Isolated systolic hypertension (ISH) is defined as systolic blood pressure (SBP) ≥140 mmHg and diastolic blood pressure (DBP)<90 mmHg. 1 The prevalence of ISH increases with age along with the decreasing DBP and the widening pulse pressure (PP). ISH is commonly viewed as the manifestation of vascular aging and is conceivably the most common subtype of hypertension in the elderly population. 2-4 The elderly with ISH have a significantly higher risk of cardiovascular diseases 5,6 and benefit substantially from antihypertensive therapy. 7-9