Off-responses in the auditory system in relation to the signal end phase and neuronal characteristic frequency

Radionova, E. A.

doi:10.1016/0378-5955(88)90120-7

Cited by 8 publications

(4 citation statements)

References 9 publications

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“…OFF responses in the auditory system were reported as early as 1964 (Suga 1964). They have been found in the bat cochlea (Grinnell 1973), in frog auditory nerve fibers (Feng et al 1994), in the cat cochlear nucleus (Young and Brownell 1976), and in the superior olivary complexes (Grothe et al 1992;Kuwada andBatra 1999), the ICs (Brand et al 2000;Cain and Jen 1999;Casseday et al 1994Casseday et al , 2000Grinnell 1970;Lesser et al 1990;Neuweiler et al 1971;O'Neill 1985;Pollak and Bodenhamer 1981;Pollak and Schuller 1981;Radionova 1988), the thalami (Aitkin and Prain 1974;Calford 1983;Calford and Webster 1981;He 2001;Zurita et al 1994), the auditory cortexes (Ahissar et al 1992;Bieser and Muller-Preuss 1996;Hari et al 1987;He et al 1997;Heil and Scheich 1991;Heil et al 1992;Ostwald 1984;Pelleg-Toiba and Wollberg 1989;Toronchuk et al 1992;Zurita et al 1994), and the auditory brain stem responses (Henry 1985a(Henry ,b, 1987aHillyard and Picton 1978;Laukli and Mair 1985) of various mammals. In the bat, it is believed that the OFF response is generated within the cochlea and the OFF tuning frequency is an indicative of the resonance frequency of the organ of Corti (Kössl and Vater 1985;…”

Section: Discussionmentioning

confidence: 99%

offResponses in the Auditory Thalamus of the Guinea Pig

2002

Journal of Neurophysiology

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ON and OFF auditory responses were examined in the medial geniculate body (MGB) of the guinea pig. Single- and multiunit recordings were carried out on 12 anesthetized animals, and noise-burst or pure-tone stimuli were applied to the ear contralateral to the recording hemisphere. One hundred and thirty-five OFF or ON-OFF neurons and 160 ON neurons were studied, and the tuning curves of 21 ON-OFF or OFF neurons were examined from various nuclei of the MGB. The mean minimum threshold of the OFF responses (40.8 +/- 20.0 dB SPL, mean +/- SD; range: 0-80 dB SPL) was significantly higher than that of the ON responses (28.5 +/- 17.6 dB SPL, range: 0-60 dB SPL; n = 17, P < 0.001). Of 10 ON-OFF neurons that showed identifiable tuning frequencies for both ON and OFF responses, 7 showed a higher OFF than ON best frequency (BF), 2 showed the same BF for both ON and OFF, and only 1 showed a slightly lower OFF than ON BF. Most OFF responses sampled from the borders of the ventral (MGv) and the rostromedial (MGrm) nuclei of the MGB showed single-peaked tuning curves, similar to those of the ON responses in the MGv. The neurons located in the shell (MGs) and dorsal (MGd) nuclei of the MGB showed complicated-either multi-peaked or broad-tuning curves. All OFF responses showed long-duration-selectivity for acoustic stimuli: the mean half-maximum duration was 116.5 +/- 114.8 ms (n = 19, range: 27-411 ms). The latencies of 135 OFF responses were studied in various divisions of the MGB. The ventral border region of MGv showed the shortest latency, followed by the dorsal border region of the MGv, the MGrm, and the caudomedial nucleus (MGcm) of the MGB. The posterior nucleus of the thalamus (Po), the MGd, and the MGs showed much longer mean latencies of >30 ms (P < 0.05 compared with the border regions of the MGv, ANOVA), with Po showing the greatest mean latency of 60.3 ms and the greatest deviation of 25.5 ms). The latency of the OFF response (29.0 +/- 14.0 ms, n = 135) was significantly greater than that of the ON response (15.6 +/- 9.6 ms, n = 160, P < 0.001). The present results provide valuable information about the threshold, frequency tuning characteristics, minimal response latency, and duration selectivity of OFF neurons in the auditory thalamus.

