Ofuji's disease in an immunocompetent patient successfully treated with dapsone

Abstract

Eosinophilic pustular folliculitis or Ofuji's disease is a non-infectious eosinophilic infiltration of hair follicles, which usually presents with itchy papules and pustules in a circinate configuration. We report this case of an immunocompetent patient with erythematous papules and plaques without macropustules diagnosed as eosinophilic pustular folliculitis—a rarely reported entity outside Japan. He was successfully treated with oral dapsone.

Acute Generalized Exanthematous Pustulosis: Clinical Features, Differential Diagnosis, and Management

“…There may be micro-abscesses of eosinophils within the follicular epithelium [ 5 , 215 ]. Ofuji disease is classically not accompanied by any systemic symptoms; however, peripheral eosinophilia is a common finding [ 216 ]. Ofuji disease often recurs or is chronic, most commonly in patients with HIV or individuals aged in their 30s and is most well-characterized in Japanese women [ 211 – 213 , 216 ].…”

“…Ofuji disease is classically not accompanied by any systemic symptoms; however, peripheral eosinophilia is a common finding [ 216 ]. Ofuji disease often recurs or is chronic, most commonly in patients with HIV or individuals aged in their 30s and is most well-characterized in Japanese women [ 211 – 213 , 216 ]. There have been no reported cases of concurrent or overlapping Ofuji disease and AGEP.…”

Uncommon localisation of Ofuji disease in a Moroccan patient

“…(2) immunosuppression-associated EPF (mostly HIV-associated EPF, malignant haemopathies and organ transplant) and ( 3) an observed form on children, characterised by papulopustular lesions surmounted by crusts, extremely itchy and mainly spreading on the scalp. 2 Histopathology is of crucial value for diagnosis confirmation, describing infundibular spongiosis, dermal infiltration of inflammatory cells with perifollicular and perivascular eosinophils, and some neutrophils and mononuclear cells.…”

Diseases in Skin of Color

“…A neonatal/infantile variant, occasionally triggered by infestations as well as HIV-associated eosinophilic pustular folliculitis, is also known. Therapy Indomethacin 50-75 mg/day and/or topical and oral glucocorticoids; in therapeutically difficult situations also systemic dapsone and topical tacrolimus 0.03% (Anjaneyan et al 2016).…”