Of mice and men (and women): Comment on Peacock et al., 2018

Ruff, Christopher B.; Warden, Stuart J.; Carlson, Kristian J.

doi:10.1002/ajpa.23615

Cited by 4 publications

(3 citation statements)

References 19 publications

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“…possibly the strain 3 wheel access interaction. Results of our reanalysis are summarized in Tables 2 and 3, which are comparable to Ruff et al's (2018) Figure 2a and 2c which is unsurprising, given previously observed shape differences in MM mice relative to unaffected mice (Middleton et al, 2010).…”

Section: Ruff Et Al Reanalyze Our Data For Estimates Of Bending Rigisupporting

confidence: 75%

“…Although we were not able to exactly reproduce the p values in Ruff et al's (2018) Figure 1, even using a factorial ANCOVA on our own data, we agree that log-transformed femoral length predicted by log-transformed body mass are credibly different between strains. The posterior intervals of differences between MM and C57 or C3H have about 99% posterior probability of not including zero, with no credible effect of wheel access (Table 1).…”

mentioning

confidence: 52%

“…and I ml ; in Ruff et al 2018 Figure 2). They first convert the relevant data to ratios: ln(I ap /mass) and ln(I ap /mass).…”

Section: Ruff Et Al Reanalyze Our Data For Estimates Of Bending Rigimentioning

confidence: 91%

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Reply to Ruff, Warden, and Karlson

Peacock

Garland

Middleton

2018

American J Phys Anthropol

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We welcome Ruff, Warden, and Karlson's letter in response to our recent (Peacock et al., 2018) analysis of the relative differences in skeletal traits among and within three strains of mice. Our goal was to highlight the challenges of interpreting skeletal phenotypes as primarily the result of habitual physical activity. We found higher prevalence of Our reanalysis of our data here used both frequentist linear models for closest approximation to Ruff et al.'s analysis (i.e., R function lm) and Bayesian linear models estimated using the stan sampler (Carpenter, et al. 2017), the rstanarm package (https://cran.r-project.org/package5rstanarm) for Am J Phys Anthropol. 2018;1-4. wileyonlinelibrary.com/journal/ajpa V C 2018 Wiley Periodicals, Inc. | 1

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Section: Ruff Et Al Reanalyze Our Data For Estimates Of Bending Rigisupporting

confidence: 75%

mentioning

confidence: 52%

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Reply to Ruff, Warden, and Karlson

Peacock

Garland

Middleton

2018

American J Phys Anthropol

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Intrapopulation variation in lower limb trabecular architecture

Mulder

Stock

Saers

et al. 2020

American J Phys Anthropol

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ObjectivesTrabecular structure is frequently used to differentiate between highly divergent mechanical environments. Less is known regarding the response of the structural properties to more subtle behavioral differences, as the range of intrapopulation variation in trabecular architecture is rarely studied. Examining the extent to which lower limb trabecular architecture varies when inferred mobility levels and environment are consistent between groups within a relatively homogenous population may aid in the contextualization of interpopulation differences, improve detectability of sexual dimorphism in trabecular structure, and improve our understanding of trabecular bone functional adaptation.Materials and methodsThe study sample was composed of adult individuals from three high/late medieval cemeteries from Cambridge (10th–16th c.), a hospital (n = 57), a parish cemetery (n = 44) and a friary (n = 14). Trabecular architecture was quantified in the epiphyses of the femur and tibia, using high resolution computed tomography.ResultsThe parish individuals had the lowest bone volume fraction and trabecular thickness in most regions. Multiple sex differences were observed, but the patterns were not consistent across volumes of interest.DiscussionDifferences between the three groups highlight the great variability of trabecular bone architecture, even within a single sedentary population. This indicates that trabecular bone may be used in interpreting subtle behavioral differences, and suggests that multiple archaeological sites need to be studied to characterize structural variation on a population level. Variation in sex and group differences across anatomical locations further demonstrates the site‐specificity in trabecular bone functional adaptation, which might explain why little consistent sexual dimorphism has been reported previously.

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