Of social molecules: The interactive assembly of<i>ASH1</i>mRNA-transport complexes in yeast

Niedner, Annika; Edelmann, F.T.; Niessing, Dierk

doi:10.4161/rna.29946

Cited by 28 publications

(25 citation statements)

References 141 publications

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“…As was illustrated above, the interaction partners of the RBPs are ultimately responsible for the different functions that are mediated by each 3′UTR. If the interaction partner is a motor protein, the mRNA will localize to different subcellular compartments, whereas if the interaction partner is a deadenylase or a translation initiation factor, the stability or the translation rate of the mRNA may change [48, 58]. …”

Section: Discussionmentioning

confidence: 99%

Evolution and Biological Roles of Alternative 3′UTRs

Mayr

2016

Trends in Cell Biology

279

254

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More than half of human genes use alternative cleavage and polyadenylation to generate alternative 3′UTR isoforms. Most efforts have focused on transcriptome-wide mapping of alternative 3′UTRs and on the question of how 3′UTR isoform ratios may be regulated. However, it is still less clear why alternative 3′UTRs have evolved and what biological roles they play. This review summarizes our current knowledge of the functional roles of alternative 3′UTRs, including mRNA localization, mRNA stability, and translational efficiency. Recent work suggests that alternative 3′UTRs may also enable the formation of protein-protein interactions to regulate protein localization or to diversify protein functions. These recent findings open up an exciting research direction for the investigation of new biological roles of alternative 3′UTRs.

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Section: Discussionmentioning

confidence: 99%

Evolution and Biological Roles of Alternative 3′UTRs

Mayr

2016

Trends in Cell Biology

279

254

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“…Dynein 1 also transports mitotic checkpoint proteins from the kinetochore towards the poles, which helps to regulate the timing of the metaphase-anaphase transition [11, 12]. During development, dynein 1 localized at the cell cortex positions the spindle during asymmetric cell division and transports critical mRNA complexes involved in developmental patterning [13–14]. The nucleus is also positioned by dynein 1, and errors in this process cause defects in brain development [15–17].…”

Section: Overview Of the Dynein Motor Proteinmentioning

confidence: 99%

How Dynein Moves Along Microtubules

Bhabha

Johnson

Schroeder

et al. 2016

Trends in Biochemical Sciences

127

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Cytoplasmic dynein, a member of the AAA family of ATPases, drives the processive movement of numerous intracellular cargos towards the minus end of microtubules. Here, we summarize the structural and motile properties of dynein and highlight features that distinguish this motor from kinesin-1 and myosin V, two well-studied transport motors. Integrating information from recent crystal and cryo-EM structures as well as high-resolution single molecule studies, we also discuss models for how dynein biases its movement in one direction along a microtubule track, and present a movie that illustrates these principles.

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“…More often, if alternative PASs are limited to the 3′UTR, it results in transcripts with identical protein‐coding sequences, but 3′UTRs of different lengths. These APA isoforms may contain different sets of cis ‐regulatory elements in their 3′UTRs and therefore may differ in mRNA stability (Chen & Bin, ; Barreau et al , ; Bartel, ; Jonas & Izaurralde, ), translation efficiency (De Moor et al , ; Lau et al , ), intracellular localization (Ephrussi et al , ; Bertrand et al , ; An et al , ; Niednery et al , ), or even in the localization and function of the encoded proteins (Berkovits & Mayr, ). APA often shows tissue‐, cell type‐, or developmental stage‐specific patterns.…”

Section: Introductionmentioning

confidence: 99%

Pan‐tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation

Schaefke

Zou

et al. 2020

Molecular Systems Biology

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Alternative polyadenylation (APA) is a major layer of gene regulation. However, it has recently been argued that most APA represents molecular noise. To clarify their functional relevance and evolution, we quantified allele-specific APA patterns in multiple tissues from an F1 hybrid mouse. We found a clearly negative correlation between gene expression and APA diversity for the 2,866 genes (24.9%) with a dominant polyadenylation site (PAS) usage above or equal to 90%, suggesting that their other PASs represent molecular errors. Among the remaining genes with multiple PASs, 3,971 genes (34.5%) express two or more isoforms with potentially functional importance. Interestingly, the genes with potentially functional minor PASs specific to neuronal tissues often express two APA isoforms with distinct subcellular localizations. Furthermore, our analysis of cis-APA divergence shows its pattern across tissues is distinct from that of gene expression. Finally, we demonstrate that the relative usage of alternative PASs is not only affected by their cis-regulatory elements, but also by potential coupling between transcriptional and APA regulation as well as competition kinetics between alternative sites.

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Of social molecules: The interactive assembly ofASH1mRNA-transport complexes in yeast

Cited by 28 publications

References 141 publications

Evolution and Biological Roles of Alternative 3′UTRs

Evolution and Biological Roles of Alternative 3′UTRs

How Dynein Moves Along Microtubules

Pan‐tissue analysis of allelic alternative polyadenylation suggests widespread functional regulation

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