Ofloxacin compared with chloramphenicol in the management of external ocular infection.

Bron, Anthony J.; Leber, G.; Rizk, Sanaa; Baig, Hassan; Elkington, A R; Kirkby, G R; Neoh, Chin Fen; Harden, Albert S.; Leong, Trevor

doi:10.1136/bjo.75.11.675

Cited by 27 publications

(9 citation statements)

References 31 publications

(1 reference statement)

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“…In several randomised controlled trials both ciprofloxacin and ofloxacin eyedrops (0.3%) were comparable to conventional topical preparations such as chloramphenicol and gentamicin in the treatment of superficial eye infections 11–16. Ofloxacin is as effective and safe as chloramphenicol,11 gentamicin12 and tobramycin13 in the treatment of bacterial external ocular disease (e.g.…”

Section: Clinical Studiesmentioning

confidence: 98%

“…Ofloxacin is as effective and safe as chloramphenicol,11 gentamicin12 and tobramycin13 in the treatment of bacterial external ocular disease (e.g. blepharitis and conjunctivitis).…”

Section: Clinical Studiesmentioning

confidence: 99%

“…Both ciprofloxacin and ofloxacin eyedrops can irritate the eye after instillation 11–13 , 15 , 16. In high doses, ciprofloxacin causes the deposition of a white precipitate on the surface of the eye, which resolves with a reduction in dosage or after stopping the drug 15…”

Section: Unwanted Effectsmentioning

confidence: 99%

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Fluoroquinolones for the eye

1994

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Two fluoroquinolone antibiotics, ciprofloxacin (Ciloxan - Alcon) and ofloxacin (Exocin - Allergan), are available in the UK as topical preparations for the eye.* Ciprofloxacin eyedrops are licensed for the treatment of "corneal ulcers and superficial infections of the eye", and ofloxacin eyedrops for "external ocular infections (such as conjunctivitis and keratoconjunctivitis)". In the UK chloramphenicol is commonly recommended as the drug of first choice for the treatment of superficial bacterial eye infections.1,2 Do fluoroquinolone preparations offer any advantage over this or other established drugs?

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Section: Clinical Studiesmentioning

confidence: 98%

“…Ofloxacin is as effective and safe as chloramphenicol,11 gentamicin12 and tobramycin13 in the treatment of bacterial external ocular disease (e.g. blepharitis and conjunctivitis).…”

Section: Clinical Studiesmentioning

confidence: 99%

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Fluoroquinolones for the eye

1994

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“…These include stinging and local discomfort 19–21. Local allergic reactions can occur, causing uncomfortable red itchy eyes, symptoms that are similar to conjunctivitis itself 22.…”

Section: Unwanted Effectsmentioning

confidence: 99%

Management of acute infective conjunctivitis

2011

DTB

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Eye conditions account for 2-5% of all consultations in general practice.1 One-third of these eye problems (equivalent to around 13-14 cases per 1,000 population per year) are cases of infective conjunctivitis, normally a self-limiting condition.2,3 Traditionally, topical antibacterials have been prescribed for people with acute infective conjunctivitis.4 In 2005, chloramphenicol eye drops became available over the counter (OTC) from UK pharmacies as a treatment for conjunctivitis, and there is evidence that the overall use of chloramphenicol for this indication has increased since then.5 Here we review the evidence on the efficacy of antibacterials in acute infective conjunctivitis. We also offer practical information and advice for prescribers and community pharmacists on managing patients with the condition.

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“…Both of these fluoroquinolones are well established representative ophthalmic antibiotics with ofloxacin classified in the second-and levofloxacin in the third-generation [18]. Their great efficacy against the most frequent Grampositive and Gram-negative ocular pathogenic bacteria have made these fluoroquinolones an excellent initial choice for the topical therapy of external ocular infections [2,5,14,20,21,23]. Pharmacokinetic characteristics such as low molecular weight, lipophilic properties for better corneal permeability and intraocular uptake [8,22] have raised interest in using fluoroquinolones for prevention of postoperative endophthalmitis [11,24].…”

Section: Introductionmentioning

confidence: 99%