2001
DOI: 10.1128/jb.183.14.4134-4141.2001
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OhrR Is a Repressor of ohrA , a Key Organic Hydroperoxide Resistance Determinant in Bacillus subtilis

Abstract: Bacillus subtilis displays a complex adaptive response to the presence of reactive oxygen species. To date, most proteins that protect against reactive oxygen species are members of the peroxide-inducible PerR and B regulons. We investigated the function of two B. subtilis homologs of the Xanthomonas campestris organic hydroperoxide resistance (ohr) gene. Mutational analyses indicate that both ohrA and ohrB contribute to organic peroxide resistance in B. subtilis, with the OhrA protein playing the more importa… Show more

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Cited by 198 publications
(283 citation statements)
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“…Like other general stress response genes, ohrB is induced by heat shock, entry into stationary phase and various oxidants and organic alcohols (Volker et al, 1998). In contrast, ohrA is selectively induced by organic peroxides (Fuangthong et al, 2001). Regulation of ohrA is mediated by OhrR, encoded by a convergent gene.…”
Section: The Ohrr Familymentioning
confidence: 99%
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“…Like other general stress response genes, ohrB is induced by heat shock, entry into stationary phase and various oxidants and organic alcohols (Volker et al, 1998). In contrast, ohrA is selectively induced by organic peroxides (Fuangthong et al, 2001). Regulation of ohrA is mediated by OhrR, encoded by a convergent gene.…”
Section: The Ohrr Familymentioning
confidence: 99%
“…OhrR binds to a pair of inverted repeat sequences overlapping the ohrA promoter site (Fig. 1C) and thereby blocks transcription initiation (Fuangthong et al, 2001;.…”
Section: The Ohrr Familymentioning
confidence: 99%
See 1 more Smart Citation
“…Interestingly, a second organic peroxide resistance gene, ohrB, is under control of B (11). The role of Ohr proteins in organic peroxide resistance has now been demonstrated in Xanthomonas campestris, Pseudomonas aeruginosa, Enterococcus faecalis, Actinobacillus pleuropneumoniae, and B. subtilis (10,(12)(13)(14)(15)(16). In many organisms, ohr genes are flanked by genes encoding OhrR homologs (9).…”
Section: R Eactive Oxygen Species (Ros) Including H 2 O 2 Superoximentioning
confidence: 99%
“…The general stress response, coordinated by the B protein, includes paralogs of many of these stress proteins including two additional catalases (KatB and KatX) and the MrgA homolog, Dps. OhrR is representative of a recently identified class of peroxide sensors and acts as a repressor of the ohrA organic peroxide resistance gene (9,10). Interestingly, a second organic peroxide resistance gene, ohrB, is under control of B (11).…”
Section: R Eactive Oxygen Species (Ros) Including H 2 O 2 Superoximentioning
confidence: 99%