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Section: Discussionmentioning

confidence: 99%

offResponses in the Auditory Thalamus of the Guinea Pig

2002

Journal of Neurophysiology

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“…Spectral summation of excitation and inhibition produced by several tones in the excitatory and inhibitory frequency receptive fields of IC neurons happens in critical bands (Ehret & Merzenich, 1985, 1988Egorova & Ehret, 2008;King et al, 2015). Neural critical bands, which seem to emerge from the tonotopic organization and laminar structure of IC neurons (Schreiner & Langner, 1997), define the frequency range of frequency resolution but do not determine the type of response and the response rates that are generated as output.…”

Section: Spectral Summation and Facilitation In Neurons With Differenmentioning

confidence: 99%

“…Hence, mouse wriggling calls can serve as general acoustical models for studies about how and where in the auditory system grouping together of spectrally resolved frequencies to acoustic objects occurs in the neural coding. Here, we study the auditory midbrain (inferior colliculus, IC) for possible neural correlates of spectral grouping of wriggling call frequencies because in the IC, spectral resolution as expressed by neural critical bands has reached, on average, perceptual values (Ehret & Merzenich, 1985, 1988Egorova et al, 2006;King et al, 2015). We hypothesize that responses of IC neurons are improved or better facilitated by combined spectrally resolved than non-resolved frequency components.…”

Section: Introductionmentioning

confidence: 99%

“…Neurons with facilitated responses to certain frequency combinations are called combinationsensitive neurons (Mittmann & Wenstrup, 1995;Leroy & Wenstrup, 2000;Portfors & Felix, 2005;Felix & Portfors, 2007;Peterson et al, 2008). As considerable amounts of IC neurons show offset responses in addition to onset responses to sounds (Ehret & Moffat, 1985;Radionova, 1988;Brand et al, 2000;P erez-Gonz alez et al, 2006;Kasai et al, 2012), we also analyzed neurons with regard to summation and facilitation of off-responses and compare on-and off-response behavior in the contexts of facilitation and spectral resolution. The hypothesis is that spectral facilitation of both on-and off-responses enhances the perception of the duration of single calls and of inter-call intervals (Xu et al, 2014) being important parameters in the perception of wriggling call sequences (Geissler & Ehret, 2002;Gaub & Ehret, 2005) and of vocalization rhythm in general.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Spectral summation and facilitation in on‐ and off‐responses for optimized representation of communication calls in mouse inferior colliculus

Akimov

Егорова

Ehret

2017

Eur J of Neuroscience

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Selectivity for processing of species-specific vocalizations and communication sounds has often been associated with the auditory cortex. The midbrain inferior colliculus, however, is the first center in the auditory pathways of mammals integrating acoustic information processed in separate nuclei and channels in the brainstem and, therefore, could significantly contribute to enhance the perception of species' communication sounds. Here, we used natural wriggling calls of mouse pups, which communicate need for maternal care to adult females, and further 15 synthesized sounds to test the hypothesis that neurons in the central nucleus of the inferior colliculus of adult females optimize their response rates for reproduction of the three main harmonics (formants) of wriggling calls. The results confirmed the hypothesis showing that average response rates, as recorded extracellularly from single units, were highest and spectral facilitation most effective for both onset and offset responses to the call and call models with three resolved frequencies according to critical bands in perception. In addition, the general on- and/or off-response enhancement in almost half the investigated 122 neurons favors not only perception of single calls but also of vocalization rhythm. In summary, our study provides strong evidence that critical-band resolved frequency components within a communication sound increase the probability of its perception by boosting the signal-to-noise ratio of neural response rates within the inferior colliculus for at least 20% (our criterion for facilitation). These mechanisms, including enhancement of rhythm coding, are generally favorable to processing of other animal and human vocalizations, including formants of speech sounds.

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Different phase sensitivity of low- and high-frequency neurons from the cat's cochlear nucleus

Radionova

1990

Hearing Research

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Off-responses in the auditory system in relation to the signal end phase and neuronal characteristic frequency

Cited by 8 publications

References 9 publications

offResponses in the Auditory Thalamus of the Guinea Pig

offResponses in the Auditory Thalamus of the Guinea Pig

Spectral summation and facilitation in on‐ and off‐responses for optimized representation of communication calls in mouse inferior colliculus

Different phase sensitivity of low- and high-frequency neurons from the cat's cochlear nucleus

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