Ogilvie's syndrome in sickle cell disease

Gürkan, Emel

doi:10.4318/tjg.2012.0397

Cited by 11 publications

(15 citation statements)

References 4 publications

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“…The increased ALT levels observed in this study confirms by the results of a number of studies [11,12]. On the other hand, out of the 31 cases 68% of the patients have aspartate transaminase level above normal value and only 32% patients have serum AST value within normal range.…”

Section: Discussion:-supporting

confidence: 89%

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Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Bhatta¹,

Thapa²,

Ranabhat³

et al. 2017

IJAR

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Background: Sickle cell trait is not usually regarded as a disease state because it may present several types of health complications that are either uncommon or mild and have not been thoroughly investigated. This article aims to describe the relationship between sickle cell trait (SCT) and liver function test (LFT) parameters in tharu community of western tarai region of Nepal. Method: Sixty two (62) subjects divided into control subjects (n = 31) and heterozygous sickle cell patients ( n = 31) were recruited for the study and were investigated for a liver function tests including the measurement of total protein, albumin, globulin, total bilirubin, direct bilirubin, indirect bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) in both groups. Mean, Standard deviation, Students T test analysis were used for analysis of results. Result: The serum total protein, globulin, total bilirubin, indirect bilirubin, aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) were significantly higher in SCT patients than in controls, with P values of 0.014, <0.001, 0.003, 0.006, <0.001, <0.001 and <0.001 respectively. However, there were no significant difference in the mean value of albumin and direct bilirubin. There was strong correlation noticed between AST and LDH in the test group. Conclusion: It appears that abnormal liver function tests in patients with sickle cell trait poses an uncertain threat for liver disease. The liver functions of the SCT patients were significantly compromised as compared to controls. Studies at molecular level are needed to understand the pathophysiology and progression of liver disease in sickle cell anemia. It is advisable that liver function tests be interpreted with caution in these patients.

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Section: Discussion:-supporting

confidence: 89%

“…Gurkan E, et al 2005 also reported hyperbilirubinemia in 13% of the patient [12]. Few studies report the elevation of bilirubin in sickle cell patients [17,18].…”

Section: Discussion:-mentioning

confidence: 97%

Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Bhatta¹,

Thapa²,

Ranabhat³

et al. 2017

IJAR

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“…These include cardiovascular events (stroke, myocardial infarction…), metabolic abnormality (liver or renal failure, electrolyte imbalance..), drug induced (opiates, phenothiazine, antiparkinsonian agents…), infective or inflammatory events (pneumonia, acute pancreatitis…), neoplasia, postsurgical (renal transplantation, caesarean section, gynecological or pelvic surgery, same if it was released under laparoscopic [6], hip surgery), neurological disease (Parkinson, Alzheimer, multiple sclerosis…) and it can occur after a trauma: femoral fracture, spinal or pelvic trauma… [1]. Some other diseases can be associated to ACPO like sickle cell disease [7].…”

Section: Discussionmentioning

confidence: 99%

Acute Colonic Pseudo-Obstruction Associated with Parkinson’s Disease

Motiaa¹

2017

GHOA

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Acute colonic pseudo-obstruction (ACPO) or Ogilvie's syndrome is defined as a massive dilation of the colon in absence of any mechanical obstruction. The majority of patients are midde-aged or elderly. The diagnosis of ACPO is based on Clinical presentation and excluding mechanical obstruction by imaging. Rapid diagnosis is the key, and institution of conservative measures often will lead to resolution. Delays in diagnosis can lead to fatal complications requiring a surgical treatment and increasing mortality. The management of Ogilvie's syndrome is not codified. In this article, we report a case of ACPO in a 42 years old patient with Parkinson's disease and we discuss therapeutic approaches of Ogilvie's syndrome.

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“…Serum ferritin test is the most available method and is easily reproducible, in spite of not providing a good specificity (3) . Hepatic biopsy, in spite of being validated as a reference standard, is an invasive method and, therefore, involves risks inherent to the procedure (4) . For these reasons, the possibility of replacing such a procedure by a noninvasive imaging method, in this case magnetic resonance imaging (MRI), is discussed (5) .…”

Section: Introductionmentioning

confidence: 99%

Sobrecarga de ferro transfusional em portadores de anemia falciforme: comparação entre ressonância magnética e ferritina sérica

Filho¹,

Ferrão

França

et al. 2011

Radiol Bras

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Objective: To identify predictive variables of iron overload in patients with sickle cell anemia, correlating biochemical and imaging markers. Materials and Methods: The authors developed a cross-sectional study involving 32 patients with sickle cell anemia who were evaluated for ferritin and iron serum levels and submitted to liver magnetic resonance imaging with one spin-echo and five gradient-echo sequences. The signal intensity was obtained at each sequence, corresponding to the arithmetical mean of the measurements on regions of interest in the liver and paraspinal muscles to obtain the liver/muscle signal intensity ratio (SIR). Based on such SIR, the liver iron concentration (LIC) was estimated by means of the following formula: e [5.808 -(0.877 × T2*) -(1.518 × IW)] , where T2* is the SIR on the sequence with echo time = 13 ms and IW is the SIR on the intermediate-weighted sequence. Patients were grouped according to their blood transfusion regimen (regular monthly versus sporadic transfusions). Results: The comparison between the transfusion groups was based on clinical-laboratory variables, with significant differences in SIR, LIC and serum ferritin levels: the group with regular transfusions demonstrated greater hepatic iron overload. Conclusion: Magnetic resonance imaging is an efficient tool for evaluating liver iron overload in patients with sickle cell anemia. Keywords: Sickle cell anemia; Magnetic resonance imaging; Ferritin.Objetivo: Identificar variáveis preditoras de sobrecarga de ferro em portadores de anemia falciforme e correlacionar indicadores bioquímicos e imaginológicos. Materiais e Métodos: Foi realizado estudo transversal envolvendo 32 portadores de anemia falciforme, que foram submetidos a dosagem sérica de ferro, ferritina e a ressonância magné-tica do fígado. Foram realizadas cinco sequências gradiente-eco e uma spin-eco. A intensidade de sinal foi obtida em cada sequência pelas médias das regiões de interesse no fígado e musculatura paravertebral para obter a razão da intensidade de sinal (RIS) fígado/músculo. A partir da RIS foi obtida a concentração hepática estimada de ferro (CHEF) pela fórmula: e [5,808 -(0,877 × T2*) -(1,518 × PI)] , onde T2* é a RIS na sequência com TE de 13 ms e PI é a RIS da sequência com ponderação intermediária. Os pacientes foram agrupados segundo o regime de transfusão de hemácias (regulares mensais versus esporádicas). Resultados: Os grupos transfusionais foram comparados pelas variáveis clínico-laboratoriais, sendo significativas as diferenças entre RIS, CHEF e ferritina sérica: o grupo que recebeu transfusões regulares apresentou sobrecarga de ferro hepático mais intensa. Conclusão: A ressonância magnética foi ferramenta eficiente para avaliação de sobrecarga hepática de ferro em portadores de anemia falciforme. Unitermos: Anemia falciforme; Imagem por ressonância magnética; Ferritina. AbstractResumo

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Ogilvie's syndrome in sickle cell disease

Cited by 11 publications

References 4 publications

Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Liver Involvement in Sickle Cell Trait: A Case Control Study Among Nepalese Indigenous Tharu Community.

Acute Colonic Pseudo-Obstruction Associated with Parkinson’s Disease

Sobrecarga de ferro transfusional em portadores de anemia falciforme: comparação entre ressonância magnética e ferritina sérica

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