Of Potions, Poisons, Polygonum, and Pre‐emptive Polymorphism

Aithal, Guruprasad P.

doi:10.1002/hep.30798

Cited by 4 publications

(2 citation statements)

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“…These findings provide a solid scientific basis for formulating a targeted comprehensive prevention and control strategy for liver injury risk related to PMR and its related preparations and promote the safe and rational use of TCM to a new level of precision medicine. This study is the first to identify a genetic marker for individuals susceptible to IDILI in traditional medicine, making it a successful example of translational medicine research [84] .…”

Section: Causality Evaluation and Research On The Mechanism Of Hili B...mentioning

confidence: 99%

Discovery, evaluation, prevention, and control of liver injury risk by Polygoni Multiflori Radix

Tu,

Gao,

Bai

et al. 2024

Acupuncture and Herbal Medicine

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In recent years, adverse reactions and events associated with traditional Chinese medicines (TCMs) and herbal medicines (HMs) have frequently occurred. In particular, with regard to the safety of newly discovered TCMs that have been deemed “toxic,” providing a scientifically based answer and developing effective solutions is challenging. Owing to the complexity of TCM/HM products and lack of systematic research, our understanding of the potential causes of TCM/HM-induced liver injury is limited. Therefore, significant advancements in understanding the toxicity of TCM and preventing and managing safety risks are urgently needed to address the safety concerns associated with TCMs/HMs. Using Polygoni Multiflori Radix (PMR) hepatotoxicity as a typical example, we evaluated the “integrated evidence chain” based on the causality evaluation of TCM-induced liver injury, and confirmed the objective authenticity of PMR hepatotoxicity. Furthermore, we first proposed and established a disease-syndrome-combined toxicology model that was applied to the objective evaluation and analysis of the mechanism of PMR-induced hepatotoxicity. The mechanism hypothesis of “three-factor-induced toxicity” of idiosyncratic hepatotoxicity of TCM was proposed and confirmed. Based on this, the disease characteristics of the population susceptible to PMR idiosyncratic hepatotoxicity were elucidated, and various biomarkers were screened and identified, including the genetic marker HLA-B*35:01 and immunological and metabolomic markers. Finally, the study explored and established a safe medication strategy and method for “host-drug-use” three-dimensional risk prevention and control based on identifying susceptible individuals, controlling susceptible substances, and clinical precision medication. This study provides a foundation for comprehensively understanding the scientific implications of TCM/HM toxic side reactions and establishing scientific and effective risk prevention and control strategies.

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Section: Causality Evaluation and Research On The Mechanism Of Hili B...mentioning

confidence: 99%

Discovery, evaluation, prevention, and control of liver injury risk by Polygoni Multiflori Radix

Tu,

Gao,

Bai

et al. 2024

Acupuncture and Herbal Medicine

View full text Add to dashboard Cite

show abstract

“…An association of HLA‐B*35:01 with herb‐induced liver injury has also been demonstrated in relation to Polygonum multiflorum among Han Chinese and green tea in White people, highlighting the shared mechanisms underlying DILI attributed to different causative agents. ( 8 ) Beyond genetics, other factors inextricably linked to ethnicity such as health literacy, immigration, and acculturation that potentially affect HDS use and hence their adverse effects have not been evaluated. Finally, the size of the population exposed would be a key determinant of the HDS‐induced liver injury.…”

mentioning

confidence: 99%