Off-label uses of trazodone: a review

Bossini, Letizia; Casolaro, Ilaria; Koukouna, Despoina; Cecchini, F; Fagiolini, Andrea

doi:10.1517/14656566.2012.699523

Cited by 68 publications

(46 citation statements)

References 70 publications

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“…14 For humans, there are various indications for administration of trazodone including treatment of depression, anxiety disorders, insomnia, certain causes of pain, and cognitive dysfunction. 15 In dogs, however, reported 3 clinical use of trazodone is limited to chronic management of behavioral disorders, including storm phobias and separation anxiety, and it is typically administered in combination with conventional psychoactive medications. Its broad spectrum of pharmacological action and clinical applications in humans suggests that trazodone may have similar versatility for treatment of companion animals.…”

Section: Discussionmentioning

confidence: 99%

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

Jay¹,

Krotscheck²,

Parsley³

et al. 2013

ajvr

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Results of this study indicated oral administration of trazodone resulted in acceptable absolute bioavailability, with substantial variability in time to maximum plasma concentration. Individualized approaches in dosing intervals may be necessary for dogs receiving oral trazodone. An orally administered dose of 8 mg/kg was well tolerated in dogs; IV administration of a dose of 8 mg/kg caused substantial adverse effects, including tachycardia and behavior disinhibition.

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Section: Discussionmentioning

confidence: 99%

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

Jay¹,

Krotscheck²,

Parsley³

et al. 2013

ajvr

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show abstract

“…Thus, the majority of the prescriptions in the absence of psychiatric diagnoses of MDD and anxiety disorders in this study were likely for mental health complaints that did not meet the criteria for these disorders. While there is some evidence supporting the efficacy of ADs for sub-syndromal depressive symptoms and dysthymic disorder, 25, 26 and for off-label use of ADs in the treatment of sleep disorders, 27 these uses are controversial. 28, 29 …”

Section: Discussionmentioning

confidence: 99%

Antidepressant Use and Lifetime History of Mental Disorders in a Community Sample

Takayanagi

Spira

Bienvenu³

et al. 2014

J. Clin. Psychiatry

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Objectives Past studies have shown that many individuals who use antidepressants do not have a current or lifetime history of mental disorders. However, recent studies suggest that the one-time retrospective evaluation of mental disorders commonly used in such studies may substantially underestimate the true lifetime prevalence of mental disorders. We examined the prevalence of mental disorders, assessed prospectively over multiple interviews, among individuals currently using antidepressants in a community sample. Methods Using data from the Baltimore Epidemiologic Catchment Area (ECA) Survey Wave 1 (1981) through Wave 4 (2004) (N = 1071), we assessed lifetime prevalence of common mood and anxiety disorders according to the DSM-III and DSM-III-R criteria, based on 4 interviews, among participants who reported current antidepressant use. Furthermore, we examined factors associated with current antidepressant use. Results Thirteen percent of participants at Wave 4 reported currently using antidepressant medications. Among antidepressant users, 69% never met criteria for major depressive disorder (MDD), and 38% never met criteria for MDD, obsessive-compulsive disorder, panic disorder, social phobia, or generalized anxiety disorder in their lifetime. Female gender, Caucasian ethnicity, recent or current physical problems (e.g., loss of bladder control, hypertension and back pain) and recent mental health facility visits were associated with antidepressant use in addition to mental disorders. Conclusions Many individuals who are prescribed and use antidepressant medications may not have met criteria for mental disorders. Our data indicate that antidepressants are commonly used in the absence of clear evidence-based indications.

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“…Neither has been proven to be effective for RLS/WED. While there is some evidence for use of trazodone to treat insomnia in depression, there is limited evidence for the treatment of insomnia in the non-depressed population, although such use is common in clinical practice [183][184][185]. A small study found limited efficacy of clonidine for RLS/WED [186].…”

Section: Other Medicationsmentioning

confidence: 99%

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

Picchietti¹,

Hensley²,

Bainbridge³

et al. 2015

Sleep Medicine Reviews

136

106

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Off-label uses of trazodone: a review

Cited by 68 publications

References 70 publications

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

Pharmacokinetics, bioavailability, and hemodynamic effects of trazodone after intravenous and oral administration of a single dose to dogs

Antidepressant Use and Lifetime History of Mental Disorders in a Community Sample

Consensus clinical practice guidelines for the diagnosis and treatment of restless legs syndrome/Willis-Ekbom disease during pregnancy and lactation

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