Of Mice and Men

Traverse, Jay H.

doi:10.1161/circresaha.113.301079

Cited by 12 publications

(7 citation statements)

References 16 publications

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“…2 Furthermore, Fournier et al supposed methodological issues in our study that could have led to failure to investigate the time-ofday effect adequately on myocardial infarct size. On the contrary, Traverse 7 did not detect any of the presumed methodological issues. We performed ≈20 analyses (pertaining to a combination of different clinical inclusion criteria, different ethnical and hospital origins, and different statistical methodologies), and only in one of them, considering an Italian multicentric cohort, the Kruskal-Wallis test showed a difference in the CK peak level in the first quarter of the day (midnight to 6:00 am).…”

contrasting

confidence: 60%

Still Need for Compelling Evidence to Support the Circadian Dependence of Infarct Size After ST-Elevation Myocardial Infarction

Ammirati

Maseri²,

Cannistraci

2013

Circulation Research

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contrasting

confidence: 60%

Still Need for Compelling Evidence to Support the Circadian Dependence of Infarct Size After ST-Elevation Myocardial Infarction

Ammirati

Maseri²,

Cannistraci

2013

Circulation Research

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“…The circadian clocks are molecular mechanisms residing within individual cells that directly modulate cellular function during the course of the day to optimize their physiology with their environment 14 and participate in TOD-dependent changes of several cardiovascular physiological processes (heart rate, blood pressure, and platelet activation). 15,16 Myocardial ischemia-reperfusion injury is the consequence of reoxygenation of ischemic cardiac tissue and reenergization of mitochondria that exacerbates cardiac cell damage through the generation of oxygen free radicals and loss of cardiomyocytes via activation of apoptosis. 17 Thus, infarct size is the consequence of ischemia injury plus ischemia-reperfusion injury.…”

Section: Discussionmentioning

confidence: 99%

Time-of-Day and Clinical Outcomes After Surgical or Transcatheter Aortic Valve Replacement: Insights From the PARTNER Trials

Vincent

Thourani

Ternacle

et al. 2022

Circ: Cardiovascular Quality and Outcomes

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Background: Circadian rhythms may influence myocardial tolerance to ischemia-reperfusion phenomena occurring during cardiac procedures. While conflicting results exist on the effect of time-of-day on surgical aortic valve replacement (SAVR), afternoon procedures could be associated with a reduced risk of death, rehospitalization or periprocedural myocardial infarction, compared with morning procedures. We examined the impact of procedure time-of-day on outcomes after transcatheter aortic valve replacement (TAVR) or SAVR. Methods: We analyzed patients at intermediate- or high-surgical risk who underwent elective TAVR (n=4457) or SAVR (n=1129) in the PARTNER (Placement of Aortic Transcatheter Valve) 1 and 2 trials and registries according to time-of-day (morning versus afternoon) using the Kaplan-Meier event rates and multivariable Cox proportional hazards regression models. Sensitivity analysis was conducted using 1:1 propensity-score matching. The primary end point was all-cause death or rehospitalization at 2 years. Results: At 2 years, no difference was observed between patients operated in the morning versus the afternoon within the SAVR (32.3% versus 30.6%, adjusted hazard ratio, 1.08 [95% CI, 0.82–1.41], P =0.58) and TAVR cohorts (35.7% versus 35.4%, adjusted hazard ratio, 1.01 [95% CI, 0.89–1.14], P =0.86) with regards to the primary end point. Rates of periprocedural myocardial infarction were low and similar between morning and afternoon in SAVR (1.6% versus 1.0%, P =0.51) and TAVR (0.4% versus 0.4%, P =0.86), as were all other clinical end points. Similar results were observed in propensity-score matched analysis. Conclusions: Procedure time-of-day was not associated with clinical outcomes after TAVR or SAVR. Registration: URL: https://www.clinicaltrials.gov ; Unique identifiers: NCT00530894, NCT01314313, NCT03222141, and NCT03222128.

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“…Time of day affects the incidence of various acute pathologies including myocardial infarct (MI) and ischemic stroke [1]. Moreover, the severity of those injuries may also be influenced by the time of day at which they occur [2, 3]. Such effects stem from circadian rhythmicity of biological processes that determine risk of a blood vessel occlusion and/or rupture and/or modify the tissue injury response [1].…”

Section: Introductionmentioning

confidence: 99%

Unaffected functional recovery after spinal cord contusions at different circadian times

Słomnicki

Wei

Burke

et al. 2021

Preprint

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The circadian rhythms of gene expression drive diurnal oscillations of physiological processes that determine the acute injury response including immunity, inflammation and hemostasis. While outcomes of various acute injuries are affected by the time of day at which the original insult occurred, such diurnal influences on recovery after spinal cord injury (SCI) are unknown. We report that several key regulators of circadian gene expression are differentially expressed in uninjured spinal cord tissue of naïve mice at Zeitgeber time 1 (ZT1) or ZT12, where ZT0 or ZT12 are times when lights are turned on or off, respectively. However, mice that received moderate, T9 contusive SCI at ZT0 or ZT12 showed similar recovery of locomotion as determined using the ladder walking test and the Basso mouse scale (BMS) over a 6 week post-injury period. Consistent with those findings, terminal histological analysis revealed no significant differences in white matter sparing at the injury epicenter. Therefore, locomotor recovery after thoracic contusive SCI is not affected by the time of day at which the neurotrauma occurred at least when comparing the beginning to the end of the mouse active period.

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Of Mice and Men

Cited by 12 publications

References 16 publications

Still Need for Compelling Evidence to Support the Circadian Dependence of Infarct Size After ST-Elevation Myocardial Infarction

Still Need for Compelling Evidence to Support the Circadian Dependence of Infarct Size After ST-Elevation Myocardial Infarction

Time-of-Day and Clinical Outcomes After Surgical or Transcatheter Aortic Valve Replacement: Insights From the PARTNER Trials

Unaffected functional recovery after spinal cord contusions at different circadian times

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