Of sight, and insight into melatonin’s role in breast cancer?

Soares-Jr, José Maria; Kesicioğlu, Tuğrul; Şengül, Demet; Şengül, İlker

doi:10.1590/1806-9282.697edit

Cited by 2 publications

(1 citation statement)

References 17 publications

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“…Long-term complications of diabetes, both microvascular and macrovascular, are a significant cause of morbidity and mortality, and glycated hemoglobin (HbA1c) plays a crucial role in developing and progressing microvascular complications like diabetic neuropathy [19][20][21][22][23][24][25] . In this study, higher HbA1c levels had longer block durations, suggesting that poor glycemic control may contribute to extended durations.…”

Section: Discussionmentioning

confidence: 99%

Do you mind the role of spinal sensory block duration in a crucial endocrine disorder of diabetes mellitus? A prospective observational study

Albayrak,

Coskun,

Sengul

et al. 2024

Rev. Assoc. Med. Bras.

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OBJECTIVE: Diabetes mellitus, per se, is a global health concern, which is often accompanied by complications such as diabetic neuropathy. This prospective observational study purposed to assess the durations of spinal sensory block and motor blocks in individuals with and without diabetes mellitus who had undergone spinal anesthesia. METHODS: This study incorporated 80 cases, which were evenly divided into spinal sensory block without diabetes mellitus and spinal sensory block with diabetes mellitus. Various parameters were recorded at different time points, including heart rate, mean arterial blood pressure, SpO 2 , and spinal block characteristics. Notable measures included maximum spinal sensory block onset time, time to reach the 10th thoracic vertebra (T10), maximal spinal sensory block, time for Bromage scores, and block regression while controlling for age-related variations. RESULTS: Patients in the diabetic group exhibited extended block durations, with significant differences in heart rate noted at specific time points. Regarding the spinal block characteristics, the "maximum onset of SSB" and the "time to reach the T10" were more prolonged in the SSBwDM without significance. Maximum sensory spinal sensory block did not differ. However, some cases in the SSBwDM displayed blocks extending up to the T6. The times to achieve Bromage motor block scores 1-3 were shorter in SSBwDM and lost significance regarding age. Notably, the regression time was longer in SSBwDM, which held significance for both parameters. CONCLUSION: Diabetic cases commonly encounter prolonged block durations post-subarachnoid intervention, potentially linked to nerve sensitivity, age-related changes, and glycemic control. As such, attenuated local doses for diabetic neuropathic cases may enhance early mobilization, attenuate thromboembolic events, and expedite gastrointestinal recovery.

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