Ofloxacin

Mouton, Y; Leroy, Olivier

doi:10.1016/0924-8579(91)90001-t

Cited by 19 publications

(5 citation statements)

References 103 publications

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“…The inhibition of DNA replication triggers a bacterial reaction (SOS response), eventually leading to cell death. The SOS response is a particular feature of the action of 4-quinolone and consists of the induction of nonreplicating DNA synthesis and inhibition of cell division leading to filamentation (Mouton and Leroy, 1991;Crosby et al, 1994). Based on our results, the anti-H. pylori activity of WCC is similar to that of fluoroquinolones and is distinct from other antibiotics.…”

supporting

confidence: 53%

In Vitro Anti-Helicobacter pylori Activity of Chinese Chive (Allium tuberosum)

Kudo

Takeuchi

Shimamura

et al. 2011

FSTR

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The anti-Helicobacter pylori (H. pylori) activity of a water extract of Chinese chive (Allium tuberosum) (WCC) was investigated. On disk diffusion assay, WCC effectively inhibited the growth of all 21 strains tested, including isogenic mutants, showing inhibition diameters of 12 to 29 mm, irrespective of drug susceptibility and clinical manifestation. The minimum inhibitory concentration (MIC) of WCC was 2.45 mg dry weight/mL. Killing assay with multiples of MIC confirmed that WCC had bactericidal activity and that the inhibitory effects were dose dependent. In addition, to determine whether the inhibitory activity of WCC under severe stress conditions, such as heat and acidity, is altered, the stability of WCC was evaluated. The inhibitory activity of WCC exposed to acidic conditions (pH 1.0 to 6.4) was stable, while heat-treated WCC (100℃, 10 min) showed slightly decreased inhibition activity. On combination assay with antibiotics frequently used in clinical practice, WCC was found to be an innocuous agent for antibiotic activity. These results suggest that daily intake of WCC is able to prevent H. pylori colonization in the stomach, and that it could be applied as adjuvant therapy in H. pylori eradication.Keywords: Helicobacter pylori, Chinese chive, Allium tuberosum, antibiotic resistance, growth inhibition effect, bactericidal activity * To whom correspondence should be addressed. *E-mail: htake@kochi-u.ac.jp (H. Takeuchi) tomokos@kochi-u.ac.jp (T. Shimamura) IntroductionHelicobacter pylori (H. pylori) was recognized as a human carcinogen by IARC in 1994(Sugiyama et al., 2002, and is a pathogenic gram-negative spiral microaerophilic bacterium that colonizes the human stomach in up to half the world's population (Rothenbacher and Brenner, 2003). H. pylori plays a major role in the development of gastro-duodenal diseases, including gastritis, peptic ulcer and gastric cancer, and is associated with a wide range of non-gastrointestinal tract conditions such as idiopathic thrombocytopenic purpura. As gastric cancer is one of the most frequent causes of cancer-related death, eradication of H. pylori can, therefore, contribute to the treatment and prevention of these diseases. Generally, H. pylori infection in clinical practice is treated with an effective regimen, a triple therapy consisting of a proton pump inhibitor and combinations of two antibiotics; amoxicillin (AMPC) and clarithromycin (CAM) or AMPC and metronidazole (MNZ) in Japan (Nishimori, et al., 2006). However, unsuccessful eradication therapy is increasing due to the increased occurrence of drug-resistant H. pylori (Nariman, et al., 2004). The appearance rates of drug-resistant H. pylori against AMPC, CAM and MNZ from 2007to 2009 were 0.4%, 19.4% and 25.7%, respectively (Lyudmila et al., 2010, and these rates are continuing to escalate.Instead of antibiotics, non-antibiotic substances derived from foods with anti-H. pylori activity are now a focus in Gastroenterology. There have been several reports on natural compounds derived from foods, includin...

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supporting

confidence: 53%

In Vitro Anti-Helicobacter pylori Activity of Chinese Chive (Allium tuberosum)

Kudo

Takeuchi

Shimamura

et al. 2011

FSTR

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“…With relatively low protein binding, rapid body tissue penetration and a mean elimina tion half-life of 5-8 h, ofloxacin has been a clinical success [3], In Canada, ofloxacin has been commer cially available for about 24 months, while ci profloxacin and norfloxacin have been avail able for 5 and 8 years, respectively.…”

Section: Introductionmentioning

confidence: 99%

Canadian Ofloxacin Susceptibility Study: A Comparative Study from 18 Medical Centers

Hoban

Jones²

1995

Chemotherapy

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Ofloxacin, a newer fluorinated 4-quinolone having a broad spectrum of activity was evaluated against 5,553 clinical pathogens isolated from urine, respiratory tract, skin and genital tract infections at 18 Canadian Medical Centers spread across the nation. Approximately 300 strains were reported (zone diameters) from each site. The zones of ofloxacin, other fluoroquinolones, oral cephalosporins and penicillins were analyzed and interpreted by NCCLS criteria. Ofloxacin had the widest spectrum of activity against gram-positive organisms and most gram-negative organisms, while ciprofloxacin was only superior for the Pseudomonas spp. The percentage of isolates susceptible to ofloxacin was as follows: for respiratory tract pathogens = 94%, for skin and soft tissue infections = 94%, for urinary tract organisms = 93% and for genital tract isolates = 94%.

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“…Pefloxacin is excreted mostly through the gastrointestinal system (85%). All other quinolones are eliminated primarily through the urine (70%), with 30% being excreted in the feces [17][18][19][20][21].…”

Section: Relative Risksmentioning

confidence: 99%