Oil from hake (Merluccius merluccius): Characterization, antioxidant activity, wound healing and anti-inflammatory effects

Karoud, Wafa; Ghlissi, Zohra; Krichen, Fatma; Kallel, Rim; Bougatef, Hajer; Zarai, Zied; Boudawara, Tahia; Sahnoun, Zouheir; Sila, Assaâd; Bougatef, Ali

doi:10.1016/j.jtv.2020.01.002

Cited by 10 publications

(4 citation statements)

References 63 publications

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“…The slight differences in the lipid profile of salmon viscera compared to that of salmon heads and backbones (Table 2) could influence the different antioxidant activity observed. Chemical antioxidant assays have also showed the antioxidant capacity of oil from salmon belly part, trimmed muscle, backbones, and skin (Haq, Ahmed, Cho, & Chun, 2017) as well as from hake heads (Karoud et al, 2020).…”

Section: Bioactivities Of Salmon Oils Obtained By Se and Optimal Mae ...mentioning

confidence: 99%

Nutritional and bioactive oils from salmon (Salmo salar) side streams obtained by Soxhlet and optimized microwave-assisted extraction

et al. 2022

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Section: Bioactivities Of Salmon Oils Obtained By Se and Optimal Mae ...mentioning

confidence: 99%

Nutritional and bioactive oils from salmon (Salmo salar) side streams obtained by Soxhlet and optimized microwave-assisted extraction

et al. 2022

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“…The free radical scavenging abilities of antioxidants can be assessed by DPPH, which is an organic compound composed of stable free radical molecules [ 16 ]. Here, TBHQ was used as a positive control to assess the antioxidant activity of emu oil.…”

Section: Resultsmentioning

confidence: 99%

“…The carotenoid content of the emu oil was detected using a previously reported method with some modifications [ 16 ]. 3 g of emu oil was dissolved in 10 mL of hexane, and a Cary 50 Conc UV-Vis spectrophotometer (Varian Australia Pty.…”

Section: Methodsmentioning

confidence: 99%

Chemical Characterization and In Vivo Toxicological Safety Evaluation of Emu Oil

Lan

Luo

et al. 2022

Nutrients

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In this study, the physicochemical properties, fatty acid composition, antioxidant activities, and in vitro as well as in vivo toxicological safety of emu oil were investigated. Emu oil was shown to have a low acid and peroxide value, low amounts of carotenoid and phenolic compounds, and high doses of oleic acid and linoleic acid. Furthermore, in a bacterial reverse mutation assay, emu oil demonstrated no change in the amount of revertant colonies for all strains. In a chromosomal assay, no aberrations occurred in any of the emu oil treatment groups (1.25, 2.5, and 5 μg/mL). In the bone marrow micronucleus test, emu oil up to 20 mL/kg showed no significant increase in the incidence of micronucleated polychromatic erythrocytes. Moreover, emu oil up to 19.3 mg/kg body weight did not affect body weight in an acute oral toxicity study. These results are crucial for the adoption of emu oil as an alternative source of edible oil.

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“…However, the accumulation of DHA, EPA, and their functional metabolites is limited at the wound site in the form of oral delivery, owing to the loss in the digestion, absorption, and metabolizing procedures. Compared with oral delivery, local application is a more direct way, and is usually more efficient for wound cure [ 16 ]. Therefore, KO was studied for its effect on diabetic wound healing in streptozotocin (STZ) and high-fat diet (HFD)-induced type 2 diabetic mice.…”

Section: Introductionmentioning

confidence: 99%

Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice

Hao

Meng

et al. 2022

Nutrients

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Diabetes mellitus (DM) impairs the wound healing process, seriously threatening the health of the diabetic population. To date, few effective approaches have been developed for the treatment of diabetic wounds. Krill oil (KO) contains bioactive components that have potent anti-inflammatory and anti-oxidative activities. As prolonged inflammation is a crucial contributor to DM-impaired wound healing, we speculated that the local application of KO would accelerate diabetic wound healing. Therefore, KO was applied to artificially created wounds of type 2 diabetic mice induced by streptozotocin and high-fat diet. The diabetic mice had a delayed wound healing process compared with the non-diabetic control mice, with excessive inflammation, impaired collagen deposition, and depressed neovascularization in the wound area. These effects were dramatically reversed by KO. In vitro, KO blocked the TNF-α-induced macrophage inflammation, fibroblast dysfunction, and endothelial angiogenic impairment. The present study in mice suggests that KO local application could be a viable approach in the management of diabetic wounds.

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Oil from hake (Merluccius merluccius): Characterization, antioxidant activity, wound healing and anti-inflammatory effects

Cited by 10 publications

References 63 publications

Nutritional and bioactive oils from salmon (Salmo salar) side streams obtained by Soxhlet and optimized microwave-assisted extraction

Nutritional and bioactive oils from salmon (Salmo salar) side streams obtained by Soxhlet and optimized microwave-assisted extraction

Chemical Characterization and In Vivo Toxicological Safety Evaluation of Emu Oil

Local Application of Krill Oil Accelerates the Healing of Artificially Created Wounds in Diabetic Mice

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