3 m mesostructure may be closely related to the characteristic phase behaviors of reverse PPO-PEO-PPO copolymers Angewandte Chemie ( Figure 1). [27] The sequence of PPO and PEO segments greatly influences the physicochemical behaviors of these copolymers in water, therefore the reverse PPO-PEO-PPO copolymers are very different from PEO-PPO-PEO not only in configuration but also in their micellization properties.…”

mentioning

confidence: 82%

Formation of Mesoporous Carbon With a Face‐Centered‐Cubic Fd$\bar 3$m Structure and Bimodal Architectural Pores From the Reverse Amphiphilic Triblock Copolymer PPO‐PEO‐PPO

et al. 2007

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Diamond, a crystalline form of carbon, shows exceptional physical and chemical properties, such as the highest known hardness and elastic modulus. These characteristics have been attributed to its specific 3D atomic packing and strong sp 3 tetrahedral covalent bonds. [1,2] Attempts to design analogous materials, including molecular sieves and metal-organic frameworks (MOFs), [3,4] have centered on ensuring the same packing as that of diamond, which has 3D facecentered-cubic Fd3 m symmetry.Ordered mesoporous materials have received enormous attention owing to their high surface areas, regular frameworks, and large pore sizes with narrow distribution, all of which lead to multiple potential applications. [5,6] Ordered mesoporous carbon, which is one of the most promising materials, possesses both remarkable functional properties and excellent chemical/thermal stability, which makes it suitable for applications in catalysis, [7] sensing, [8] bioreactor construction, [9] and energy storage. [10] Recently, a family of highly ordered mesoporous carbon with p6mm, Im3 m, and Ia3 d symmetries has been synthesized by an organic-organic self-assembly strategy with PEO-PPO-PEO triblock copolymers as templates (PPO: polypropyleneoxide; PEO: polyethyleneoxide). [11][12][13][14][15] Among the various mesostructures, 3D cubic mesopore geometries are attractive owing to their promise, especially in host-guest chemistry. [16,17] However, the synthesis of mesoporous materials with a 3D cubic Fd3 m structure, which is a unique structure with a bimodal pore size distribution, has not been reported to date by using triblock copolymers as templates. This attractive mesostructure with a silicate composition has only been obtained thus far by using laboratory-made tri-head-group cationic (for FDU-2) [18] and anionic (for AMS-8) surfactants as templates [19,20] under very strict synthetic conditions. In addition, the mesoporous silicas obtained have small lattice parameters and their bimodal mesopore systems cannot be detected by N 2 sorption measurements owing to the smaller size of the surfactant molecules compared to block copolymers.Amphiphilic PEO-PPO-PEO triblock copolymers, which are commercially available as Pluronics or Synperonics, have been proven to be versatile and efficient templates for the fabrication of ordered mesoporous silicas with different symmetries.[21] PPO-PEO-PPO triblock copolymers are another family of commercial surfactants that have the hydrophilic PEO block located in the middle and the hydrophobic PPO blocks at either end of the polymer chain. They are rarely used in the synthesis of ordered mesoporous silicas, however, because of the difficulty of forming oil-inwater micelles. [22][23][24] Reverse PPO-PEO-PPO copolymers with long PEO segments can reduce the curving energy and result in micellar interconnected networks, [24] the possible fascinating phase behaviors of which may provide them with good structure-directing properties for the fabrication of facecentered-cubic Fd3 m mesostructures with high curv...

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confidence: 82%

Formation of Mesoporous Carbon With a Face‐Centered‐Cubic Fd$\bar 3$m Structure and Bimodal Architectural Pores From the Reverse Amphiphilic Triblock Copolymer PPO‐PEO‐PPO

et al. 2007

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“…This occurs, for example, when the viscosity is too high to slow down transport phenomena, and thus, relaxation mechanisms. One example is the micellar cubic (Fd3m)-hexagonal transition occurring in monoglycerides-water-tetradecane systems upon increase of temperature (Yaghmur et al, 2006). Because diffusion is greatly delayed in the highly viscous Fd3m phase, the hexagonal phase may not be attained within standard measuring times upon increasing temperatures.…”

