Off-Peak 594-nm Light Surpasses On-Peak 532-nm Light in Silencing Distant ArchT-Expressing Neurons In Vivo

Setsuie, Rieko; Tamura, Keita; Miyamoto, Katsuhiro; Watanabe, Takamitsu; Takeda, Masaki; Miyashita, Yasushi

doi:10.1016/j.isci.2020.101276

Cited by 9 publications

(9 citation statements)

References 62 publications

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“…For bilateral light delivery, Arduino Duos with custom code were used to receive TTL pulses from Med-PC operant chambers and trigger onset of 2 LEDs (595 nm, Thorlabs) coupled to 200 um sheathed fiber optic cable with ferrule-to-ferrule connectivity (> = 1 mW at ferrule tip). We used 595 nm light as this has been shown to optimally activate ArchT while avoiding non-specific effects 54 . We used several different protocols to target the closed-loop inhibition to different task epochs.…”

Section: Methodsmentioning

confidence: 99%

Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment

et al. 2022

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Decision-making is a continuous and dynamic process with prior experience reflected in and used by the brain to guide adaptive behavior. However, most neurobiological studies constrain behavior and/or analyses to task-related variables, not accounting for the continuous internal and temporal space in which they occur. We show mice rely on information learned through recent and longer-term experience beyond just prior actions and reward - including checking behavior and the passage of time - to guide self-initiated, self-paced, and self-generated actions. These experiences are represented in secondary motor cortex (M2) activity and its projections into dorsal medial striatum (DMS). M2 integrates this information to bias strategy-level decision-making, and DMS projections reflect specific aspects of this recent experience to guide actions. This suggests diverse aspects of experience drive decision-making and its neural representation, and shows premotor corticostriatal circuits are crucial for using selective aspects of experiential information to guide adaptive behavior.

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Section: Methodsmentioning

confidence: 99%

Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment

et al. 2022

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“…In the present study, we provided further evidence that the activation of the corticostriatal circuit is crucial for functional recovery induced by exercise treatment. Modulation of circuits using optogenetic technology has been considered a promising therapy in many neurological disorders, such as Parkinson's disease [27][28], stroke [12][13][14][15][16][17][18][19][20][21][22][23][24][25][26][27][28][29], Huntington's disease [30], and psychiatric disorders [31]. We selectively activated cortex-mediated circuit with single optogenetics at the core region of the injection site to evaluate motor function in mice with ischemic stroke.…”

Section: Discussionmentioning

confidence: 99%

Corticostriatal projections relying on GABA levels encode exercise-induced functional recovery in cerebral ischemic mice

Xing,

Zhang,

et al. 2022

Preprint

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Stroke is a neurological disorder characterized by high disability and death worldwide. The occlusion of the middle cerebral artery (MCAO) supplying the motor cortical regions and its projection pathways regions can either kill the cortical neurons or block their projections to the spinal cord and subcortical structure. The cerebral cortex is the main striatal afferent, and the medium spiny neurons of the striatum have been identified as the major output neurons projecting to substantia nigra and pallidum. Thus, disconnection of the corticostriatal circuit often occurs in the model of MCAO. In this study, we hypothesize that striatal network dysfunction in cerebral ischemic mice ultimately modulates the activity of striatal projections from cortical neurons to improve dysfunction during exercise training. In this study, we observed that corticostriatal circuit originating from glutamatergic neurons can partially medicate improvement of motor and anxiety-like behavior in mice with exercise. Furthermore, exercise or activation of a single optogenetic corticostriatal circuit can increase the striatal gamma-aminobutyric acid (GABA) level. Using the GABA-A receptor antagonist, bicuculline, we further identified that the glutamatergic projection of the cortex in the striatum relies on activity of GABAergic synapse to modulate exercise-induced functional recovery. Overall, those results reveal that the dorsal striatum-projecting subpopulation of cortical glutamatergic neurons can influence GABA levels in the striatum, playing a critical role in modulating exercise-induced improvement of motor and anxiety-like behavior.

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“…575 nm was chosen for calculations, because this wavelength corresponds to the absorption peak of blood oxyhemoglobin, and also verified by comparing the spectra of normal and affected tissues 24 . Although this absorption peak for different pure hemoglobin proteins may have some variations, the peak of blood oxyhemoglobin at 575 nm is evident 25,26 …”

Section: Methodsmentioning

confidence: 99%

Optimizing parameters of the Pulsed Dye Laser (PDL, 585‐nm) for hemangioma treatment using diffuse reflectance spectroscopy

Allahdadi

Shirkavand²,

Mohajerani

et al. 2022

J of Cosmetic Dermatology

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Introduction The lack of objectivity options for a specific individualized therapy might cause challenges in laser treatment. In other words, we need optimally determined laser parameters for less side effects. Generally, laser treatment procedures seem to be subjective. Then, the final evaluation of the patient needs for optimized better response with less laser sections and less side effects. Therefore, employing a reliable objective technique seems to be essential for better response with less laser treatment sessions and also less side effects. Method In this research, UV–visible diffused reflection spectra from normal skin and a lesion were taken. We obtained the differences in absorption intensity at 575 nm, the wavelength corresponds to the absorption peak of blood oxyhemoglobin for normal skin and hemangioma. To calibrate the measurements, after using pulsed dye laser (PDL at 585 nm), the PDL treatment response of the patients were graded as “good (>50%), moderate(25%–50%), and poor (0%–25%),” by a specialist. Finally, patients were categorized based on the energy of the laser for the best treatment response to propose the recommended laser parameters. Results Based on the differences in the absorption peak hemangioma compare with normal skin, the energy density of PDL for a good treatment response of hemangioma was obtained at peak wavelength 575 nm. Conclusion The analysis of optical reflection spectroscopy can assess the correlation of absorption peak differences of vascular lesions and normal skin. According to this data, it seems to be effective in optimizing lasers parameters for the hemangioma treatment.

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Off-Peak 594-nm Light Surpasses On-Peak 532-nm Light in Silencing Distant ArchT-Expressing Neurons In Vivo

Cited by 9 publications

References 62 publications

Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment

Information normally considered task-irrelevant drives decision-making and affects premotor circuit recruitment

Corticostriatal projections relying on GABA levels encode exercise-induced functional recovery in cerebral ischemic mice

Optimizing parameters of the Pulsed Dye Laser (PDL, 585‐nm) for hemangioma treatment using diffuse reflectance spectroscopy

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