Section: Liquid-crystalline Phases In Foodsmentioning

confidence: 99%

Equilibrium and non-equilibrium structures in complex food systems

Mezzenga

2007

Food Hydrocolloids

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The physics ruling the macroscopic behaviour of foods is discussed in a few selected examples in which the equilibrium/nonequilibrium nature can be directly related to the typical length scale of the food structure and the specific interaction strength, the latter describing the decrease in specific free energy (e.g., per mole of species or per single event) when going from a non-equilibrium to the equilibrium configuration. Liquid-crystalline phases in foods, such as those based on self-assembled lipids and water, are discussed as an example of equilibrium system, in which low correlation length scales ($nm) enable very-short times to re-organize molecules into equilibrium configurations. High internal phase emulsions and dry foams where length scales are very large ($10 1 -10 4 mm), are discussed as a typical example of non-equilibrium system, which however, can be stable for long times owing to the high free energy barrier and the large correlation lengths. Finally double emulsion systems are considered as an example where both interaction strength and correlation lengths have intermediate values. This allows tuning morphologies and making equilibrium behaviour to prevail over non-equilibrium by suitably tailoring the energetic interactions. In particular the case of osmotic pressure in the water phase of water/oil/water double emulsions is discussed as a viable route to control interaction strength in complex food systems.

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“…In lamellar phases and hexagonal phases, the q values of the Bragg peaks are in the ratios 1:2:3:4:5 and 1:1.73:2:2.64:3:3.46, respectively. 44,49,54 The microstructure lattice parameters are represented by the distance between planes (d, lamellar structures) and the hexagon edge (a) that is related to the distance between the planes passing through the two rows of adjacent cylinders (d, hexagonal structure). 55 The distances between planes (d) were 8.49, 7.85, and 8.05 nm for F1, F2, and F3, respectively, and the hexagon edges (a) for F2 and F3 were 9.06 and 9.30 nm, respectively.…”

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confidence: 99%

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

Fonseca-Santos

Santos

Rodero

et al. 2016

IJN

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From previous studies, it has been found that curcumin exhibits an anti-inflammatory activity and is being used for the treatment of skin disorders; however, it is hydrophobic and has weak penetrating ability, resulting in poor drug transport through the stratum corneum. The aim of this study was to develop liquid crystalline systems for topical administration of curcumin for the treatment of inflammation. These liquid crystalline systems were developed from oleic acid, polyoxypropylene (5) polyoxyethylene (20) cetyl alcohol, and water as the surfactant, oil phase, and aqueous phase, respectively. These systems were characterized, and polarized light microscopy showed anisotropy with lamellar mesophases (Formulation 1) and hexagonal mesophases (Formulations 2 and 3), which were confirmed by the peak ratio measured using small-angle X-ray scattering. In addition, rheological tests revealed that the formulations exhibited gel-like behavior (G′>G″), as evidenced by the increased G′ values that indicate structured systems. Texture profile analysis showed that hexagonal mesophases have high values of hardness, adhesiveness, and compressibility, which indicate structured systems. In vitro studies on bioadhesion revealed that the hexagonal mesophases increased the bioadhesiveness of the systems to the skin of the pig ear. An in vivo inflammation experiment showed that the curcumin-loaded hexagonal mesophase exhibited an anti-inflammatory activity as compared to the positive control (dexamethasone). The results suggest that this system has a potential to be used as a bioadhesive vehicle for the topical administration of curcumin. Therefore, it is possible to conclude that these systems can be used for the optimization of drug delivery systems to the skin.

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Oil-Loaded Monolinolein-Based Particles with Confined Inverse Discontinuous Cubic Structure (Fd3m)

Cited by 168 publications

References 39 publications

Formation of Mesoporous Carbon With a Face‐Centered‐Cubic Fd$\bar 3$m Structure and Bimodal Architectural Pores From the Reverse Amphiphilic Triblock Copolymer PPO‐PEO‐PPO

Formation of Mesoporous Carbon With a Face‐Centered‐Cubic Fd$\bar 3$m Structure and Bimodal Architectural Pores From the Reverse Amphiphilic Triblock Copolymer PPO‐PEO‐PPO

Equilibrium and non-equilibrium structures in complex food systems

Design, characterization, and biological evaluation of curcumin-loaded surfactant-based systems for topical drug delivery

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